Protein Alignment S6kII and Rps6ka6

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_001178650.1
• Gene: Rps6ka6 / 317203
• RGDID: 1560817
• Length: 860
• Species: Rattus norvegicus
• Alignment Length: 919
• Identity: 448/919 - (48%)
• Similarity: 567/919 - (61%)
• Gaps: 139/919 - (15%)

  Fly     2 PLADSQKDLRQ--------QPQQQQQQQHVSSTSSSNNAEQQCSSSGLGLQLRQRMQITSSGCSS 58
            |||.|....|:        :|.||.....|..|||..::..:                    .:.
  Rat    53 PLARSAVTQRESWSYEEDHEPAQQAGCMLVLGTSSFFSSVPE--------------------AAM 97

  Fly    59 LAVTPMEHTPTEDDESGGGNSGVTSSVTTVTSSQRRQQLQQVQQQSALQAALEQHHISPTADLDS 123
            |...|:|....|:.|..|  ||.|||          .:.|.|.........:.||......||
  Rat    98 LPFAPVEDPWDEEMEVFG--SGSTSS----------SEPQIVFTMKTAAMVIRQHEHKEVNDL-- 148

  Fly   124 ARKRPTHRTLCPPPELMELSDSESQGGVETGGRREGATGRSAPDLEDTEPLYETENEFELKEVIK 188
                             ::.|.....|.....|||                 :...|..:.:.:|
  Rat   149 -----------------KMVDEPMDEGEPVFCRRE-----------------DLVKEIPITQHVK 179

  Fly   189 EGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKIL 253
            ||::||||:||:||:|||:|||||||||||..|.|||.|||||||:||:|||:||||:..||.||
  Rat   180 EGYEKADPAQFDLLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLRKASLKVRDRVRTKMERDIL 244

  Fly   254 ADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTL 318
            .:|.|.|||:|||||||.||||||||||||||:||||||||:||||||||||||||||::|||.|
  Rat   245 VEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHRL 309

  Fly   319 GIIYRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYSFCGTVEYMAPEIVNRKGHDFAADWW 382
            ||:|||||||||||||.|||.||||||||:.:| ..|.|||||||||||||:|||:||..:||||
  Rat   310 GIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWW 374

  Fly   383 SFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQG 447
            |:||||:|||||.|||.|:.|.||||.||::|||||:.||.|||||||.||||||.|||  |::|
  Rat   375 SYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRL--GSEG 437

  Fly   448 ILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFYFDVEYTSKSPRDSPGGPISASAHEIF 511
            :.::|.|.||::|||.:|.:::|:|||.||..: ||.|.||.|:|:|:|:||||.|.||:||::|
  Rat   438 VEEVKRHAFFSSIDWNKLYKREVQPPFRPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLF 502

  Fly   512 RGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPGV-LPGN---FHAEYNLLQ 572
            :||||||               ||.:..:.|.|:.::.|     ||.| :.||   |...|.|.:
  Rat   503 KGFSFVA---------------TSIAEEYKITPVTSSNV-----LPIVQINGNAAQFSEAYELKE 547

  Fly   573 ELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSV 637
            ::|.|::|||:.|.|.||...:|||:|:|         ...|..||:||::|||.||||::|..|
  Rat   548 DIGIGSYSVCKRCIHSASNMEFAVKIIDK---------NKRDPSEEIEILMRYGQHPNIISLKEV 603

  Fly   638 YEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIY 702
            ::|....|||.:|:||||||||||......|.|||.||..|...|.|||..|||||||||||::|
  Rat   604 FDDGKYVYLVTDLMKGGELLDRILKKKCFSEQEASNVLYVITKTVEYLHSQGVVHRDLKPSNILY 668

  Fly   703 ASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIML 767
            ......|:::|:||.|||||||.:||||:||||||||||||||.:||||.||||||||||||.||
  Rat   669 MDESGHPDSIKICDFGFAKQLRGENGLLLTPCYTANFVAPEVLTQQGYDAACDIWSLGVLLYTML 733

  Fly   768 SGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHD 832
            :|.|||::.|||:|:.||.|||:|:...:...|..||..||:||..|||:.|..|.||.::|:|.
  Rat   734 AGYTPFSNGPNDTPEEILLRIGNGRFSLSGGIWDNISRGAKDLLSHMLHMDPHQRYTAEQVLKHP 798

  Fly   833 WL--REQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALRGAVDATFRAIAIPQAAN--VGPV 893
            |:  |||.            |..|.:.....|:          ||.|.:..:|..|..:  :.||
  Rat   799 WITQREQL------------PRHQPTSDDPPQE----------AVAAAYSVLARNQNRHPILEPV 841

  Fly   894 ELSMLAKRR 902
            ..|.||:||
  Rat   842 AASRLAQRR 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	224/315 (71%)
		STKc_RSK_C	567..883	CDD:270993	155/317 (49%)
Rps6ka6	NP_001178650.1	STKc_RSK_N	194..508	CDD:270734	224/315 (71%)
		STKc_RSK_C	543..829	CDD:270993	155/316 (49%)