DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and rps6ka5

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_002933270.1	Gene:	rps6ka5 / 100489041	XenbaseID:	XB-GENE-950590	Length:	784	Species:	Xenopus tropicalis

Alignment Length:	761	Identity:	309/761 - (40%)
Similarity:	426/761 - (55%)	Gaps:	87/761 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 ELKEVIKEGH-DKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATL--KVKDR 243
            ||:.....|| :|.....||||:|||.|::|||||||||.|.|:|.|||||||||||:  |.|..
Frog    16 ELRTANLTGHTEKVGLENFELLKVLGTGAYGKVFLVRKISGHDSGKLYAMKVLKKATIIQKAKTA 80

  Fly   244 VRSTNERKILADVGHA-FIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 307
            ..:..||::|..:..: |:|.|||||||..||:||||::.||:|||.||:...|||.:|..|:.|
Frog    81 EHTRTERQVLEHIRQSPFLVTLHYAFQTDTKLHLILDYINGGELFTHLSQREKFTENEVLVYIGE 145

  Fly   308 LALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL--DGSKTYSFCGTVEYMAPEIV 370
            :.||:.|||.|||||||:|.||||||..||:.||||||||:.|  :..:.||||||:||||||||
Frog   146 IVLALEHLHKLGIIYRDIKLENILLDSSGHVVLTDFGLSKEFLSDENERAYSFCGTIEYMAPEIV 210

  Fly   371 --NRKGHDFAADWWSFGVLMYEMLTGNLPF----HGQTRQETMNQILRSKLGMPENLSPEAQSLL 429
              ...|||.|.||||.||||||:|||..||    ...::.|...:||:|:...|:.:|...:.::
Frog   211 KGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSEAVKDII 275

  Fly   430 RALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSRD-DAFYFDVEYTSK 493
            |.|..::|:.|||.|..|..:||.|.||.:.:|..|..|::..||.|.:..: |...|..|:|..
Frog   276 RCLLLKDPKKRLGCGPDGCDEIKKHPFFKSFNWDDLAAKKIPAPFKPIIKDELDVGNFAEEFTEM 340

  Fly   494 SPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPG 558
            .|..||.. :..:|..||:|:|||||.:|             ..|..:||......:|..|  ||
Frog   341 DPTYSPAA-LPMNADRIFQGYSFVAPSIL-------------FRPNAAIADPLQYHLGIER--PG 389

  Fly   559 VL-----------PGNFHAEYNLLQE-LGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTST 611
            ..           |...|.|.:|..: ||.|:||:||.|.|:.:.:.||||::.|        ..
Frog   390 TTSIARSAMMKDSPFYQHYELDLKDKPLGEGSFSICRKCLHKKTNQEYAVKIVSK--------RM 446

  Fly   612 SADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLR 676
            .::...|:..|....:|||||.|..|:.|....:|||||||||||.:||.......|:|||.::|
Frog   447 ESNTQREIAAMKLCQSHPNIVKLCDVFHDQLHTFLVMELLKGGELFERIKKKKLFSETEASHIMR 511

  Fly   677 TIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVA 741
            .:.|||:::|:.|||||||||.|.::.......| :|:.|.|||:....||..|.|||:|.::.|
Frog   512 RLVSAVSHMHDVGVVHRDLKPENFLFTDESDNSE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAA 575

  Fly   742 PEVLKRQGYDLACDIWSLGVLLYIMLSGRTPF----ASTPNDSPDVILKRIGSGQIDFTSSRWAL 802
            ||:|...|||.:||:|||||:||.||||:.||    .:....|.:.|:|:|..|........|..
Frog   576 PELLNENGYDESCDLWSLGVILYTMLSGQVPFQCHGKTLQCTSAEDIMKKIKQGDFSCEGEAWTN 640

  Fly   803 ISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQLS---------LG 858
            :|..||:|::.:|.:.|..|...:.:..::||::               |||||         ||
Frog   641 VSQEAKDLIQGLLTVDPNKRIKMSTLRYNEWLQD---------------GSQLSSNPLMTPDILG 690

  Fly   859 AQQQQQNHISMALRGAVDATFRAI--AIPQAANVGPVELSMLAKRR 902
            :       ...::...|.|||.|.  ...:...:..|:.:.|||||
Frog   691 S-------AGASVHTHVKATFHAFNKYKREGFRLQNVDKAPLAKRR 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	144/268 (54%)
		STKc_RSK_N	203..517	CDD:270734	160/325 (49%)
		STKc_RSK_C	567..883	CDD:270993	120/331 (36%)
		S_TKc	568..834	CDD:214567	105/270 (39%)
rps6ka5	XP_002933270.1	STKc_MSK1_N	33..322	CDD:270764	151/288 (52%)
		S_TK_X	304..364	CDD:214529	19/60 (32%)
		STKc_MSK1_C	403..712	CDD:271081	122/339 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010