Protein Alignment S6kII and rskn-1

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_001122504.1
• Gene: rskn-1 / 172647
• WormBaseID: WBGene00011352
• Length: 804
• Species: Caenorhabditis elegans
• Alignment Length: 737
• Identity: 393/737 - (53%)
• Similarity: 518/737 - (70%)
• Gaps: 55/737 - (7%)

  Fly   177 TENEFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVK 241
            :|.|.::.:|.|.| :||||.|||||:|||:|||||||||||:.|:|:|.:|||||||||||||:
 Worm    77 SETEIDIGDVRKCG-EKADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVR 140

  Fly   242 DRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 306
            ||.|:..||.|||.:.|.|||:|||||||.|||||||||||||||||||||||||||:|||||||
 Worm   141 DRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLA 205

  Fly   307 ELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLDG-SKTYSFCGTVEYMAPEIV 370
            ||.||:.|||:|||:||||||||||||..|||.:|||||||:.:|. .|||||||||||||||::
 Worm   206 ELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVI 270

  Fly   371 NRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKR 435
            ||:||..|||:||.||||:|||||:|||.|:.|.:||.|||::||.||..|:.||||||||||||
 Worm   271 NRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKR 335

  Fly   436 NPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFYFDVEYTSKSPRDSP 499
            |.|||||||..|:.:||.|.|||.||:|:|..|::.|||.||:|. |...|||.|:|.::|:|||
 Worm   336 NSQNRLGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSP 400

  Fly   500 GGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPGVLPGNF 564
            ..|.||:.||||||||||:..::|.:...:.          |:..:|.|     :|.|      |
 Worm   401 ALPASANGHEIFRGFSFVSNAVMEERKLIAK----------SVRSVPTA-----KTNP------F 444

  Fly   565 HAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHP 629
            ..:|.:|:::|.|..||...|:.:|:::.||||:::||..         |..|||:|:||:.:|.
 Worm   445 TDDYEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVF---------DATEEVDILLRHSHHQ 500

  Fly   630 NIVTLYSVYEDAGSAYLVMELLKGGELLDRIL---AVGQMCESEASAVLRTIASAVAYLHEHGVV 691
            .:|.|:.||||..:.|::.||.:||||||:::   ::|.  |.|.:|::..:.:||.|||...|.
 Worm   501 FVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGS--EKEVAAIMANLLNAVQYLHSQQVA 563

  Fly   692 HRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDI 756
            ||||..:|:::|.....|.:|::.|.|||||.||:||:||||||||.|||||||::||||.:||:
 Worm   564 HRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDV 628

  Fly   757 WSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPEN 821
            |||||||:.||:|.||||..|||:||.||:|:|.|:|..|...|..||..||:|:|:||.:.|..
 Worm   629 WSLGVLLHTMLTGCTPFAMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNR 693

  Fly   822 RPTAARILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISM---ALRGAVDATFRAIA 883
            |.||.:.|:|.|:.::.|          .|...:    |.:|...:.|   ..:.|::.|::|||
 Worm   694 RVTAKQALQHKWIGQKEA----------LPDRPI----QSEQVGELDMQNVKFQVALEQTYKAIA 744

  Fly   884 IPQAANVGPVELSMLAKRRAKD 905
            ...:..:.||..|.|||||.|:
 Worm   745 SAPSVQLRPVGSSALAKRRMKE 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	223/315 (71%)
		STKc_RSK_C	567..883	CDD:270993	136/321 (42%)
rskn-1	NP_001122504.1	STKc_RSK_N	102..418	CDD:270734	223/315 (71%)
		STKc_RSK_C	447..744	CDD:270993	136/321 (42%)