Protein Alignment S6kII and Akt1

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_150233.1
• Gene: Akt1 / 24185
• RGDID: 2081
• Length: 480
• Species: Rattus norvegicus
• Alignment Length: 530
• Identity: 169/530 - (31%)
• Similarity: 260/530 - (49%)
• Gaps: 114/530 - (21%)

  Fly    11 RQQPQQQQQQQHVSSTSSSNN-AEQQCSSSGLGLQLRQRMQITSSGCSSLAVTPM------EHTP 68
            :::||..:|::     |..|| :..||.     |...:|.:..:.....|..|.:      ..||
  Rat    39 KERPQDVEQRE-----SPLNNFSVAQCQ-----LMKTERPRPNTFIIRCLQWTTVIERTFHVETP 93

  Fly    69 TEDDESGGGNSGVTSSVTTVTSSQRRQQLQQVQQQSALQAALEQHHISPT-----ADLDSARKRP 128
            .|.:|       .|:::.||....:||:.:.:..:|.          ||:     .:::.|..:|
  Rat    94 EEREE-------WTTAIQTVADGLKRQEEETMDFRSG----------SPSDNSGAEEMEVALAKP 141

  Fly   129 THRTLCPPPELMELSDSESQGGVETGGRREGATGRSAPDLEDTEPLYETENEFELKEVIKEGHDK 193
            .||.                                            |.||
  Rat   142 KHRV--------------------------------------------TMNE------------- 149

  Fly   194 ADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRST-NERKILADVG 257
                 ||.|::||:|:||||.||::   |..|..||||:|||..:..||.|..| .|.::|.:..
  Rat   150 -----FEYLKLLGKGTFGKVILVKE---KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206

  Fly   258 HAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHT-LGII 321
            |.|:..|.|:|||..:|..::::..||:||..||:|.:|:|:..:||.||:..|:::||: ..::
  Rat   207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271

  Fly   322 YRDLKPENILLDEHGHIALTDFGLSKQPL-DGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFG 385
            |||||.||::||:.|||.:|||||.|:.: ||:...:||||.||:|||::....:..|.|||..|
  Rat   272 YRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLG 336

  Fly   386 VLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILD 450
            |:||||:.|.|||:.|..::....||..::..|..|.|||:|||..|.|::|..|||.|::...:
  Rat   337 VVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKE 401

  Fly   451 IKAHCFFATIDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTSK----SPRDSPGGP--ISASAH 508
            |..|.|||.|.|..:..|::.|||.|.| |..|..|||.|:|::    :|.|.....  :.:...
  Rat   402 IMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERR 466

  Fly   509 EIFRGFSFVA 518
            ..|..||:.|
  Rat   467 PHFPQFSYSA 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	134/323 (41%)
		STKc_RSK_C	567..883	CDD:270993
Akt1	NP_150233.1	PH_PKB	4..111	CDD:269947	19/88 (22%)
		STKc_PKB_alpha	124..479	CDD:270746	147/418 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..480		6/26 (23%)