DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6kII and akt2

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001116936.1	Gene:	akt2 / 100144709	XenbaseID:	XB-GENE-484168	Length:	485	Species:	Xenopus tropicalis

Alignment Length:	396	Identity:	148/396 - (37%)
Similarity:	230/396 - (58%)	Gaps:	29/396 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 VETGGRRE-----------GATGRSAPDLED--TEPLYETENEFELKE----VIKEGHDKADPSQ 198
            |:|...||           |...:.|.|.|:  .|..|.:.::....|    .:.:|..|...:.
Frog    91 VDTPEEREEWIIAIQTVANGLKNQVAEDEEEEAMEVKYGSPSDVSSAEQMDVAMSKGRPKVTMND 155

  Fly   199 FELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRST-NERKILADVGHAFIV 262
            |:.|::||:|:||||.|||:   |.:|..||||:|:|..:..||.|..| .|.::|.:..|.|:.
Frog   156 FDYLKLLGKGTFGKVILVRE---KSSGRYYAMKILRKEVIIAKDEVAHTLTESRVLQNTKHPFLT 217

  Fly   263 RLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKP 327
            .|.|||||..:|..::::..||:||..||:|.:|||:..:||.||:..|:.:||:..::|||:|.
Frog   218 ALKYAFQTSDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRNVVYRDIKL 282

  Fly   328 ENILLDEHGHIALTDFGLSKQPL-DGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEM 391
            ||::||:.||:.:|||||.|:.: ||:...:||||.||:|||::....:..|.|||..||:||||
Frog   283 ENLMLDKDGHVKITDFGLCKEGITDGATMRTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 347

  Fly   392 LTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCF 456
            :.|.|||:.|..:.....||..::..|..|||||:|||..|.|::|:.|||.|.....::.:|.|
Frog   348 MCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPNDAQEVMSHRF 412

  Fly   457 FATIDWVRLERKQVRPPFIPAVSRD-DAFYFDVEYTSKSPRDSPG------GPISASAHEIFRGF 514
            ||:|:|..:..:::.|||.|.|:.: |..|||.|:|::|...:|.      ..:.:.....|..|
Frog   413 FASINWQDVTERKLTPPFKPQVTSEIDTRYFDDEFTAQSITLTPPDRYDNLDALESDQRPHFPQF 477

  Fly   515 SFVAPV 520
            |:.|.:
Frog   478 SYSASI 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	113/259 (44%)
		STKc_RSK_N	203..517	CDD:270734	132/322 (41%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
akt2	NP_001116936.1	PH_PKB	4..112	CDD:269947	5/20 (25%)
akt2	NP_001116936.1	STKc_PKB_beta	160..482	CDD:173686	132/324 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030