Protein Alignment S6kII and Rps6ka5

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_001382521.1
• Gene: Rps6ka5 / 314384
• RGDID: 1308336
• Length: 798
• Species: Rattus norvegicus
• Alignment Length: 804
• Identity: 322/804 - (40%)
• Similarity: 448/804 - (55%)
• Gaps: 97/804 - (12%)

  Fly   146 ESQGGVETGGRREGATGRSAPDLEDTEPLYETENEFELKEVIKEGH-DKADPSQFELLRVLGEGS 209
            |.:||...|....|.:|      :..|.|...::  ||:.....|| :|.....||||:|||.|:
  Rat     2 EGEGGGSGGAGTSGDSG------DGGEQLLTVKH--ELRTANLTGHAEKVGIENFELLKVLGTGA 58

  Fly   210 FGKVFLVRKIIGKDAGTLYAMKVLKKATL--KVKDRVRSTNERKILADVGHA-FIVRLHYAFQTP 271
            :|||||||||.|.|||.|||||||||||:  |.|....:..||::|..:..: |:|.|||||||.
  Rat    59 YGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTE 123

  Fly   272 GKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHG 336
            .||:||||::.||:|||.||:...|||.:|:.|:.|:.||:.|||.|||||||:|.||||||.:|
  Rat   124 TKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNG 188

  Fly   337 HIALTDFGLSKQPL--DGSKTYSFCGTVEYMAPEIV--NRKGHDFAADWWSFGVLMYEMLTGNLP 397
            |:.||||||||:.:  :..:.||||||:|||||:||  ...|||.|.||||.||||||:|||..|
  Rat   189 HVVLTDFGLSKEFVADEAERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASP 253

  Fly   398 F----HGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFA 458
            |    ...::.|...:||:|:...|:.:|..|:.||:.|..::|:.|||.|.:...:||.|.||.
  Rat   254 FTVDGEKNSQAEISRRILKSEPPYPQGMSSVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFFE 318

  Fly   459 TIDWVRLERKQVRPPFIPAVSRD--DAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVL 521
            .|:|..|..|:|..||.|.: ||  |...|..|:|...|..||.. :..|:..:|:|:|||||.:
  Rat   319 KINWDDLAAKKVPAPFKPVI-RDELDVSNFAEEFTEMDPTYSPAA-LPQSSERLFQGYSFVAPSI 381

  Fly   522 LEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPGVL---------PGNFHAEYNL-LQE--L 574
            |..:    |.........|         :|..|  |||.         ...|:..|:| |::  |
  Rat   382 LFKR----NAAVIDPLQFH---------MGVDR--PGVTNVARSAMMKDSPFYQHYDLDLKDKPL 431

  Fly   575 GRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYE 639
            |.|:||:||.|.|:.:.:.:|||:|.|        ...|:..:|:..:.....|||:|.|:.|:.
  Rat   432 GEGSFSICRKCVHKKTNQAFAVKIISK--------RMEANTQKEITALKLCEGHPNVVKLHEVFH 488

  Fly   640 DAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYAS 704
            |....:||||||.||||.:||.......|:|||.::|.:.|||:::|:.|||||||||.|:::..
  Rat   489 DQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTD 553

  Fly   705 MRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSG 769
            .....| :|:.|.|||:....||..|.|||:|.::.|||:|...|||.:||:|||||:||.||||
  Rat   554 ENDNLE-IKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLTHNGYDESCDLWSLGVILYTMLSG 617

  Fly   770 RTPFASTPND----SPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILE 830
            :.||.|....    |...|:|:|..|...|....|..:|..||:|::.:|.:.|..|...:.:..
  Rat   618 QVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRY 682

  Fly   831 HDWLREQFAGGVQLTEYAVAPGSQLS---------LGAQQQQQNHISMALRGAVDATFRAIAIPQ 886
            ::||::               |||||         ||:.       ..|:...|.|||.|....:
  Rat   683 NEWLQD---------------GSQLSSNPLMTPDILGSS-------GAAVHTCVKATFHAFNKYK 725

  Fly   887 AAN--VGPVELSMLAKRRAKDRAN 908
            ...  :..|:.:.|||||...|.:
  Rat   726 REGFCLQNVDKAPLAKRRKMKRTS 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	163/326 (50%)
		STKc_RSK_C	567..883	CDD:270993	122/331 (37%)
Rps6ka5	NP_001382521.1	Protein Kinases, catalytic domain	47..379	CDD:473864	169/333 (51%)
		STKc_MSK1_C	417..726	CDD:271081	123/339 (36%)