Protein Alignment S6kII and Prkg1

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_035290.1
• Gene: Prkg1 / 19091
• MGIID: 108174
• Length: 686
• Species: Mus musculus
• Alignment Length: 502
• Identity: 155/502 - (30%)
• Similarity: 243/502 - (48%)
• Gaps: 95/502 - (18%)

  Fly    82 TSSVTTVTSSQ----RRQQLQQVQQQSALQAALEQHHISPTADLDSARKRPTHRTLCPPPELMEL 142
            |::|.|:.:.:    .||..|.:..::.|        |..|..::..:..||.::| |...|.:|
Mouse   193 TATVKTLVNVKLWAIDRQCFQTIMMRTGL--------IKHTEYMEFLKSVPTFQSL-PDEILSKL 248

  Fly   143 SDSESQGGVETGGR--REGATGR------------SAPDLEDTEPLY------------------ 175
            :|...:...|.|..  |:||.|.            :..|....:|::
Mouse   249 ADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGE 313

  Fly   176 --ETEN---------------EFE-----LKEVIKEGHDKADP----------------SQFELL 202
              .|.|               .|:     |.:|..:.::.|:.                |.|.::
Mouse   314 DVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNII 378

  Fly   203 RVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATL---KVKDRVRSTNERKILADVGHAFIVRL 264
            ..||.|.||:|.||:  :..:....:|||:|||..:   :.::.:||  |::|:......|||||
Mouse   379 DTLGVGGFGRVELVQ--LKSEESKTFAMKILKKRHIVDTRQQEHIRS--EKQIMQGAHSDFIVRL 439

  Fly   265 HYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPEN 329
            :..|:....||::::...||:|:|.|.....|.:...:||.|.:..|..:||:.|||||||||||
Mouse   440 YRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPEN 504

  Fly   330 ILLDEHGHIALTDFGLSKQPLDGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTG 394
            ::||..|:..|.|||.:|:...|.||::||||.||:||||:..||||.:||:||.|:||||:|||
Mouse   505 LILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTG 569

  Fly   395 NLPFHGQTRQETMNQILR--SKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFF 457
            :.||.|....:|.|.|||  ..:..|:.::..|.:|::.|.:.||..|||....|:.||:.|.:|
Mouse   570 SPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF 634

  Fly   458 ATIDWVRLERKQVRPPFIPAV-SRDDAFYFD--VEYTSKSPRDSPGG 501
            ...:|..|.:..:.||.||:| |..|...||  .|.:.:.|.|...|
Mouse   635 EGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSG 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	123/307 (40%)
		STKc_RSK_C	567..883	CDD:270993
Prkg1	NP_035290.1	DD_cGKI-beta	4..55	CDD:213375
		CAP_ED	118..227	CDD:237999	9/41 (22%)
		CAP_ED	237..341	CDD:237999	16/104 (15%)
		STKc_cGK	381..641	CDD:270724	109/263 (41%)
		S_TK_X	636..>679	CDD:214529	14/42 (33%)