DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and gad8

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_588010.1	Gene:	gad8 / 2539206	PomBaseID:	SPCC24B10.07	Length:	569	Species:	Schizosaccharomyces pombe

Alignment Length:	560	Identity:	190/560 - (33%)
Similarity:	286/560 - (51%)	Gaps:	69/560 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VSSTSSSNNAEQQCSSSGLGLQLRQR-------MQITSSGCSSLAVTPMEHTPTE-----DD--- 72
            :|||||..:::::...|....:..|.       :|:|.....:|.: |..|.|..     |:
pombe    36 LSSTSSRKSSDEKSRKSSEDKRSPQSTVVQPGLLQVTIIEARNLKL-PSGHVPANYGVSIDNSLL 99

  Fly    73 ----ESGGGNSGVTSSVTTVTSSQRRQQLQQVQQQSALQAALEQHHISPTADLDSARKRPTHRTL 133
                .:|.|::...|....:..........::...:...|:||.......|..|.:|.......:
pombe   100 APPLSNGSGHARSRSHAWWLPYIVVEFDKNEILVDALNTASLENPCWDYQATFDVSRYSKLSLNI 164

  Fly   134 CPPPELMELSDSESQGGVETGGRREGATGRSAPDL------EDTEPLYETENEFELKEVIKEGHD 192
                 .:..|.|.|:.|:.......|.  :.:|..      ::..||:....|..::.:.|
pombe   165 -----YLRSSSSRSRNGMGNDAFLGGI--KLSPSFIVNKLTDEWVPLHGGSGELRVQMLYK---- 218

  Fly   193 KADPSQ--------FELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRST-N 248
               |:|        ||||:|:|:||||||..|||   :|...:||:|.:|||.:..:..|..| .
pombe   219 ---PNQSTPLTIDAFELLKVVGKGSFGKVMQVRK---RDTSRIYALKTMKKAHIVSRSEVDHTLA 277

  Fly   249 ERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMN 313
            ||.:||.|.:.|||.|.::||:||||||:|.|:.||:||..|.:|..|.....|||:|||.:|:.
pombe   278 ERTVLAQVNNPFIVPLKFSFQSPGKLYLVLAFVNGGELFHHLQREGCFDTYRAKFYIAELLVALE 342

  Fly   314 HLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL-DGSKTYSFCGTVEYMAPEIVNRKGHDF 377
            .||...:|||||||||||||..|||||.||||.|..: ...:|.:||||.||:|||::...|:..
pombe   343 CLHEFNVIYRDLKPENILLDYTGHIALCDFGLCKLNMAKTDRTNTFCGTPEYLAPELLLGHGYTK 407

  Fly   378 AADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLG 442
            ..|||:.|||:|||:||..||:.:...|...:||:..|..|:|:..:|:.||..|..|.|:.|||
pombe   408 VVDWWTLGVLLYEMITGLPPFYDENINEMYRKILQDPLRFPDNIDEKAKDLLSGLLTRAPEKRLG 472

  Fly   443 AGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTSKSPRDS--PGGPIS 504
            :|  |..:||.|.||..|||.:|..|:::|||.|:| |..|...||.|:||:.|.||  ....:|
pombe   473 SG--GAQEIKNHPFFDDIDWKKLCAKKIQPPFKPSVESAIDTSNFDSEFTSEIPMDSVVADSHLS 535

  Fly   505 ASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAP 544
            .:..:.|..:|:..|..::           ::..:::|||
pombe   536 ETVQQRFANWSYQRPTTID-----------TSDDINTIAP 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	126/259 (49%)
		STKc_RSK_N	203..517	CDD:270734	147/318 (46%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
gad8	NP_588010.1	YPK1_N_like	66..225	CDD:212165	28/173 (16%)
		PTZ00263	214..545	CDD:140289	153/342 (45%)
		STKc_YPK1_like	235..547	CDD:270737	146/316 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940