Protein Alignment S6kII and Rskr

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_001391729.1
• Gene: Rskr / 216976
• MGIID: 2652869
• Length: 406
• Species: Mus musculus
• Alignment Length: 324
• Identity: 98/324 - (30%)
• Similarity: 174/324 - (53%)
• Gaps: 31/324 - (9%)

  Fly   180 EFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRV 244
            ||.::.|       .:..:.::|.::.:||||.|.   |::......::|:||:.|..:..:|.:
Mouse    89 EFPVRPV-------REQQELKILGLVAKGSFGTVL---KVLDCAQKAVFAVKVVPKVKVLQRDTL 143

  Fly   245 RSTNER-KILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 308
            |...|. .|...:.|.|:..|..::|....|:::..:. ..||::..|....|.|:.::.:.|||
Mouse   144 RQCKEEVSIQRQINHPFVHSLGDSWQGKQHLFIMCSYC-SMDLYSLWSTVGWFPEDSIRLFAAEL 207

  Fly   309 ALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLDGSKTYSFCGTVEYMAPEIVNRK 373
            .|.:.:||.||||:||:|.|||||||.||:.:||||||:....|::.|:.|||::|||||:::..
Mouse   208 VLVLCYLHDLGIIHRDVKMENILLDERGHLKVTDFGLSRHLSQGARAYTICGTLQYMAPEVLSGG 272

  Fly   374 GHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETM-NQILRSKLGMPENLSPEAQSLLRALFKRNP 437
            .::..|||||.|||::.:.||..|...:.....| ..:...:..:|.:::.|...||..|..:||
Mouse   273 PYNHTADWWSLGVLLFSLATGKFPVAAERDHVAMLASVAHCESEIPASINQELSLLLHELLCQNP 337

  Fly   438 QNRLGAGAQGILDIKAHCFF------------ATIDWVRLERKQVRPPFIPAVSRDDAFYFDVE 489
            .:||    :.:...:.|.||            ..:::| :|::...|..:.::|.:| |.:|:|
Mouse   338 LHRL----RYLHHFQVHPFFRGVAFDPELLQKQPVNFV-MEKQDTWPSPLESMSFED-FDYDLE 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	94/301 (31%)
		STKc_RSK_C	567..883	CDD:270993
Rskr	NP_001391729.1	Protein Kinases, catalytic domain	109..353	CDD:473864	84/251 (33%)