DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and SNX15

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_037438.2	Gene:	SNX15 / 29907	HGNCID:	14978	Length:	342	Species:	Homo sapiens

Alignment Length:	218	Identity:	44/218 - (20%)
Similarity:	69/218 - (31%)	Gaps:	74/218 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 GTVEY-MAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSP 423
            |..|| :..:.:::|..:...:     |::::..:.....||.... |...:.|.....|  ..|
Human    24 GYTEYKVTAQFISKKDPEDVKE-----VVVWKRYSDFRKLHGDLAY-THRNLFRRLEEFP--AFP 80

  Fly   424 EAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSRDDAFYFDV 488
            .||...|  |:.:.......||:.:|....|                    |||::.
Human    81 RAQVFGR--FEASVIEERRKGAEDLLRFTVH--------------------IPALNN-------- 115

  Fly   489 EYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAP--IPAAPVG 551
                           |....|.|||.....|:.:             :..||.:.|  ||..|..
Human   116 ---------------SPQLKEFFRGGEVTRPLEV-------------SRDLHILPPPLIPTPPPD 152

  Fly   552 APRTLPGVLPGNFHAEYNLLQEL 574
            .|| |..:||    ||...|:||
Human   153 DPR-LSQLLP----AERRGLEEL 170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	19/97 (20%)
		STKc_RSK_N	203..517	CDD:270734	27/157 (17%)
		STKc_RSK_C	567..883	CDD:270993	4/8 (50%)
		S_TKc	568..834	CDD:214567	3/7 (43%)
SNX15	NP_037438.2	PX_domain	9..126	CDD:321991	26/154 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..267
		MIT_SNX15	267..341	CDD:239140
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900