DRSC/TRiP Functional Genomics Resources

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Protein Alignment S6kII and Akt1

DIOPT Version :9

Sequence 1:NP_001259779.1 Gene:S6kII / 33139 FlyBaseID:FBgn0262866 Length:911 Species:Drosophila melanogaster
Sequence 2:NP_001159366.1 Gene:Akt1 / 11651 MGIID:87986 Length:488 Species:Mus musculus


Alignment Length:476 Identity:163/476 - (34%)
Similarity:252/476 - (52%) Gaps:61/476 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 RQQLQQVQQQSALQAALEQHHISPTADLDSARKRPT-------------HRTL-CPPPE------ 138
            :::.|.|.|:   ::.|....::....:.:.|.||.             .||. ...||      
Mouse    39 KERPQDVDQR---ESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWA 100

  Fly   139 --LMELSDSESQGGVETGGRREGATGRSAPDLEDTEPLYETENEFELKEVIKEGHDKADPSQFEL 201
              :..::|...:...||...|.|    |..|....|         |::..:.:...:...::||.
Mouse   101 TAIQTVADGLKRQEEETMDFRSG----SPSDNSGAE---------EMEVSLAKPKHRVTMNEFEY 152

  Fly   202 LRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRST-NERKILADVGHAFIVRLH 265
            |::||:|:||||.||::   |..|..||||:|||..:..||.|..| .|.::|.:..|.|:..|.
Mouse   153 LKLLGKGTFGKVILVKE---KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214

  Fly   266 YAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHT-LGIIYRDLKPEN 329
            |:|||..:|..::::..||:||..||:|.:|:|:..:||.||:..|:::||: ..::|||||.||
Mouse   215 YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLEN 279

  Fly   330 ILLDEHGHIALTDFGLSKQPL-DGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLT 393
            ::||:.|||.:|||||.|:.: ||:...:||||.||:|||::....:..|.|||..||:||||:.
Mouse   280 LMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC 344

  Fly   394 GNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFA 458
            |.|||:.|..::....||..::..|..|.|||:|||..|.|::|..|||.|::...:|..|.|||
Mouse   345 GRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFA 409

  Fly   459 TIDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTSKSPRDSPGGPI--SASAHEIFRGFSFVAPV 520
            .|.|..:..|::.|||.|.| |..|..|||.|:|::....:|...:  .:..|.           
Mouse   410 NIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQVLLLSQWHS----------- 463

  Fly   521 LLEGQCAGSN--MC-STSASP 538
            |..|..|||:  :| :.|.||
Mouse   464 LRPGAAAGSSTLLCIAESRSP 484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
S6kIINP_001259779.1 S_TKc 199..457 CDD:214567 114/260 (44%)
STKc_RSK_N 203..517 CDD:270734 131/319 (41%)
STKc_RSK_C 567..883 CDD:270993
S_TKc 568..834 CDD:214567
Akt1NP_001159366.1 PH_PKB 4..111 CDD:269947 12/74 (16%)
PH 6..104 CDD:278594 11/67 (16%)
Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250 14..19
Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250 23..25
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..137 8/35 (23%)
Pkinase 150..408 CDD:278497 114/260 (44%)
STKc_PKB 154..466 CDD:270723 132/325 (41%)
Inhibitor binding. /evidence=ECO:0000250 228..230 0/1 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R469
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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