DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and rps6ka1

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_012811865.1	Gene:	rps6ka1 / 100144704	XenbaseID:	XB-GENE-479496	Length:	750	Species:	Xenopus tropicalis

Alignment Length:	783	Identity:	441/783 - (56%)
Similarity:	551/783 - (70%)	Gaps:	65/783 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 PELMELSDSESQGGVETGGRREGA-TGRSAPDLEDTEP----LYETE---NEFELKEVIKEGHDK 193
            || :|:...|::.| ..||...|. ..:..|::...|.    ||:.|   .|..:...:|||.:|
Frog    11 PE-VEVVHEETENG-HVGGEESGRHISKVKPEISWIEREFFLLYKDEVVVKEIPITHHVKEGSEK 73

  Fly   194 ADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGH 258
            ||.|.|.||:|||:||||||||||||...||..||||||||||||||:||||:..||.|||||.|
Frog    74 ADQSHFVLLKVLGQGSFGKVFLVRKITPPDANQLYAMKVLKKATLKVRDRVRTKMERDILADVHH 138

  Fly   259 AFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYR 323
            .|:|||||||||.|||||||||||||||||||||||||||||||||||||||.::|||:||||||
Frog   139 PFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYR 203

  Fly   324 DLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVL 387
            |||||||||||.|||.||||||||:.:| ..|.|||||||||||||:|||:||..:|||||:|||
Frog   204 DLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVL 268

  Fly   388 MYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIK 452
            |:|||||:|||.|:.|:|||..||::|||||:.||.|||.|||:||||||.||||:|.:|..:||
Frog   269 MFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSNEAQGLLRSLFKRNPTNRLGSGVEGAEEIK 333

  Fly   453 AHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSF 516
            .|.||:||||.:|.|:.:.|||.|||:: ||.:|||.|:||::|:||||.|.||.||::||||||
Frog   334 RHPFFSTIDWNKLYRRDMSPPFKPAVTQPDDTYYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSF 398

  Fly   517 VAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRT-LPGVLPGNFHAEYNLLQELGRGTFS 580
            |||||:|     .:...||:.|:.|:          |:| ...||   |...|.:.:.:|.|::|
Frog   399 VAPVLVE-----EDAKKTSSPPVLSV----------PKTHSKNVL---FTDVYTVRETIGVGSYS 445

  Fly   581 VCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAY 645
            ||:.|.|:.:...||||||:|         |..|..||:||:.|||.||||:||..|||:..|.|
Frog   446 VCKRCVHKGTNMEYAVKVIDK---------TKRDPSEEIEILRRYGQHPNIITLKDVYEEGNSIY 501

  Fly   646 LVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPE 710
            ||.||::|||||||||......|.||:.||.|:...|.|||..|||||||||||::|......||
Frog   502 LVTELMRGGELLDRILRQKFFSEREANLVLLTVCKTVEYLHSQGVVHRDLKPSNILYVDESGNPE 566

  Fly   711 TLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFAS 775
            ::::||.||||||||:|||||||||||||||||||||||||..|||||||:|:|.||:|.||||:
Frog   567 SIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILVYTMLAGYTPFAN 631

  Fly   776 TPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAG 840
            .|.|:|:.||.|||||:.......|..:|..||:|:.:|||:.|..|.||.::|:|:|
Frog   632 GPGDTPEEILARIGSGKFTLRGGNWNTVSDSAKDLVSRMLHVDPHRRLTAKQVLQHEW------- 689

  Fly   841 GVQLTEYAVAPGSQLSLGAQQQQQNHISMALRGAVDATFRAI----AIPQAANVGPVELSMLAKR 901
               :|...:.|.|||:     :|..|:   ::||:.||:.|:    ..||   :.|::.|:||:|
Frog   690 ---ITNRDLLPQSQLN-----RQDVHL---VKGAMAATYSALNSSKPTPQ---LQPIKSSILAQR 740

  Fly   902 RAK 904
            |.|
Frog   741 RVK 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	198/258 (77%)
		STKc_RSK_N	203..517	CDD:270734	232/315 (74%)
		STKc_RSK_C	567..883	CDD:270993	160/319 (50%)
		S_TKc	568..834	CDD:214567	147/265 (55%)
rps6ka1	XP_012811865.1	S_TKc	79..338	CDD:214567	198/258 (77%)
		STKc_RSK_N	83..399	CDD:270734	232/315 (74%)
		PKc_like	431..721	CDD:304357	160/316 (51%)
		Pkinase	433..690	CDD:278497	148/275 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	401	1.000	Domainoid score	I721
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	821	1.000	Inparanoid score	I462
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		otm48991
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060