Protein Alignment S6kII and Rps6ka2

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: XP_038934903.1
• Gene: Rps6ka2 / 117269
• RGDID: 620676
• Length: 762
• Species: Rattus norvegicus
• Alignment Length: 786
• Identity: 449/786 - (57%)
• Similarity: 556/786 - (70%)
• Gaps: 76/786 - (9%)

  Fly   135 PPPELMELSDSESQGGVETGGRREGATGRSAPDLEDTEPLYET---ENEFELKEV-----IKEGH 191
            |.||     |:..:|        :|.|..||    :|:|...:   |.|..:||:     :|||.
  Rat    33 PTPE-----DTTEEG--------KGDTTASA----ETQPASSSSSAEEEGIVKEIDISSHVKEGF 80

  Fly   192 DKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADV 256
            :||||||||||:|||:||:||||||||:.|.|||.||||||||||||||:|||||..||.|||:|
  Rat    81 EKADPSQFELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEV 145

  Fly   257 GHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGII 321
            .|.|||:|||||||.||||||||||||||||||||||||||||||||||||||||::|||.||||
  Rat   146 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGII 210

  Fly   322 YRDLKPENILLDEHGHIALTDFGLSKQPLDGSK-TYSFCGTVEYMAPEIVNRKGHDFAADWWSFG 385
            |||||||||||||.|||.:|||||||:.:|..| .||||||:||||||:|||:||..:|||||||
  Rat   211 YRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFG 275

  Fly   386 VLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILD 450
            |||:|||||:|||.|:.|:|||..||::|||||:.||.||||||||||||||.||||||..|:.:
  Rat   276 VLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSAEAQSLLRALFKRNPCNRLGAGVDGVEE 340

  Fly   451 IKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFYFDVEYTSKSPRDSPGGPISASAHEIFRGF 514
            ||.|.||.||||.:|.||:::|||.|||.| :|.|:||.|:|:::|.||||.|.||:||.:||||
  Rat   341 IKRHPFFVTIDWNKLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGF 405

  Fly   515 SFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPGVLPGN---FHAEYNLLQELGR 576
            ||||..|::             .|  |...:|.||:   ..:...|.||   |...|.:.:::|.
  Rat   406 SFVASSLVQ-------------EP--SQQDVPKAPI---HPIVQQLHGNNIHFTDGYEIKEDIGV 452

  Fly   577 GTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDA 641
            |::|||:.|.|:|:...||||:|:|         :..|..||:||:||||.||||:||..||:|.
  Rat   453 GSYSVCKRCVHKATDAEYAVKIIDK---------SKRDPSEEIEILLRYGQHPNIITLKDVYDDG 508

  Fly   642 GSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMR 706
            ...||||||::|||||||||......|.|||.||.|||..:.|||..|||||||||||::|....
  Rat   509 KYVYLVMELMRGGELLDRILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDES 573

  Fly   707 QTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRT 771
            ..||::::||.||||||||:|||||||||||||||||||||||||.|||:||||:|||.||:|.|
  Rat   574 GNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDVWSLGILLYTMLAGFT 638

  Fly   772 PFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLRE 836
            |||:.|:|:|:.||.|||||:...:...|..||..||:::.:|||:.|:.|.||.::|:|.|:..
  Rat   639 PFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPQQRLTAVQVLKHPWIVN 703

  Fly   837 QFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALRGAVDATFRAI-AIPQAANVGPVELSMLAK 900
            :        ||       ||.....:|..|:   ::||:.||:.|: ..|||..:.||..|.||:
  Rat   704 R--------EY-------LSQNQLSRQDVHL---VKGAMAATYFALNRTPQAPRLEPVLSSSLAQ 750

  Fly   901 RRAKDR 906
            ||...|
  Rat   751 RRGMKR 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	235/315 (75%)
		STKc_RSK_C	567..883	CDD:270993	162/316 (51%)
Rps6ka2	XP_038934903.1	STKc_RSK_N	92..408	CDD:270734	235/315 (75%)
		STKc_RSK3_C	440..732	CDD:271080	163/318 (51%)