Protein Alignment l(1)G0196 and VIP1

DIOPT Version :9

• Sequence 1: NP_001097041.2
• Gene: l(1)G0196 / 33137
• FlyBaseID: FBgn0027279
• Length: 1846
• Species: Drosophila melanogaster
• Sequence 2: NP_013514.1
• Gene: VIP1 / 851126
• SGDID: S000004402
• Length: 1146
• Species: Saccharomyces cerevisiae
• Alignment Length: 1237
• Identity: 355/1237 - (28%)
• Similarity: 521/1237 - (42%)
• Gaps: 357/1237 - (28%)

  Fly     1 MSYTELESGYQDISQQHQQQNPHQSQPQQRVGFYLGLQDGNGDTDFGDSNDGMDSDTSTSSSNSK 65
            :|.:.:.:...:|:...:..:||..|               |..|...:|.|.:|..::|:|:.|
Yeast   125 LSNSNIVNDADNINSISKTGSPHLPQ---------------GTMDAEQTNMGTNSVPTSSASSRK 174

  Fly    66 QVV------------VGICAMAKKTQSKPMKEILTRL---GEFEFIKLVTFEENVILREPVQNWP 115
            ...            :|:|||..|..||||:.||.||   ||||   .|.|.:.|||.|.::|||
Yeast   175 SSTSHPKPRLPKVGKIGVCAMDAKVLSKPMRHILNRLIEHGEFE---TVIFGDKVILDERIENWP 236

  Fly   116 TCDCLVSFHSKGFPLEKAIEYAQLRNPFVLNNLHMQYDIQDRRRVYAILEKEGIEIPRYAVLDRD 180
            |||.|:||.|.||||:|||:|.:||.||::|:|.||..:.|||....:||...:..|....:.||
Yeast   237 TCDFLISFFSSGFPLDKAIKYVKLRKPFIINDLIMQKILWDRRLCLQVLEAYNVPTPPRLEISRD 301

  Fly   181 SPDPKHHEL--------------------IESEDHVEVNGITFNKPFVEKPVSAEDHNIYIYYPT 225
            .....:.||                    :..:|.:||:|.|..||||||||..|||||||||.:
Yeast   302 GGPRANEELRAKLREHGVEVKPVEEPEWKMVDDDTLEVDGKTMTKPFVEKPVDGEDHNIYIYYHS 366

  Fly   226 SAGGGSQRLFRKIGSRSSVYSPE-SRVRKTGSFIYEDFMPTDG-TDVKVYTVGPDYAHAEARKSP 288
            ..|||.:|||||:|::||.:.|. ...|..||:|||.||.||. .|||.||:|.::.|||.||||
Yeast   367 KNGGGGRRLFRKVGNKSSEFDPTLVHPRTEGSYIYEQFMDTDNFEDVKAYTIGENFCHAETRKSP 431

  Fly   289 ALDGKVERDSEGKEIRYPVILNHSEKLISRKVCLAFKQTVCGFDLLRANGKSYVCDVNGFSFVKN 353
            .:||.|.|::.|||:||...|:..||.|:.||..||.|.:|||||||.:|||||.|||||||||:
Yeast   432 VVDGIVRRNTHGKEVRYITELSDEEKTIAGKVSKAFSQMICGFDLLRVSGKSYVIDVNGFSFVKD 496

  Fly   354 SNKYYDDCAKILGNMILRELTPTLHIPWSVPFQLDDPPIVPTTFGKMMELRCVVAVIRHGDRTPK 418
            :..|||.||.||.:..:....       .:..:..:.||:.....:....:.:..:|||.|||||
Yeast   497 NKAYYDSCANILRSTFIEAKK-------KMDMEKKNLPIIREEKEQKWVFKGLAIIIRHADRTPK 554

  Fly   419 QKMKVEVRHPKFFEIFEKYDGYKLGHVKLKRPKQLQEILDIARFLLSEIHTKAHAEIEEKESKLE 483
            ||.|.....|.|..:.:   |:| ..|.::....|:.:|...|..|.|   ||     ...:|::
Yeast   555 QKFKHSFTSPIFISLLK---GHK-EEVVIRNVNDLKIVLQALRIALDE---KA-----GNPAKIK 607

  Fly   484 QLKNVLEMYGHFSGINRKVQMKYQPKGRPRGSSSDDTNLAADQPVEPSLVLILKWGGELTPAGRI 548
            .|.|.||...:|.|  .|:|:|              ..|..:..|| .:..|||||||.|.:.:.
Yeast   608 VLANALEKKLNFPG--TKIQLK--------------PVLNKENEVE-KVQFILKWGGEPTHSAKY 655

  Fly   549 QAEELGRIFRCMYPGGQGRSDYSGTQGLGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLAL 613
            ||.|||.         |.|.|:.        .|:.:...::||::|.|.||..||..:.:.|...
Yeast   656 QATELGE---------QMRQDFD--------LLNKSILQNIKIFSSSERRVLHTAQYWTRALFGA 703

  Fly   614 EGELTPILVQMVKSANTNGLLDNDCDSSKYQNLAKGRLHELMQNDREFSKE---DRELINPCNSK 675
            : ||....:.:.|.     |||:...:....:..|.:|..|::..:|...:   ..::..|
Yeast   704 D-ELGSDEISIRKD-----LLDDSNAAKDLMDKVKKKLKPLLREGKEAPPQFAWPSKMPEP---- 758

  Fly   676 SITQALDFVKNPVDCCHHVHLLIRELLHIISIKK---DDPKTKDAILYHGETW------DLMRCR 731
                               :|:|:.::.:::..|   |:...|..:......|      .|.:.|
Yeast   759 -------------------YLVIKRVVELMNYHKKIMDNNFAKKDVNSMQTRWCTSEDPSLFKER 804

  Fly   732 WEKIEKDFSTKSKLFDISKIPDIYDCIKYDLQHNQ----------------------HTL----- 769
            |:|:.|:|:...|: |.|||.::||.:|||..||:                      |:|
Yeast   805 WDKLFKEFNNAEKV-DPSKISELYDTMKYDALHNRQFLENIFDPGLPNEAIADELGSHSLVDRYP 868

  Fly   770 --------------------------------------------------QYD-----QAEELYI 779
                                                              |:|     |..|||.
Yeast   869 INVLAKNNFKIIDSHSMNNSGKNSSNSVGSLGWVLESGKTSTARNPKSSSQFDEPRFMQLRELYK 933

  Fly   780 YAKNLADIVIPQEYGLTPQEKLAIGQGICSPLLRKIKGDLQRNIDEVEDEFMNRLNPHYSHGVAS 844
            .||.|.|.:.|:|||::..|||.||.....||.::|..|:        .:..||..|..   ||
Yeast   934 LAKVLFDFICPKEYGISDAEKLDIGLLTSLPLAKQILNDI--------GDMKNRETPAC---VA- 986

  Fly   845 PQRHVRTRLYFTSESHVHSLLTVLRYGGLLNVVTDEQWRRAMDYISMVSELNYMSQIVIMLYEDP 909
                     |||.|||:::||.::...|:...:.    |.|:      .||:|:|||...|||
Yeast   987 ---------YFTKESHIYTLLNIIYESGIPMRIA----RNAL------PELDYLSQITFELYE-- 1030

  Fly   910 TKDPTSEERFHVELHFSPGVNCCVQKNLPPGPGFRPHSHGDNACNVSLQSSDESNPARIEEENDS 974
            :.|.:.::...:.|..|||   |               |..:..:|.|.
Yeast  1031 STDASGQKSHSIRLKMSPG---C---------------HTQDPLDVQLD---------------- 1061

  Fly   975 NSGEEREGKKRGTSGQRSTDRSAERISPAFGFNRLELRSKQFKSKPIPIGAHHTVSGHEAMDLAK 1039
                               ||                               |.:|....:.|.|
Yeast  1062 -------------------DR-------------------------------HYISCIPKISLTK 1076

  Fly  1040 RLNEELASHQQQQNQQLRPISP----DIRAVTPDCEPRSRSFEQRPTSGVCAKEPVSSPDFGDNS 1100
            .|:.:.. .|:.:|:..|.|.|    .:...:|:...:.|...::..|....|.|.||   |.:|
Yeast  1077 HLDMDYV-QQKLRNKFTRVIMPPKFTPVNITSPNLSFQKRKTRRKSVSVEKLKRPASS---GSSS 1137

  Fly  1101 RT 1102
            .|
Yeast  1138 ST 1139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0196	NP_001097041.2	His_Phos_2	402..926	CDD:278743	149/617 (24%)
VIP1	NP_013514.1	PPIP5K2_N	189..277	CDD:407922	49/90 (54%)
		Rimk_N	<274..>324	CDD:424006	10/49 (20%)
		CPSase_L_D2	<395..489	CDD:418439	53/93 (57%)
		His_Phos_2	538..1047	CDD:395259	149/617 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344975
Domainoid	1	1.000	145	1.000	Domainoid score	I982
eggNOG	1	0.900	-	-		E1_KOG1057
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	442	1.000	Inparanoid score	I259
Isobase	1	0.950	-	0	Normalized mean entropy	S1654
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001610
OrthoInspector	1	1.000	-	-		oto99700
orthoMCL	1	0.900	-	-		OOG6_101402
Panther	1	1.100	-	-	LDO	PTHR12750
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1640
SonicParanoid	1	1.000	-	-		X1173
TreeFam	1	0.960	-	-
	14	13.730