Protein Alignment S6kII and egl-4

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_001294450.1
• Gene: egl-4 / 176991
• WormBaseID: WBGene00001173
• Length: 783
• Species: Caenorhabditis elegans
• Alignment Length: 479
• Identity: 136/479 - (28%)
• Similarity: 217/479 - (45%)
• Gaps: 81/479 - (16%)

  Fly    81 VTSSVTTVTSSQRRQQLQQVQQQSALQAALEQHHISPTAD------------------------- 120
            |...:|.....:|..||.....:.::...|.:..||..||
 Worm   294 VFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKCLQGDA 358

  Fly   121 ---LDSARKRPTHRT--LCPPPELMELSDSESQG-------------------GVETGGRREGAT 161
               ::|.:.:.|.:.  ...|.|:..|:..:..|                   |||.......:.
 Worm   359 FFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESF 423

  Fly   162 GRSAPDLEDTEPLYETENEFELKEVIKEGHDKADPSQFEL------------------LRVLGEG 208
            |:...|||..:..|..:.  .|.:|::|     .||..::                  |..||.|
 Worm   424 GKLIGDLESLKKDYGDKE--RLAQVVRE-----PPSPVKIVDDFREEFAQVTLKNVKRLATLGVG 481

  Fly   209 SFGKVFLVRKIIGKDAGTLYAMKVLKKA-TLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPG 272
            .||:|.||  .:..|....:|:|.|||. .:..:.:.....||.|:.:....:||:|:..|:...
 Worm   482 GFGRVELV--CVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQK 544

  Fly   273 KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGH 337
            .:|::|:...||:|:|.|.....|.:...:||:|.:...:.:||...|:||||||||.||...|:
 Worm   545 FVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGY 609

  Fly   338 IALTDFGLSKQPLDGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQT 402
            :.|.|||.:|:...|.||::||||.||::|||:..||||.|||:|:.|:.:.|::.|..||....
 Worm   610 LKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASD 674

  Fly   403 RQETMNQILR--SKLGMP-ENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVR 464
            ..:|...||:  ..|.:| ..:...|.:|::.|.:.||..|||:|:.|:.||:.|.:|...||..
 Worm   675 PMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEG 739

  Fly   465 LERKQVRPPFIPAVSRD-DAFYFD 487
            |..:.::||.:|.||.. |...||
 Worm   740 LRSRTLKPPILPKVSNPADVTNFD 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	106/290 (37%)
		STKc_RSK_C	567..883	CDD:270993
egl-4	NP_001294450.1	CAP_ED	201..314	CDD:237999	5/19 (26%)
		CAP_ED	319..437	CDD:237999	18/117 (15%)
		STKc_cGK	478..739	CDD:270724	97/262 (37%)
		S_TK_X	734..783	CDD:214529	11/30 (37%)