DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6kII and Sgk2

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_038759.1	Gene:	Sgk2 / 27219	MGIID:	1351318	Length:	367	Species:	Mus musculus

Alignment Length:	332	Identity:	148/332 - (44%)
Similarity:	206/332 - (62%)	Gaps:	13/332 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 ADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVL-KKATLKVKDRVRSTNERKI-LADV 256
            |.|:.|:.|:|:|:|::|||.|.::   |..|..||:||| ||:.||.|::.....||.: |.:|
Mouse    30 ARPTDFDFLKVIGKGNYGKVLLAKR---KSDGAFYAVKVLQKKSILKNKEQNHIMAERNVLLKNV 91

  Fly   257 GHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGII 321
            .|.|:|.|.|:||||.|||.:||::.||:||..|.:|..|.|...:||.||:|.|:.:||:|.||
Mouse    92 RHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYTAEVASAIGYLHSLNII 156

  Fly   322 YRDLKPENILLDEHGHIALTDFGLSKQPLDGSKTYS-FCGTVEYMAPEIVNRKGHDFAADWWSFG 385
            ||||||||||||..||:.||||||.|:.::..:|.| ||||.||:|||::.::.:|.|.|||..|
Mouse   157 YRDLKPENILLDCQGHVVLTDFGLCKECVEPEETTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLG 221

  Fly   386 VLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILD 450
            .::||||.|..||......:....||...|.:|...:..|..||:.|..::.:.|||: .:..||
Mouse   222 AVLYEMLHGLPPFFNTDVAQMYENILHQPLQIPGGRTVAACDLLQGLLHKDQRQRLGS-KEDFLD 285

  Fly   451 IKAHCFFATIDWVRLERKQVRPPFIPAVSRD-DAFYFDVEYT----SKSPRDSPGGPISAS-AHE 509
            ||.|.||:.|:|..|..|::.|||.|.|... |..:||.|:|    |||...:|....|:| |..
Mouse   286 IKNHMFFSPINWDDLYHKRLTPPFNPNVEGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASS 350

  Fly   510 IFRGFSF 516
            .|.|||:
Mouse   351 AFLGFSY 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	119/260 (46%)
		STKc_RSK_N	203..517	CDD:270734	144/323 (45%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
Sgk2	NP_038759.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		PKc_like	39..359	CDD:389743	144/323 (45%)
		Nuclear localization signal. /evidence=ECO:0000250	68..78		5/9 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.030