DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and rps6ka2

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_002942396.3	Gene:	rps6ka2 / 100495717	XenbaseID:	XB-GENE-487242	Length:	732	Species:	Xenopus tropicalis

Alignment Length:	741	Identity:	426/741 - (57%)
Similarity:	525/741 - (70%)	Gaps:	56/741 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 YETE---NEFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKA 236
            ||.|   .|.::...:|||.:||:|||||||:|||:||:||||||||:.|.|:..|||||||:||
Frog    33 YEDEGIVKEIDISHHVKEGFEKAEPSQFELLKVLGQGSYGKVFLVRKVKGSDSEQLYAMKVLRKA 97

  Fly   237 TLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDV 301
            ||||:|||||..||.|||:|.|.|||:|||||||.||||||||||||||||:|||||||||||||
Frog    98 TLKVRDRVRSRMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFSRLSKEVMFTEEDV 162

  Fly   302 KFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLDGSK-TYSFCGTVEYM 365
            ||||||||||::|||:.||||||||||||||||.|||.:|||||||:.:|..| .||||||:|||
Frog   163 KFYLAELALALDHLHSFGIIYRDLKPENILLDEEGHIKITDFGLSKESIDHDKRAYSFCGTIEYM 227

  Fly   366 APEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLR 430
            |||:|||:||..:||||||||||:|||||:|||.|:.|:|||..||::|||||:.||.|||.|||
Frog   228 APEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSSEAQCLLR 292

  Fly   431 ALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFYFDVEYTSKS 494
            |||||||.||||||..|:.:||.|.||:||||..|.||:::|||.|||.| :|.|:||.|:||::
Frog   293 ALFKRNPCNRLGAGLDGVEEIKRHSFFSTIDWNNLYRKEIKPPFKPAVGRPEDTFHFDPEFTSRT 357

  Fly   495 PRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPGV 559
            |.||||.|.||:.|.:|||||:|||.|      ..|...:..|.:|.|..              .
Frog   358 PTDSPGIPPSANTHNLFRGFSYVAPNL------DYNPHDSYNSSVHPIVQ--------------Q 402

  Fly   560 LPGN---FHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEI 621
            |.|:   |...|.:.::||.||:::|:.|.|:|:...:|||:|:|         :..|..||:||
Frog   403 LHGSNIQFSDGYMIKEDLGIGTYAICKRCVHKATNTEFAVKIIDK---------SKRDPSEEIEI 458

  Fly   622 MLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLH 686
            :||||.||||:||..||:|....||||||:.||||||:||......|.||||||..|.....|||
Frog   459 LLRYGQHPNIITLKDVYDDGKYVYLVMELMMGGELLDKILRQKCFSEREASAVLCVITKTAEYLH 523

  Fly   687 EHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYD 751
            ..|||||||||||::|......||::::||.||||||||:|||||||||||||||||||||||||
Frog   524 TQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYD 588

  Fly   752 LACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLH 816
            .||||||||:|||.||:|.||||:.|.|:|:.||.|||||:...|...|..||..||:::.:|||
Frog   589 AACDIWSLGILLYTMLAGFTPFANGPEDTPEEILARIGSGKYALTGGNWDSISDAAKDIVAKMLH 653

  Fly   817 IVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALRGAVDATFRA 881
            :.|..|.||.::|.|.|:..:        ||.          :|.|...|....::.|::||:.|
Frog   654 VDPHQRLTATQVLHHPWIVNR--------EYL----------SQNQLSRHDYRLVKAAMEATYFA 700

  Fly   882 I-AIPQAANVGPVELSMLAKRRAKDR 906
            : ..|.|..:.||..|.|||||..:|
Frog   701 LNHRPLAPKLEPVNSSTLAKRRGMNR 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	196/258 (76%)
		STKc_RSK_N	203..517	CDD:270734	229/315 (73%)
		STKc_RSK_C	567..883	CDD:270993	159/316 (50%)
		S_TKc	568..834	CDD:214567	149/265 (56%)
rps6ka2	XP_002942396.3	STKc_RSK_N	64..380	CDD:270734	229/315 (73%)
rps6ka2	XP_002942396.3	STKc_RSK3_C	410..702	CDD:271080	160/318 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	401	1.000	Domainoid score	I721
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	821	1.000	Inparanoid score	I462
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		otm48991
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060