Protein Alignment S6kII and rps6ka4

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: XP_002941501.1
• Gene: rps6ka4 / 100486973
• XenbaseID: XB-GENE-5759516
• Length: 766
• Species: Xenopus tropicalis
• Alignment Length: 763
• Identity: 318/763 - (41%)
• Similarity: 440/763 - (57%)
• Gaps: 73/763 - (9%)

  Fly   166 PD-LEDTEPLYE--TENEFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTL 227
            || :|...|::.  |.||           |:.....||||::||.|::||||||||:.|.||..|
 Frog     4 PDRIETRSPIHVNLTGNE-----------DRVAMKDFELLKILGTGAYGKVFLVRKVTGPDASRL 57

  Fly   228 YAMKVLKKATLKVKDRV--RSTNERKILADVGHA-FIVRLHYAFQTPGKLYLILDFLRGGDLFTR 289
            ||||||:|..|..|::.  .:..||.:|..|..: |:|.|||||||..||:||||::.||:|||.
 Frog    58 YAMKVLQKCALVKKEKTVEHTKTERNVLEHVRESPFLVTLHYAFQTDAKLHLILDYVSGGELFTH 122

  Fly   290 LSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL--DG 352
            |.:...|:|:.|:||..|:.||:.|||.|||:|||:|.||||||..||:.||||||||:.|  :.
 Frog   123 LYQRDNFSEDAVRFYSGEVILALEHLHKLGIVYRDIKLENILLDSEGHVILTDFGLSKEFLSEEE 187

  Fly   353 SKTYSFCGTVEYMAPEIV-NRKGHDFAADWWSFGVLMYEMLTGNLPF--HGQ--TRQETMNQILR 412
            .:|||||||.|||||||: .:.||....||||.|:|:||:|||..||  .|:  |:.|...:||:
 Frog   188 ERTYSFCGTTEYMAPEIIRGQGGHGKIVDWWSLGILIYELLTGASPFTLEGEKNTQSEVSRRILK 252

  Fly   413 SKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPA 477
            ....:|..||.||:.||:.|.:::|:.||||.  |...||.|.|:..:||..|...:|.|||.|:
 Frog   253 MDPSIPSFLSLEARDLLQKLLRKDPKKRLGAA--GASQIKEHPFYKDLDWEALSLHKVNPPFRPS 315

  Fly   478 VSRD-DAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCA-GSNMCSTSA-SPL 539
            :..: |...|..|:|:..|..||.|...:.| .:|:|:||:||.:|.|:.| .::|.:.|| .|.
 Frog   316 IRNETDVSNFAEEFTNLDPVYSPAGTPPSGA-PVFQGYSFIAPSVLFGRNAVMTDMAAPSADKPG 379

  Fly   540 HSIAPIPAAPVGAPRTLPGVLPGNFHAEYNL-LQE--LGRGTFSVCRLCEHRASKKHYAVKVIEK 601
            .....:.||...:|          |...|.: |:|  ||.|::|:||.|:||.::|.||||:|
 Frog   380 SPTLALSAAMKDSP----------FFQLYEIDLEEPALGSGSYSLCRKCQHRQTQKEYAVKII-- 432

  Fly   602 AAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQM 666
                  |....|:...||..:.....|||||||:.|..|...:|||||||.||||||||......
 Frog   433 ------SRRMEANTQREVAALRLCQGHPNIVTLHEVLHDQYHSYLVMELLDGGELLDRIKKQACF 491

  Fly   667 CESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLM 731
            .|.|||:::|::.|||:::|..|||||||||.|::.:|..:. ..||:.|.|||:.....:..|.
 Frog   492 SEVEASSLMRSLVSAVSHMHSVGVVHRDLKPENLLLSSPGEN-AVLKVIDFGFARLRPPGSRPLH 555

  Fly   732 TPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDV----ILKRIGSGQ 792
            |||:|.::.|||:...||||..||:|:|||:||.||||:.||......||..    |:::|..|.
 Frog   556 TPCFTLHYAAPELFSNQGYDELCDLWTLGVILYTMLSGQVPFQVKRGKSPHTRAADIIQKIKKGD 620

  Fly   793 IDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEY-AVAPGSQLS 856
            .......|..:|..||||:|.:|.:.|..|.:.:.:.|.:||    .||..|:.. .:.|....|
 Frog   621 FSMEGKCWEHVSEEAKELVRGLLIVDPTCRLSLSELQESEWL----CGGRPLSSTPLMTPDVLES 681

  Fly   857 LGAQQQQQNHISMALRGAVDATFRAIAIPQAANV--GPVELSMLAKRR 902
            .|          :|.:..|||||.|....:...|  ..|:.:.|||||
 Frog   682 SG----------LATKNCVDATFMAFNRGKREGVFLKSVDNAPLAKRR 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	156/324 (48%)
		STKc_RSK_C	567..883	CDD:270993	129/323 (40%)
rps6ka4	XP_002941501.1	STKc_MSK2_N	28..357	CDD:270765	161/331 (49%)
		STKc_MSK2_C	394..702	CDD:271082	130/330 (39%)