DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment S6kII and pkc-3

DIOPT Version :10

Sequence 1:NP_523437.2 Gene:S6kII / 33139 FlyBaseID:FBgn0262866 Length:911 Species:Drosophila melanogaster
Sequence 2:NP_495011.1 Gene:pkc-3 / 173914 WormBaseID:WBGene00004034 Length:597 Species:Caenorhabditis elegans


Alignment Length:438 Identity:146/438 - (33%)
Similarity:220/438 - (50%) Gaps:54/438 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 ALEQHHISPTADLDSARKRPTHRTLCPPPELMELSDSESQGGVETGGRRE------GATGRSAPD 167
            ||:..:|.|.|....:.|.....|        ..|.:.|.||::.|...|      |:|...|. 
 Worm   180 ALQGPNIIPMAPASGSLKGARSNT--------SSSTTRSGGGIDNGAFHEHEIESPGSTSHDAS- 235

  Fly   168 LEDTEPLYETENEFELKEVIKEGHDK--ADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAM 230
                            :.:...|..|  ...:.|.||.|:|.||:.||.....:..:.   :||:
 Worm   236 ----------------RAMNGNGSSKWAVSLNDFRLLTVIGRGSYAKVVQAEHVSTRQ---IYAI 281

  Fly   231 KVLKKATLKVKDRVR--STNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKE 293
            |::||......:.:.  .|.:....|...:.|:|.||..|||..:|:.:::|:.||||...:.::
 Worm   282 KIIKKEMFNEDEDIDWVQTEKSVFEAASNYPFLVGLHSCFQTESRLFFVIEFVPGGDLMFHMQQQ 346

  Fly   294 VMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL-DGSKTYS 357
            ....||..:||..|:.||::.||:.||||||||.:|:|:|..|||.|||:|:.|:.: ||..|.:
 Worm   347 RKLPEEHARFYSGEIILALHFLHSRGIIYRDLKLDNVLIDAEGHIKLTDYGMCKENIKDGDLTST 411

  Fly   358 FCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFH--GQTRQETMNQ------ILRSK 414
            ||||..|:||||:....:.|:.|||:.||||:||:.|..||.  |....|...:      ||..:
 Worm   412 FCGTPNYIAPEILRGDEYGFSVDWWALGVLMFEMMAGRSPFDIVGMQNSEENTEDYLFQIILERQ 476

  Fly   415 LGMPENLSPEAQSLLRALFKRNPQNRLGAGA---QGILDIKAHCFF-ATIDWVRLERKQVRPPFI 475
            :.:|.:||..|..:|:....::|..|||...   :|:.|:|.|.|| ..|||..||:|.|.||:.
 Worm   477 IRIPRSLSVRASGILKGFLNKDPTERLGCKLDINEGLRDMKEHQFFRGFIDWEALEQKAVAPPYH 541

  Fly   476 PAVSRD-DAFYFDVEYTSKSPRDSPGGP--ISASAHEIFRGFSFVAPV 520
            |||..| |..:||.::|.:.|:.||..|  |:......|.||.:|.|:
 Worm   542 PAVESDRDLTHFDHQFTDELPQLSPDNPDVIARIDQSEFDGFEYVNPL 589

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
S6kIINP_523437.2 STKc_RSK_N 203..517 CDD:270734 123/331 (37%)
STKc_RSK_C 567..883 CDD:270993
pkc-3NP_495011.1 PB1_aPKC 13..95 CDD:99725
C1_aPKC 126..180 CDD:410344 146/438 (33%)
STKc_aPKC 257..586 CDD:270740 123/331 (37%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.