Protein Alignment S6kII and Stk36

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_778196.2
• Gene: Stk36 / 269209
• MGIID: 1920831
• Length: 1316
• Species: Mus musculus
• Alignment Length: 764
• Identity: 174/764 - (22%)
• Similarity: 307/764 - (40%)
• Gaps: 166/764 - (21%)

  Fly   198 QFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIV 262
            ::.:|.::||||||:|:..||   |.:..:.|:|.:.|.....|:......|.:|:..:.|..||
Mouse     3 KYHVLEMIGEGSFGRVYKGRK---KYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLWHPNIV 64

  Fly   263 RLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKP 327
            .:..:|:|..::.::.|:.. |:||..|..:....|:.|:...|:|..|:.:||:..|::||:||
Mouse    65 HMLDSFETDKEVVVVTDYAE-GELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKP 128

  Fly   328 ENILLDEHGHIALTDFGLSKQPLDGSKTY-SFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEM 391
            :||||.:.|.|.|.|||.::.....:... |..||..||:||:|..:.:|..||.||.|.::||:
Mouse   129 QNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYEL 193

  Fly   392 LTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCF 456
            ..|..||:..:..:.::.||:..:..|..:|...::.|:.|..::|:.||...     |:..|.|
Mouse   194 AVGTPPFYTTSIFQLVSLILKDPVRWPSTISSCFKNFLQGLLTKDPRQRLSWP-----DLLHHPF 253

  Fly   457 FATIDWVRLERKQVRPPFIPAVSRDDAFYFDVEYTSKSP------------RDSPGGPISASAHE 509
            .|.           |...|...:..|   ....:||:.|            |.:|.|..|....:
Mouse   254 IAG-----------RVTIITEPAGSD---LGTPFTSRLPPELQVLKDEQAHRLAPKGNQSRILRQ 304

  Fly   510 IFRGFSFVAPVLLEGQCAGS------NMCSTSASPLHSIAPIP---AAPVGAPRTLPGVLPGNFH 565
            ..:..:..|. ..|.|.|||      .:|..:.    |.||:|   |.|..: ..|.|:|.....
Mouse   305 ACKLMAEEAK-QKEDQNAGSALEQEDGLCKVTP----STAPVPGLKATPQES-SLLAGILASEMK 363

  Fly   566 AEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKA-------AVAAASTST---------SAD 614
               |..::.|.|.       ..|.|::::.....|:.       |:...||..         |.|
Mouse   364 ---NNWEDWGAGE-------APRTSRENHINLECEQGFPEPRPEAMGRQSTDVVDPENEEPDSDD 418

  Fly   615 CWEEVEIMLRYGNHPNIVTL----------------YSVYEDAGSAYLVMELLKGGELLDRILAV 663
            .|:.    |...:.|..|.|                .|.....|.     ::|||  :||.:
Mouse   419 EWQR----LLETSEPGPVQLKSPLTLLCNPDFCQRIQSQLRGTGE-----QILKG--VLDGV--- 469

  Fly   664 GQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQT--PETLKLCDLGFAKQLRAD 726
                 |....|||.::|.::..::          |.::|:..::.  || |.|..|.::::   .
Mouse   470 -----SHLLPVLRILSSLLSSCND----------SVLLYSFCQEAGLPE-LPLSLLRYSQE---S 515

  Fly   727 NGLLMTPCY-----------TANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDS 780
            :.:...|.|           .|.|.....|:|.....:..::.....|::.|.|:  ..:..:||
Mouse   516 SSIQQQPWYGALLRDLVAVVQAYFSCTFNLERSQTGDSLQVFQEAASLFLDLLGK--LLAQSDDS 578

  Fly   781 PD-----------VILKRIGSGQIDFTSSRWALISVPAKELLRQMLH--IVPE----NRPTAARI 828
            ..           |:.:.:.......:.:.::.:....:.:|..:||  .||:    ..|.|.::
Mouse   579 EQTFRRDSLMCFAVLCEAVDGNSWAVSKAFYSSLLTTQRAVLDGLLHGLTVPQLPFHTPPGAPQV 643

  Fly   829 LEHDWLREQ---FAGGVQ--LTEYAVAP-GSQLSLGAQQQQQNHISMAL 871
            .:.  ||||   ..|.:.  |.....|| |......|::|...|::..|
Mouse   644 SQP--LREQSEDVPGAISSALAAMCTAPVGLPSCWDAKEQVSWHLANQL 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	90/326 (28%)
		STKc_RSK_C	567..883	CDD:270993	67/373 (18%)
Stk36	NP_778196.2	STKc_STK36	2..254	CDD:270904	79/259 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..418		4/28 (14%)