DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and Rps6ka3

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_683747.1	Gene:	Rps6ka3 / 110651	MGIID:	104557	Length:	740	Species:	Mus musculus

Alignment Length:	785	Identity:	446/785 - (56%)
Similarity:	547/785 - (69%)	Gaps:	78/785 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 LMELSDSESQGGVETGGRREGATGRSAPDLEDTEPLYETE-----NEFELKEV-----IKEGHDK 193
            |.:|:|...:..||:.. .....|:...|    ||:.|.|     .|..:||:     :||||:|
Mouse     3 LAQLADPWQKMAVESPS-DSAENGQQIMD----EPMGEEEINPQTEEGSIKEIAITHHVKEGHEK 62

  Fly   194 ADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGH 258
            |||||||||:|||:|||||||||:||.|.||..||||||||||||||:||||:..||.||.:|.|
Mouse    63 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNH 127

  Fly   259 AFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYR 323
            .|||:|||||||.||||||||||||||||||||||||||||||||||||||||::|||:||||||
Mouse   128 PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYR 192

  Fly   324 DLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVL 387
            |||||||||||.|||.||||||||:.:| ..|.|||||||||||||:|||:||..:|||||||||
Mouse   193 DLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVL 257

  Fly   388 MYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIK 452
            |:|||||.|||.|:.|:|||..||::|||||:.||||||||||.||||||.||||||..|:.:||
Mouse   258 MFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIK 322

  Fly   453 AHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSF 516
            .|.||:||||.:|.|:::.|||.||..| :|.||||.|:|:|:|:||||.|.||:||::||||||
Mouse   323 RHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSF 387

  Fly   517 VAPVLLEGQCAGSNMCSTSASP------LHSIAPIPAAPVGAPRTLPGVLPGN---FHAEYNLLQ 572
            ||            :.|...|.      :|||..              .|..|   |...|.:.:
Mouse   388 VA------------ITSDDESQAMQTVGVHSIVQ--------------QLHRNSIQFTDGYEVKE 426

  Fly   573 ELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSV 637
            ::|.|::|||:.|.|:|:...:|||:|:|         :..|..||:||:||||.||||:||..|
Mouse   427 DIGVGSYSVCKRCIHKATNMEFAVKIIDK---------SKRDPTEEIEILLRYGQHPNIITLKDV 482

  Fly   638 YEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIY 702
            |:|....|:|.||:|||||||:||......|.||||||.||...|.|||..|||||||||||::|
Mouse   483 YDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILY 547

  Fly   703 ASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIML 767
            ......||::::||.||||||||:|||||||||||||||||||||||||.||||||||||||.||
Mouse   548 VDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTML 612

  Fly   768 SGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHD 832
            :|.||||:.|:|:|:.||.|||||:...:...|..:|..||:|:.:|||:.|..|.|||.:|.|.
Mouse   613 TGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHP 677

  Fly   833 WLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALRGAVDATFRAIAIPQAANVGPVELSM 897
            |:    ....||.:|      ||:    :|...|:   ::||:.||:.|:...|:..:.||..|.
Mouse   678 WI----VHWDQLPQY------QLN----RQDAPHL---VKGAMAATYSALNRNQSPVLEPVGRST 725

  Fly   898 LAKRR 902
            ||:||
Mouse   726 LAQRR 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	202/258 (78%)
		STKc_RSK_N	203..517	CDD:270734	235/315 (75%)
		STKc_RSK_C	567..883	CDD:270993	164/315 (52%)
		S_TKc	568..834	CDD:214567	151/265 (57%)
Rps6ka3	NP_683747.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		11/42 (26%)
		STKc_RSK_N	72..388	CDD:270734	235/315 (75%)
		STKc_RSK2_C	402..740	CDD:271078	178/369 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	396	1.000	Domainoid score	I752
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37940
Inparanoid	1	1.050	824	1.000	Inparanoid score	I464
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55819
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		otm43821
orthoMCL	1	0.900	-	-		OOG6_101790
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.810