DRSC/TRiP Functional Genomics Resources

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Protein Alignment S6kII and RPS6KC1

DIOPT Version :9

Sequence 1:NP_001259779.1 Gene:S6kII / 33139 FlyBaseID:FBgn0262866 Length:911 Species:Drosophila melanogaster
Sequence 2:NP_036556.2 Gene:RPS6KC1 / 26750 HGNCID:10439 Length:1066 Species:Homo sapiens


Alignment Length:640 Identity:136/640 - (21%)
Similarity:224/640 - (35%) Gaps:209/640 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 QQHVSSTSSSNNAEQQCSSSG---LGLQLRQRMQITSSGCSSLAVTPMEHTPTEDDESGGGNSGV 81
            ||..||...|::.|.:.|..|   ..|.|:..:..:|...|:......:.:|...|.........
Human   444 QQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEEC 508

  Fly    82 TSSVTTVTSSQRRQQLQ--QVQQQSALQA--------ALEQH--HISPTADLDSARKRPTHRTLC 134
            |:|..|:.:...:::::  .:.::..::.        |::..  |::..:|..|.:.|.......
Human   509 TTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGNGVDTKAIKSFPAHLAADSDSPSTQLRAHELKFF 573

  Fly   135 P----------------------PPELMELSDSESQG---GVETGGRREGATGR------SAPDL 168
            |                      |.|...:...:|..   |::.|.:.......      :.||.
Human   574 PNDDPEAVSSPRTSDSLSRSKNSPMEFFRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDG 638

  Fly   169 EDTEPLYETEN---EFELKEVIKEGHDKADP------SQFE------------LLRVLGE----- 207
            :.....:.|..   ||:.::.|..|.|.:.|      :.|:            |:.:.||     
Human   639 DSASRSFNTSESKVEFKAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTR 703

  Fly   208 --GSFGKVFLVRKIIGKDAGTLYAMKVLKK---ATLKVKDRVRSTNERKILADVGHA------FI 261
              .:.|.....:..||     :...|:|:.   ..|::.......:|.|.:.::...      .|
Human   704 EAAAMGPTKFTQTNIG-----IIENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSI 763

  Fly   262 VRLHYAFQTPGKLYL-ILDFLRGGD---------------------------------------- 285
            ...|||.:.|..|:: .:|....||                                        
Human   764 TEKHYAQEDPRMLFVAAVDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGA 828

  Fly   286 --------------------------------LFTRLS-------------KEVMFTEEDV---- 301
                                            ||.|.|             ||:....||:    
Human   829 NEYIASTDTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKL 893

  Fly   302 ----KFYL---------AELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLDGS 353
                :||:         ||:.:|::.||..||:.|||.|.||||::.|||.||.|....:..|..
Human   894 ALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSC 958

  Fly   354 KTYSFCGTVE--YMAPEIVNRKGHDFAADWWSFGVLMYEMLTGN--LPFH--GQTRQETMNQILR 412
            .:    ..:|  |.|||:........|.||||.|.:::|:|||.  :..|  |.....|:|    
Human   959 DS----DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLN---- 1015

  Fly   413 SKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLER 467
                |||.:|.||:||::.|.:.||..|||||..|:.|||:|.||..:||..|.|
Human  1016 ----MPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
S6kIINP_001259779.1 S_TKc 199..457 CDD:214567 93/394 (24%)
STKc_RSK_N 203..517 CDD:270734 97/390 (25%)
STKc_RSK_C 567..883 CDD:270993
S_TKc 568..834 CDD:214567
RPS6KC1NP_036556.2 PX_RPK118_like 11..128 CDD:132820
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..228
MIT_SNX15 238..312 CDD:239140
PKc_like 335..>421 CDD:304357
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 441..509 14/64 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 553..596 5/42 (12%)
S_TKc <875..1056 CDD:214567 68/192 (35%)
STKc_RPK118_like <879..1056 CDD:270728 68/188 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0603
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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