DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and rps6ka3

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_031752603.1	Gene:	rps6ka3 / 100496161	XenbaseID:	XB-GENE-480947	Length:	737	Species:	Xenopus tropicalis

Alignment Length:	770	Identity:	443/770 - (57%)
Similarity:	547/770 - (71%)	Gaps:	51/770 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 LMELSDSESQGGVETGGRREGA--TGRSAPDLEDTEPLYETE-NEFELKEVIKEGHDKADPSQFE 200
            |.:|:|...:..|:..|...|.  ...|..| ||.|...|.. ||..:...:||||:||||||||
Frog     3 LAQLADPWQKVPVQKVGSENGQQFADESMCD-EDNENNDEGNINEIAITHHVKEGHEKADPSQFE 66

  Fly   201 LLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLH 265
            ||:|||:||||||||||||.|.|||.||||||||||||||:||||:..||.||.:|.|.|||:||
Frog    67 LLKVLGQGSFGKVFLVRKISGTDAGQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLH 131

  Fly   266 YAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENI 330
            |||||.|||||||||||||||||||||||||||||||:||||||||::|||:|||||||||||||
Frog   132 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKYYLAELALALDHLHSLGIIYRDLKPENI 196

  Fly   331 LLDEHGHIALTDFGLSKQPLD-GSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTG 394
            ||||.|||.||||||||:.:| ..|.|||||||||||||:|||:||..:||||||||||:|||||
Frog   197 LLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG 261

  Fly   395 NLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFAT 459
            .|||.|:.|:|||..||::|||||:.|:||||||||.||||||.||||||..|:.:||.|.||||
Frog   262 TLPFQGKDRKETMTMILKAKLGMPQFLTPEAQSLLRMLFKRNPTNRLGAGPDGVEEIKRHPFFAT 326

  Fly   460 IDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLE 523
            |||.:|.|::.:|||.||. ..:|.||||.|:|:|:|:||||.|.||:||::|||||||| :..|
Frog   327 IDWNKLYRRENQPPFKPATGGPEDTFYFDPEFTAKTPKDSPGIPASANAHQLFRGFSFVA-ITSE 390

  Fly   524 GQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPGVLPGNFHAEYNLLQELGRGTFSVCRLCEHR 588
            .:    |....:.. :|:|.|:....:            .|...|.|.:::|.|::|:|:.|.|:
Frog   391 DE----NQAMQTVG-VHAIVPLHRNSI------------QFTDGYELKEDIGVGSYSICKRCIHK 438

  Fly   589 ASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKG 653
            .:...||||:|:|         :..|..||:||:||||.||||:||..||:|....|||.||:||
Frog   439 GTNMEYAVKIIDK---------SKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYLVTELMKG 494

  Fly   654 GELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLG 718
            |||||:||......|.||||||.||...|.|||...||||||||||::|......||::::||.|
Frog   495 GELLDKILRQKFFSEREASAVLHTITKTVEYLHSQWVVHRDLKPSNILYVDESGNPESIRICDFG 559

  Fly   719 FAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDV 783
            |||||||:|||||||||||||||||||||||||.||||||||||||.||:|.||||:.|:|:|:.
Frog   560 FAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEE 624

  Fly   784 ILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYA 848
            ||.|||||:...:...|..:|..||:|:.:|||:.|..|.|||::|:|.|:       |...:
Frog   625 ILARIGSGKFSLSGGYWNSVSDIAKDLVSKMLHVDPHQRLTAAQVLKHPWI-------VHCDQ-- 680

  Fly   849 VAPGSQLSLGAQQQQQNHISMALRGAVDATFRAIAI-PQAANVGPVELSMLAKRR 902
             .|..||:    :|...|:   ::||:.||:.|:.: |.:..:.||..|.||:||
Frog   681 -LPQFQLN----RQDAPHL---VKGAMAATYSALNLNPLSPVLEPVGRSTLAQRR 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	202/258 (78%)
		STKc_RSK_N	203..517	CDD:270734	235/315 (75%)
		STKc_RSK_C	567..883	CDD:270993	163/315 (52%)
		S_TKc	568..834	CDD:214567	151/265 (57%)
rps6ka3	XP_031752603.1	STKc_RSK_N	69..385	CDD:270734	235/315 (75%)
rps6ka3	XP_031752603.1	STKc_RSK2_C	399..737	CDD:271078	175/368 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	401	1.000	Domainoid score	I721
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37940
Inparanoid	1	1.050	821	1.000	Inparanoid score	I462
OMA	1	1.010	-	-		QHG55819
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		otm48991
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.980