DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and rskn-2

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001348666.1	Gene:	rskn-2 / 172581	WormBaseID:	WBGene00008311	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	704	Identity:	259/704 - (36%)
Similarity:	397/704 - (56%)	Gaps:	65/704 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 LKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRV--R 245
            :::::....:|.....|.||||||:|::||||||||:.|||..|:||||||:|..:..|.:.  .
Worm     1 MEDILMPEGEKVSMENFALLRVLGKGAYGKVFLVRKVGGKDHNTIYAMKVLRKTRVLTKQKTLEH 65

  Fly   246 STNERKILADV-GHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 309
            :..||::|..: |..|:|.|.|||||..||:::::::|||:|||.|.....|..|..:|.:|||.
Worm    66 TMAERQVLERLRGTPFLVNLFYAFQTDTKLHIVMEYVRGGELFTHLCSRGHFDLEAARFVIAELV 130

  Fly   310 LAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLDG--SKTYSFCGTVEYMAPEIVNR 372
            :|::.||...:||||||.|||||||.||:.||||||||..|.|  .:..|:|||:|||:||::||
Worm   131 VAIDSLHQRKVIYRDLKLENILLDEEGHVKLTDFGLSKLFLPGELDRANSYCGTIEYMSPEVINR 195

  Fly   373 K--GHDFAADWWSFGVLMYEMLTGNLPF----HGQTRQETMNQILRSKLGMPENLSPEAQSLLRA 431
            .  |:....||||.||:.:|:|||..||    ...:.::...:|:..|:..|:.:..:|:..:..
Worm   196 PEGGYSDVVDWWSLGVISFELLTGCSPFTVDGAQNSSKDIAKRIMTKKVPFPKTMDVDARDFIGQ 260

  Fly   432 LFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSRD-DAFYFDVEYTSKSP 495
            |.::..:.||  |..|:.:||.|.|.::|||....::.::|..:|.:..| |..:|..|:||:.|
Worm   261 LLEKKLEKRL--GYNGVDEIKNHKFMSSIDWDAAVKRTLKPVIVPRIGHDLDTQFFSAEFTSQPP 323

  Fly   496 RDSPG-GPISASAHEIFRGFSFVAP--VLLEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLP 557
            ..||. .|::|:.  :|||:|:|:|  :.......|..:.:...:.|
Worm   324 LYSPAESPLNANT--LFRGYSYVSPSVIFANDNVIGEELMAEDVNAL------------------ 368

  Fly   558 GVLPGNFHAEYNLLQE----LGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEE 618
             :...:|.|:|.|.:.    ||:|.|||.|.||.......:|||::.:...:.|.        .|
Worm   369 -LASSSFFAKYKLDKSDAGLLGKGAFSVVRRCERVVDGAQFAVKIVSQKFASQAQ--------RE 424

  Fly   619 VEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVA 683
            ..|:.....|||||.|:.|:.|....|||||:|.|.|||:||..:.:..||||:.::|.:.|||.
Worm   425 ARILEMVQGHPNIVQLHDVHSDPLHFYLVMEILTGNELLERIRKLERFTESEAADIMRQLVSAVK 489

  Fly   684 YLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAK--------QLRADNGL-LMTPCYTANF 739
            |||:..:|||||||.|:::.|: .:...|:|.|.|||:        ||::...| .||||:|..:
Worm   490 YLHDKRIVHRDLKPENILFESI-DSSARLRLVDFGFARLLPNSMEQQLKSVQVLRKMTPCFTLQY 553

  Fly   740 VAPEVL----KRQGYDLACDIWSLGVLLYIMLSGRTPF-ASTPNDSPDVILKRIGSGQIDFTSSR 799
            .|||||    .:..|:..||:|||||:|:.||||:.|| |.:..:|...|::||...:..||...
Worm   554 AAPEVLDVGDSQPEYNEQCDLWSLGVVLFTMLSGQVPFHARSRQESATEIMQRICRAEFSFTGDA 618

  Fly   800 WALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGS 853
            |..:|..||.|:..:|.:.|:.|.:...:..|.||:...:....|...::.|.|
Worm   619 WTNVSADAKNLITGLLTVDPKKRLSMQELTAHMWLKSSASMDTPLQTPSILPSS 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	119/268 (44%)
		STKc_RSK_N	203..517	CDD:270734	137/326 (42%)
		STKc_RSK_C	567..883	CDD:270993	112/305 (37%)
		S_TKc	568..834	CDD:214567	107/283 (38%)
rskn-2	NP_001348666.1	PKc_like	22..287	CDD:328722	116/266 (44%)
		S_TK_X	285..344	CDD:214529	20/60 (33%)
		STKc_MSK_C	374..694	CDD:270994	114/308 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950