Protein Alignment S6kII and SGK2

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_057360.3
• Gene: SGK2 / 10110
• HGNCID: 13900
• Length: 367
• Species: Homo sapiens
• Alignment Length: 335
• Identity: 151/335 - (45%)
• Similarity: 211/335 - (62%)
• Gaps: 14/335 - (4%)

  Fly   194 ADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVL-KKATLKVKDRVRSTNERKI-LADV 256
            |.|:.|:.|:|:|:|::|||.|.::   |..|..||:||| ||:.||.|::.....||.: |.:|
Human    30 AQPTDFDFLKVIGKGNYGKVLLAKR---KSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNV 91

  Fly   257 GHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGII 321
            .|.|:|.|.|:||||.|||.:||::.||:||..|.:|..|.|...:||.||:|.|:.:||:|.||
Human    92 RHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNII 156

  Fly   322 YRDLKPENILLDEHGHIALTDFGLSKQPLDGSKTYS-FCGTVEYMAPEIVNRKGHDFAADWWSFG 385
            ||||||||||||..||:.||||||.|:.::...|.| ||||.||:|||::.::.:|.|.|||..|
Human   157 YRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLG 221

  Fly   386 VLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILD 450
            .::||||.|..||:.|...:....||...|.:|...:..|..||::|..::.:.|||:.|. .|:
Human   222 AVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKAD-FLE 285

  Fly   451 IKAHCFFATIDWVRLERKQVRPPFIPAVSRD-DAFYFDVEYT----SKSPRDSPGGPISAS-AHE 509
            ||.|.||:.|:|..|..|::.|||.|.|:.. |..:||.|:|    |||...:|....|:| |..
Human   286 IKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASS 350

  Fly   510 IFRGFSFVAP 519
            .|.|||: ||
Human   351 AFLGFSY-AP 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	145/322 (45%)
		STKc_RSK_C	567..883	CDD:270993
SGK2	NP_057360.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		STKc_SGK2	39..359	CDD:270754	145/324 (45%)
		Nuclear localization signal. /evidence=ECO:0000250	68..78		5/9 (56%)