Protein Alignment S6kII and aPKC

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: XP_061518621.1
• Gene: aPKC / 1280683
• VectorBaseID: AGAMI1_009490
• Length: 826
• Species: Anopheles gambiae
• Alignment Length: 805
• Identity: 212/805 - (26%)
• Similarity: 294/805 - (36%)
• Gaps: 307/805 - (38%)

  Fly     7 QKDLRQQPQQQQQQQHVS------STSSSNNAEQQCSSSGLGL---------------------- 43
            |:.::||.||||||.|..      ::|.|......||:..|..
Mosquito    34 QQPVQQQQQQQQQQHHHQQQQYSLASSQSQQPSMHCSALSLNTCPQAVELPSIQQQQLICSNGSQ 98

  Fly    44 ------QLRQRMQITSSGCSSLAVTP--MEHTPTEDDESGGGNSGVTSSVTTVTSSQRRQQLQQV 100
                  |.:|:.||.||.|.|...:|  :|..|.|            ...|..|.| |||.|...
Mosquito    99 PSLHHQQQQQQQQICSSPCHSPCHSPQFIEQLPPE------------LPCTPCTFS-RRQSLDSP 150

  Fly   101 Q----QQSALQAALEQHHIS-------------------------PTADLDSARKRP-THR---T 132
            |    |..||....|.:.:|                         .|.|.......| ||.   |
Mosquito   151 QVDRCQSLALLGCAEANQLSDIICRATQPSIQSAGNTLTRGTSLRDTGDYAVPHPHPHTHHYMST 215

  Fly   133 LCPPPELMEL-----------------SDSESQGGVETGGRREGATGRSA--------------- 165
            ...||.|..:                 |.|...||..:||...|:.|...
Mosquito   216 SATPPSLSRVGSCPGSTGGSGSGHGSGSGSSPGGGPGSGGGGSGSVGGGGGVGSGVSICGGSILG 280

  Fly   166 ------------------------------PDL---EDTEPLYET-------------------- 177
                                          |.|   ::.||.|.|
Mosquito   281 GSQGRLEYIECSHYDRMPLPIPVQIPIVPPPQLHSEDEIEPAYATVFPNVPSAPGLSCVGEDRSI 345

  Fly   178 ----------------------------------------------------------------- 177
                                                                             
Mosquito   346 YRRGARRWRKLYRINGHIFQAKRFNRKAFCAFCHDRIWGLGRQGFKCIQCKLLVHKKCHKLGNKP 410

  Fly   178 -ENEFELKEVIKE--GHDKAD--------------PSQ--------------------------- 198
             .|| .::.|.||  .||..|              ||:
Mosquito   411 CSNE-HVEPVFKERDHHDPNDESSTGDVIQAPLDYPSELHSGDGCDQVPVEVNDNVEETLEPVTQ 474

  Fly   199 -------FELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADV 256
                   |||:||:|.||:.||.:|..   |....:|||||:|||.:...:.:......|.:.:.
Mosquito   475 RQYSLNDFELIRVIGRGSYAKVLMVEL---KKTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFET 536

  Fly   257 --GHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLG 319
              .|.|:|.||..||||.:|:.:::|:|||||...:.::....||..:||.||::||:|.||..|
Mosquito   537 ASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMFHMQRQRRLPEEHARFYAAEISLALNFLHEKG 601

  Fly   320 IIYRDLKPENILLDEHGHIALTDFGLSKQPL-DGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWS 383
            |||||||.:|:|||..|||.|||:|:.|:.: .|..|.:||||..|:||||:..:.:.|:.|||:
Mosquito   602 IIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWA 666

  Fly   384 FGVLMYEMLTGNLPFHGQTRQETMNQ---------ILRSKLGMPENLSPEAQSLLRALFKRNPQN 439
            .|||:||||.|..||......|..:|         ||...:.:|.:||.:|.|:|:....:||.:
Mosquito   667 LGVLLYEMLAGRSPFDIAGASENPDQNTEDYLFQVILEKTIRIPRSLSVKAASVLKGFLNKNPAD 731

  Fly   440 RLGAGA-QGILDIKAHCFFATIDWVRLERKQVRPPFIPA---VSRDDAFYFDVEYTSKSPRD-SP 499
            |||... ...|||..|.||.:|||..|.:|:|.||:||:   ..:|...:||.::| :.|.| :|
Mosquito   732 RLGCNRDSAFLDIMNHSFFKSIDWEMLAQKEVTPPYIPSFDGCDQDITCHFDPQFT-REPADLTP 795

  Fly   500 GGP--ISASAHEIFRGFSFVAPVLL 522
            ..|  |.......|.||.:|.|:|:
Mosquito   796 DDPRVIDKIDQSEFEGFEYVNPLLM 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	133/332 (40%)
		STKc_RSK_C	567..883	CDD:270993
aPKC	XP_061518621.1	None