Protein Alignment S6kII and rps6ka3

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: XP_031752603.1
• Gene: rps6ka3 / 100496161
• XenbaseID: XB-GENE-480947
• Length: 737
• Species: Xenopus tropicalis
• Alignment Length: 770
• Identity: 443/770 - (57%)
• Similarity: 547/770 - (71%)
• Gaps: 51/770 - (6%)

  Fly   139 LMELSDSESQGGVETGGRREGA--TGRSAPDLEDTEPLYETE-NEFELKEVIKEGHDKADPSQFE 200
            |.:|:|...:..|:..|...|.  ...|..| ||.|...|.. ||..:...:||||:||||||||
 Frog     3 LAQLADPWQKVPVQKVGSENGQQFADESMCD-EDNENNDEGNINEIAITHHVKEGHEKADPSQFE 66

  Fly   201 LLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLH 265
            ||:|||:||||||||||||.|.|||.||||||||||||||:||||:..||.||.:|.|.|||:||
 Frog    67 LLKVLGQGSFGKVFLVRKISGTDAGQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLH 131

  Fly   266 YAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENI 330
            |||||.|||||||||||||||||||||||||||||||:||||||||::|||:|||||||||||||
 Frog   132 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKYYLAELALALDHLHSLGIIYRDLKPENI 196

  Fly   331 LLDEHGHIALTDFGLSKQPLD-GSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTG 394
            ||||.|||.||||||||:.:| ..|.|||||||||||||:|||:||..:||||||||||:|||||
 Frog   197 LLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG 261

  Fly   395 NLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFAT 459
            .|||.|:.|:|||..||::|||||:.|:||||||||.||||||.||||||..|:.:||.|.||||
 Frog   262 TLPFQGKDRKETMTMILKAKLGMPQFLTPEAQSLLRMLFKRNPTNRLGAGPDGVEEIKRHPFFAT 326

  Fly   460 IDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLE 523
            |||.:|.|::.:|||.||. ..:|.||||.|:|:|:|:||||.|.||:||::|||||||| :..|
 Frog   327 IDWNKLYRRENQPPFKPATGGPEDTFYFDPEFTAKTPKDSPGIPASANAHQLFRGFSFVA-ITSE 390

  Fly   524 GQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPGVLPGNFHAEYNLLQELGRGTFSVCRLCEHR 588
            .:    |....:.. :|:|.|:....:            .|...|.|.:::|.|::|:|:.|.|:
 Frog   391 DE----NQAMQTVG-VHAIVPLHRNSI------------QFTDGYELKEDIGVGSYSICKRCIHK 438

  Fly   589 ASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKG 653
            .:...||||:|:|         :..|..||:||:||||.||||:||..||:|....|||.||:||
 Frog   439 GTNMEYAVKIIDK---------SKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYLVTELMKG 494

  Fly   654 GELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLG 718
            |||||:||......|.||||||.||...|.|||...||||||||||::|......||::::||.|
 Frog   495 GELLDKILRQKFFSEREASAVLHTITKTVEYLHSQWVVHRDLKPSNILYVDESGNPESIRICDFG 559

  Fly   719 FAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDV 783
            |||||||:|||||||||||||||||||||||||.||||||||||||.||:|.||||:.|:|:|:.
 Frog   560 FAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEE 624

  Fly   784 ILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYA 848
            ||.|||||:...:...|..:|..||:|:.:|||:.|..|.|||::|:|.|:       |...:
 Frog   625 ILARIGSGKFSLSGGYWNSVSDIAKDLVSKMLHVDPHQRLTAAQVLKHPWI-------VHCDQ-- 680

  Fly   849 VAPGSQLSLGAQQQQQNHISMALRGAVDATFRAIAI-PQAANVGPVELSMLAKRR 902
             .|..||:    :|...|:   ::||:.||:.|:.: |.:..:.||..|.||:||
 Frog   681 -LPQFQLN----RQDAPHL---VKGAMAATYSALNLNPLSPVLEPVGRSTLAQRR 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	235/315 (75%)
		STKc_RSK_C	567..883	CDD:270993	163/315 (52%)
rps6ka3	XP_031752603.1	STKc_RSK_N	69..385	CDD:270734	235/315 (75%)
		STKc_RSK2_C	399..737	CDD:271078	175/368 (48%)