DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6kII and AKT3

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001357003.1	Gene:	AKT3 / 10000	HGNCID:	393	Length:	479	Species:	Homo sapiens

Alignment Length:	436	Identity:	146/436 - (33%)
Similarity:	224/436 - (51%)	Gaps:	81/436 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 TPTEDDESGGGNSGVTSSVTTVTSSQRRQQLQQVQQQSALQAALEQHHISPTADLDSARKRPTHR 131
            ||.|.:|       .|.::..|....:||:             .|:.:.|||:.:|:
Human    91 TPEEREE-------WTEAIQAVADRLQRQE-------------EERMNCSPTSQIDN-------- 127

  Fly   132 TLCPPPELMELSDSESQGGVETGGRREGATGRSAPDLEDTEPLYETENEFELKEVIKEGHDKADP 196
                                         .|....|...|.                  |.:...
Human   128 -----------------------------IGEEEMDASTTH------------------HKRKTM 145

  Fly   197 SQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRST-NERKILADVGHAF 260
            :.|:.|::||:|:||||.|||:   |.:|..||||:|||..:..||.|..| .|.::|.:..|.|
Human   146 NDFDYLKLLGKGTFGKVILVRE---KASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF 207

  Fly   261 IVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDL 325
            :..|.|:|||..:|..:::::.||:||..||:|.:|:|:..:||.||:..|:::||:..|:||||
Human   208 LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDL 272

  Fly   326 KPENILLDEHGHIALTDFGLSKQPL-DGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMY 389
            |.||::||:.|||.:|||||.|:.: |.:...:||||.||:|||::....:..|.|||..||:||
Human   273 KLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMY 337

  Fly   390 EMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAH 454
            ||:.|.|||:.|..::....||...:..|..||.:|:|||..|..::|..|||.|.....:|..|
Human   338 EMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRH 402

  Fly   455 CFFATIDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTSKSPRDSP 499
            .||:.::|..:..|::.|||.|.| |..|..|||.|:|:::...:|
Human   403 SFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITP 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	112/259 (43%)
		STKc_RSK_N	203..517	CDD:270734	127/300 (42%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
AKT3	NP_001357003.1	PH_PKB	4..110	CDD:269947	6/25 (24%)
		STKc_PKB_gamma	132..479	CDD:270745	132/338 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..479
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940