Protein Alignment S6kII and rps6kal

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_956367.1
• Gene: rps6kal / 337670
• ZFINID: ZDB-GENE-030131-9616
• Length: 740
• Species: Danio rerio
• Alignment Length: 745
• Identity: 428/745 - (57%)
• Similarity: 532/745 - (71%)
• Gaps: 60/745 - (8%)

  Fly   172 EPLYETE----NEFELKEV-----IKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTL 227
            ||:.|..    :|...||:     :|||.:||||||||||:|||:|||||||||||::|.|||.|
Zfish    31 EPMEEESYTHCDEGAYKEIPITHHVKEGCEKADPSQFELLKVLGQGSFGKVFLVRKLMGPDAGQL 95

  Fly   228 YAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSK 292
            |||||||||:|||:||||:..||.||.:|.|.|||:|||||||.||||||||||||||:||||||
Zfish    96 YAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSK 160

  Fly   293 EVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKTY 356
            |||||||||||||||||||::|||.|||:|||||||||||||.|||.||||||||:.:| ..|.|
Zfish   161 EVMFTEEDVKFYLAELALALDHLHNLGIVYRDLKPENILLDEAGHIKLTDFGLSKESVDQDKKAY 225

  Fly   357 SFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENL 421
            ||||||||||||:|||:||..:|||||.||||:|||||.|||.|:.|.||||.||::|||||:.|
Zfish   226 SFCGTVEYMAPEVVNRRGHTQSADWWSLGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFL 290

  Fly   422 SPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFY 485
            |.|||.|||.||||||.||||||..|:.:||.|.||:||||.:|.|::::|||.||..: ||.|.
Zfish   291 SLEAQGLLRMLFKRNPSNRLGAGPDGVEEIKRHTFFSTIDWNKLYRRELQPPFKPASGKPDDTFC 355

  Fly   486 FDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPV 550
            ||.|:|:|:|:||||.|.||:||::|:||||||||.||         .:.::||.:|.||.....
Zfish   356 FDPEFTAKTPKDSPGIPPSANAHQLFKGFSFVAPVSLE---------ESKSAPLVNILPIVQVHG 411

  Fly   551 GAPRTLPGVLPGNFHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADC 615
            .:         ..|...|.|.:::|.|::|:|:.|.||.:...:|||:|:|         :..|.
Zfish   412 SS---------AQFSDVYELKEDIGVGSYSICKRCIHRVTAMEFAVKIIDK---------SKRDP 458

  Fly   616 WEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIAS 680
            .||:||::|||.||||:||..||::....|||.||:|||||||:||......|.||||||.||..
Zfish   459 SEEIEILMRYGQHPNIITLKDVYDEGRFVYLVTELMKGGELLDKILRQKFFSEREASAVLYTITK 523

  Fly   681 AVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVL 745
            .|.|||..|||||||||||::|......|:::::||.|||||||.|||||:||||||||||||||
Zfish   524 TVDYLHCQGVVHRDLKPSNILYMDDSGNPDSIRICDFGFAKQLRGDNGLLLTPCYTANFVAPEVL 588

  Fly   746 KRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKEL 810
            .|||||.||||||||||||.||:|.||||:.|||:|:.||.|||||:...:...|..:|..:|:|
Zfish   589 MRQGYDAACDIWSLGVLLYTMLAGYTPFANGPNDTPEEILLRIGSGKFSLSGGNWDSVSDSSKDL 653

  Fly   811 LRQMLHIVPENRPTAARILEHDWL--REQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALRG 873
            |..|||:.|.:|.||.::|:|.|:  |:|            .|..||:    :.:..|:   ::|
Zfish   654 LSHMLHVDPHHRYTAEQVLKHSWIACRDQ------------NPHFQLT----RHEAPHL---VKG 699

  Fly   874 AVDATFRAIAIPQAANV-GPVELSMLAKRR 902
            |:.||:.|:.......| .||..|.||:||
Zfish   700 AMAATYSALNHKTCKPVLEPVAASSLAQRR 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	229/315 (73%)
		STKc_RSK_C	567..883	CDD:270993	159/317 (50%)
rps6kal	NP_956367.1	STKc_RSK_N	71..387	CDD:270734	229/315 (73%)
		STKc_RSK4_C	415..709	CDD:271079	160/321 (50%)