DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6kII and Rps6ka1

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001365809.1	Gene:	Rps6ka1 / 20111	MGIID:	104558	Length:	741	Species:	Mus musculus

Alignment Length:	744	Identity:	435/744 - (58%)
Similarity:	535/744 - (71%)	Gaps:	64/744 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 ETENEFELKEV-----IKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKK 235
            :..:|..|||:     :|.|.:||||||||||:|||:|||||||||||:...|:|.|||||||||
Mouse    40 QDSDEAILKEISITHHVKAGSEKADPSQFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKK 104

  Fly   236 ATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEED 300
            |||||:||||:..||.|||||.|.|:|:|||||||.|||||||||||||||||||||||||||||
Mouse   105 ATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEED 169

  Fly   301 VKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYSFCGTVEY 364
            ||||||||||.::|||:|||||||||||||||||.|||.||||||||:.:| ..|.|||||||||
Mouse   170 VKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEY 234

  Fly   365 MAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLL 429
            ||||:|||:||..:|||||:||||:|||||:|||.|:.|:|||..||::|||||:.||.||||||
Mouse   235 MAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLL 299

  Fly   430 RALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFYFDVEYTSK 493
            ||||||||.||||:|..|..:||.|.|::||||.:|.|::::|||.|||:: ||.||||.|:||:
Mouse   300 RALFKRNPANRLGSGPDGAEEIKRHIFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSR 364

  Fly   494 SPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPG 558
            :||||||.|.||.||::||||||||..|:|    ......|:.:||||:..
Mouse   365 TPRDSPGIPPSAGAHQLFRGFSFVATGLME----DDGKPRTTQAPLHSVVQ-------------- 411

  Fly   559 VLPGN---FHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVE 620
            .|.|.   |...|.:.:.:|.|::|||:.|.|:|:...||||||:|         :..|..||:|
Mouse   412 QLHGKNLVFSDGYVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDK---------SKRDPSEEIE 467

  Fly   621 IMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYL 685
            |:||||.||||:||..||:|....|||.||::||||||:||......|.|||.||.||:..|.||
Mouse   468 ILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYL 532

  Fly   686 HEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGY 750
            |..|||||||||||::|......||.|::||.||||||||:||||||||||||||||||||||||
Mouse   533 HSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGY 597

  Fly   751 DLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQML 815
            |..|||||||:|||.||:|.||||:.|:|:|:.||.|||||:...:...|..:|..||:|:.:||
Mouse   598 DEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKML 662

  Fly   816 HIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMAL-RGAVDATF 879
            |:.|..|.||.::|:|.|          :|:....|.||||         |..:.| :||:.||:
Mouse   663 HVDPHQRLTAKQVLQHPW----------ITQKDKLPQSQLS---------HQDLQLVKGAMAATY 708

  Fly   880 RAI----AIPQAANVGPVELSMLAKRRAK 904
            .|:    ..||   :.|:|.|:||:||.:
Mouse   709 SALNSSKPTPQ---LKPIESSILAQRRVR 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	199/258 (77%)
		STKc_RSK_N	203..517	CDD:270734	233/315 (74%)
		STKc_RSK_C	567..883	CDD:270993	164/320 (51%)
		S_TKc	568..834	CDD:214567	150/265 (57%)
Rps6ka1	NP_001365809.1	STKc_RSK_N	72..388	CDD:270734	233/315 (74%)
Rps6ka1	NP_001365809.1	STKc_RSK1_C	422..712	CDD:271077	164/317 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	396	1.000	Domainoid score	I752
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	824	1.000	Inparanoid score	I464
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55819
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		otm43821
orthoMCL	1	0.900	-	-		OOG6_101790
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.800