DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6kII and AKT1

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001014431.1	Gene:	AKT1 / 207	HGNCID:	391	Length:	480	Species:	Homo sapiens

Alignment Length:	448	Identity:	160/448 - (35%)
Similarity:	247/448 - (55%)	Gaps:	33/448 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 RQQLQQVQQQSALQAALEQHHISPTADLDSARKRP-THRTLCPPPELMELSDSESQGGVETGGRR 157
            :::.|.|.|:   :|.|....::....:.:.|.|| |....|    |...:..|....|||...|
Human    39 KERPQDVDQR---EAPLNNFSVAQCQLMKTERPRPNTFIIRC----LQWTTVIERTFHVETPEER 96

  Fly   158 EGATGRSAPDLEDTEPLYETENEF------------ELKEVIKEGHDKADPSQFELLRVLGEGSF 210
            |..|.......:..:...|.|.:|            |::..:.:...:...::||.|::||:|:|
Human    97 EEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTF 161

  Fly   211 GKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRST-NERKILADVGHAFIVRLHYAFQTPGKL 274
            |||.||::   |..|..||||:|||..:..||.|..| .|.::|.:..|.|:..|.|:|||..:|
Human   162 GKVILVKE---KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL 223

  Fly   275 YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHT-LGIIYRDLKPENILLDEHGHI 338
            ..::::..||:||..||:|.:|:|:..:||.||:..|:::||: ..::|||||.||::||:.|||
Human   224 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI 288

  Fly   339 ALTDFGLSKQPL-DGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQT 402
            .:|||||.|:.: ||:...:||||.||:|||::....:..|.|||..||:||||:.|.|||:.|.
Human   289 KITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 353

  Fly   403 RQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLER 467
            .::....||..::..|..|.|||:|||..|.|::|:.|||.|::...:|..|.|||.|.|..:..
Human   354 HEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYE 418

  Fly   468 KQVRPPFIPAV-SRDDAFYFDVEYTSK----SPRDSPGGP--ISASAHEIFRGFSFVA 518
            |::.|||.|.| |..|..|||.|:|::    :|.|.....  :.:.....|..||:.|
Human   419 KKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	114/260 (44%)
		STKc_RSK_N	203..517	CDD:270734	134/323 (41%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
AKT1	NP_001014431.1	PH_PKB	4..111	CDD:269947	18/78 (23%)
		Inositol-(1,3,4,5)-tetrakisphosphate binding	14..19
		Inositol-(1,3,4,5)-tetrakisphosphate binding	23..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..138		4/24 (17%)
		STKc_PKB_alpha	124..479	CDD:270746	139/356 (39%)
		Inhibitor binding	228..230		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..480		6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940