DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6kII and Sgk1

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001155317.2	Gene:	Sgk1 / 20393	MGIID:	1340062	Length:	524	Species:	Mus musculus

Alignment Length:	448	Identity:	170/448 - (37%)
Similarity:	239/448 - (53%)	Gaps:	69/448 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 PPELMELSDSESQGGVETGGRREGATGRSAPD------LEDTEPLYETE---NEF---------- 181
            |||  |....|.|.|.|...:...|...:.||      .:|...:.:..   |:|
Mouse    79 PPE--ESCSWEIQPGCEVKEQCNHANILTKPDPRTFWTNDDAAFMKQRRMGLNDFIQKIASNTYA 141

  Fly   182 ----ELKEVIKEGHDK----------------------------ADPSQFELLRVLGEGSFGKVF 214
                |::.::|..|.:                            |.||.|..|:|:|:||||||.
Mouse   142 CKHAEVQSILKMSHPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVL 206

  Fly   215 LVRKIIGKDAGTLYAMKVL-KKATLKVKDRVRSTNERKI-LADVGHAFIVRLHYAFQTPGKLYLI 277
            |.|.   |.....||:||| |||.||.|:.....:||.: |.:|.|.|:|.||::|||..|||.:
Mouse   207 LARH---KAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 268

  Fly   278 LDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTD 342
            ||::.||:||..|.:|..|.|...:||.||:|.|:.:||:|.|:||||||||||||..|||.|||
Mouse   269 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD 333

  Fly   343 FGLSKQPLDGSKTYS-FCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQET 406
            |||.|:.::.:.|.| ||||.||:|||:::::.:|...|||..|.::||||.|..||:.:...|.
Mouse   334 FGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEM 398

  Fly   407 MNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVR 471
            .:.||...|.:..|::..|:.||..|.:::...|||| ....::||:|.||:.|:|..|..|::.
Mouse   399 YDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA-KDDFMEIKSHIFFSLINWDDLINKKIT 462

  Fly   472 PPFIPAVS-RDDAFYFDVEYTSKSPRDSPG-GP----ISAS---AHEIFRGFSFVAPV 520
            |||.|.|| ..|..:||.|:|.:....|.| .|    ::||   |.|.|.|||:..||
Mouse   463 PPFNPNVSGPSDLRHFDPEFTEEPVPSSIGRSPDSILVTASVKEAAEAFLGFSYAPPV 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	120/260 (46%)
		STKc_RSK_N	203..517	CDD:270734	146/325 (45%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
Sgk1	NP_001155317.2	STKc_SGK1	183..521	CDD:270753	153/342 (45%)
Sgk1	NP_001155317.2	S_TKc	191..448	CDD:214567	120/260 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940