Protein Alignment S6kII and Sgk2

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_038759.1
• Gene: Sgk2 / 27219
• MGIID: 1351318
• Length: 367
• Species: Mus musculus
• Alignment Length: 332
• Identity: 148/332 - (44%)
• Similarity: 206/332 - (62%)
• Gaps: 13/332 - (3%)

  Fly   194 ADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVL-KKATLKVKDRVRSTNERKI-LADV 256
            |.|:.|:.|:|:|:|::|||.|.::   |..|..||:||| ||:.||.|::.....||.: |.:|
Mouse    30 ARPTDFDFLKVIGKGNYGKVLLAKR---KSDGAFYAVKVLQKKSILKNKEQNHIMAERNVLLKNV 91

  Fly   257 GHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGII 321
            .|.|:|.|.|:||||.|||.:||::.||:||..|.:|..|.|...:||.||:|.|:.:||:|.||
Mouse    92 RHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYTAEVASAIGYLHSLNII 156

  Fly   322 YRDLKPENILLDEHGHIALTDFGLSKQPLDGSKTYS-FCGTVEYMAPEIVNRKGHDFAADWWSFG 385
            ||||||||||||..||:.||||||.|:.::..:|.| ||||.||:|||::.::.:|.|.|||..|
Mouse   157 YRDLKPENILLDCQGHVVLTDFGLCKECVEPEETTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLG 221

  Fly   386 VLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILD 450
            .::||||.|..||......:....||...|.:|...:..|..||:.|..::.:.|||: .:..||
Mouse   222 AVLYEMLHGLPPFFNTDVAQMYENILHQPLQIPGGRTVAACDLLQGLLHKDQRQRLGS-KEDFLD 285

  Fly   451 IKAHCFFATIDWVRLERKQVRPPFIPAVSRD-DAFYFDVEYT----SKSPRDSPGGPISAS-AHE 509
            ||.|.||:.|:|..|..|::.|||.|.|... |..:||.|:|    |||...:|....|:| |..
Mouse   286 IKNHMFFSPINWDDLYHKRLTPPFNPNVEGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASS 350

  Fly   510 IFRGFSF 516
            .|.|||:
Mouse   351 AFLGFSY 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	144/323 (45%)
		STKc_RSK_C	567..883	CDD:270993
Sgk2	NP_038759.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		Protein Kinases, catalytic domain	39..359	CDD:473864	144/323 (45%)
		Nuclear localization signal. /evidence=ECO:0000250	68..78		5/9 (56%)