DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and rps6ka3b

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_009295647.1	Gene:	rps6ka3b / 100009657	ZFINID:	ZDB-GENE-070209-74	Length:	739	Species:	Danio rerio

Alignment Length:	768	Identity:	443/768 - (57%)
Similarity:	538/768 - (70%)	Gaps:	71/768 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 REGATGRSAPDLEDTEP-------LYETEN-----EFELKEV-----IKEGHDKADPSQFELLRV 204
            |:.|.|.:|   .:|||       :.|.||     |..:||:     :|||.:||||.||||.:|
Zfish    11 RKMAIGSAA---SETEPHHVLEDSMGEDENLSCQEEVSVKEINITHLVKEGSEKADPQQFELRKV 72

  Fly   205 LGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQ 269
            ||:|||||||||:|..|.|||.||||||||||||||:|:||:..||.||.:|.|.|||:||||||
Zfish    73 LGQGSFGKVFLVKKTTGPDAGQLYAMKVLKKATLKVRDQVRTKMERDILVEVNHPFIVKLHYAFQ 137

  Fly   270 TPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDE 334
            |.||||||||||||||||||||||||||||||||||||||||::|||.|||||||||||||||||
Zfish   138 TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDE 202

  Fly   335 HGHIALTDFGLSKQPLD-GSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPF 398
            .|||.||||||||:.:| .:|.|||||||||||||:|||:||.::|||||:||||||||||.|||
Zfish   203 DGHIKLTDFGLSKESIDHENKAYSFCGTVEYMAPEVVNRRGHTYSADWWSYGVLMYEMLTGTLPF 267

  Fly   399 HGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWV 463
            .|:.|:|||..||::|||||:.||.|||||||:||||||.||||||..|:.:||.|.|:.:|||.
Zfish   268 QGKDRKETMTMILKAKLGMPQFLSSEAQSLLRSLFKRNPTNRLGAGPDGVEEIKRHPFYVSIDWN 332

  Fly   464 RLERKQVRPPFIPAVSR-DDAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVL-LEGQC 526
            :|.|::..|||.||..| ||.||||.|:|:|:|:||||.|.||:|:.:||||||||... .|.|.
Zfish   333 KLFRRESHPPFKPATGRPDDTFYFDPEFTAKTPKDSPGVPPSANANRLFRGFSFVAITSEEESQS 397

  Fly   527 AGSNMCSTSASPLHSIAPIPAAPVGAPRTLPGVLPGNFHAEYNLLQELGRGTFSVCRLCEHRASK 591
            ..||..|:....||             |.:     ..|...|.:.:::|.|.:|:|:.|..:::.
Zfish   398 LPSNSMSSIVQQLH-------------RNV-----SQFSDAYEVKEDIGIGAYSICKRCIQKSTM 444

  Fly   592 KHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGEL 656
            ..||||:|.||         ..|..|||||:||||.||||:||..||:|..:.|||.||||||||
Zfish   445 MEYAVKIISKA---------KRDPAEEVEILLRYGQHPNIITLKDVYDDGRTVYLVTELLKGGEL 500

  Fly   657 LDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAK 721
            ||:||......|.||.|||.||...|||||..|||||||||||::|......||::::||.||||
Zfish   501 LDKILRQKFFSEREACAVLHTITKTVAYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK 565

  Fly   722 QLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILK 786
            ||||:||||||||||||||||||||:||||.||||||||||||.||:|.||||:.|.|:|:.||.
Zfish   566 QLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVLLYTMLTGFTPFANGPEDTPEEILA 630

  Fly   787 RIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAP 851
            ||||||...|...|..:|..||:|:.:|||:.|..|.|||::|:|.|          :|.....|
Zfish   631 RIGSGQFSLTGGFWNSVSCQAKDLVSKMLHVDPHQRLTAAQVLKHPW----------ITHKDKLP 685

  Fly   852 GSQLSLGAQQQQQNHISMALRGAVDATFRAI--AIPQAANVGPVELSMLAKRR 902
            ..||:    :|...|:   ::||:.|||.|:  .||..  :.||..|:||:||
Zfish   686 NYQLN----RQDAPHL---VKGAMAATFSALNRNIPPV--LEPVGCSILAQRR 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	199/258 (77%)
		STKc_RSK_N	203..517	CDD:270734	231/315 (73%)
		STKc_RSK_C	567..883	CDD:270993	167/317 (53%)
		S_TKc	568..834	CDD:214567	154/265 (58%)
rps6ka3b	XP_009295647.1	S_TKc	67..325	CDD:214567	199/257 (77%)
		STKc_RSK_N	71..387	CDD:270734	231/315 (73%)
		PKc_like	403..739	CDD:304357	181/373 (49%)
		Pkinase	421..678	CDD:278497	155/275 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	398	1.000	Domainoid score	I709
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37940
Inparanoid	1	1.050	828	1.000	Inparanoid score	I444
OMA	1	1.010	-	-		QHG55819
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		otm24234
orthoMCL	1	0.900	-	-		OOG6_101790
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910