DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0196 and asp1

DIOPT Version :9

Sequence 1:	NP_001097041.2	Gene:	l(1)G0196 / 33137	FlyBaseID:	FBgn0027279	Length:	1846	Species:	Drosophila melanogaster
Sequence 2:	NP_587877.1	Gene:	asp1 / 2539244	PomBaseID:	SPCC1672.06c	Length:	920	Species:	Schizosaccharomyces pombe

Alignment Length:	976	Identity:	333/976 - (34%)
Similarity:	479/976 - (49%)	Gaps:	203/976 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 MDSDTSTSSSN--------SKQVVVGICAMAKKTQSKPMKEILTRL---GEFEFIKLVTFEENVI 106
            :|:::||.:::        :|:.|||||||..|.:|||.:.||.|:   ||||   .:.|.:|:|
pombe    11 IDTESSTRTASPVSSIVTPTKRNVVGICAMDAKARSKPCRNILNRIIAEGEFE---AIVFGDNMI 72

  Fly   107 LREPVQNWPTCDCLVSFHSKGFPLEKAIEYAQLRNPFVLNNLHMQYDIQDRRRVYAILEKEGIEI 171
            |.|.|:|||.||.|:.|:|.||||:||.:|.:||.||.:|::..|..:.|||.|..||:...:..
pombe    73 LDEAVENWPACDYLICFYSSGFPLKKAEKYVELRKPFCVNDVVFQELLWDRRLVLNILDAIRVST 137

  Fly   172 PRYAVLDRDSPDPKHHELIE----------------------SEDHVEVNGITFNKPFVEKPVSA 214
            |:..:..||. .||.::::|                      .||.:.|:|....||:|||||..
pombe   138 PQRLICSRDG-GPKINKVLEEKLRRKFGIEITEVPTPEVKMLDEDTLSVDGKIIKKPYVEKPVYG 201

  Fly   215 EDHNIYIYYPTSAGGGSQRLFRKIGSRSSVYSPESRVRKT-GSFIYEDFMPTDGT-DVKVYTVGP 277
            ||||||||:|.|.|||.::||||:.::||.|.|:....:| ||||||:||..|.. |||||||||
pombe   202 EDHNIYIYFPKSVGGGGRKLFRKVANKSSDYDPDLCAPRTEGSFIYEEFMNVDNAEDVKVYTVGP 266

  Fly   278 DYAHAEARKSPALDGKVERDSEGKEIRYPVILNHSEKLISRKVCLAFKQTVCGFDLLRANGKSYV 342
            .|:|||.||||.:||.|.|:..|||||:...|:..||.::.|:.:||:|.||||||||.:|:|||
pombe   267 HYSHAETRKSPVVDGIVRRNPHGKEIRFITNLSEEEKNMASKISIAFEQPVCGFDLLRVSGQSYV 331

  Fly   343 CDVNGFSFVKNSNKYYDDCAKILGNMI-LRELTPTLHIPWSVPFQLDDPPIVPTTFGKMMELRCV 406
            .||||:||||::|.|||:.|:||..|. :.|......:| ||...|:.||    ...:...|:.:
pombe   332 IDVNGWSFVKDNNDYYDNAARILKQMFHVAERHRRNRVP-SVQEVLNPPP----RESEAWRLKSL 391

  Fly   407 VAVIRHGDRTPKQKMKVEVRHPKFFEIFEKYDGYKLGHVK--LKRPKQLQEILDIARFLLSEIHT 469
            |.|:||.|||||||.|.......|.::.:       ||.:  :.|.:||..:| .|..|.:|:..
pombe   392 VGVLRHADRTPKQKFKFSFTSDPFVKLLQ-------GHTEEVILRNEQLNSVL-AATNLATELKC 448

  Fly   470 KAHAEIEEKESKLEQLKNVLEMYGHFSGINRKVQMK--YQPKGRPRGSSSDDTNLAADQPVEPSL 532
                   |..:||:||:..||......|  .|||:|  |.|:|:..                 .|
pombe   449 -------EDINKLKQLRLALETKKDLPG--TKVQLKPAYSPEGKLL-----------------KL 487

  Fly   533 VLILKWGGELTPAGRIQAEELGRIFRCMYPGGQGRSDYSGTQGLGLLRLHSTFRHDLKIYASDEG 597
            .||:|||||.|.:.|.|:::||..|.                 ..|..::.....|::||.|.|.
pombe   488 QLIIKWGGEFTHSARYQSKDLGEQFH-----------------KDLYIMNRDCLKDVEIYTSSER 535

  Fly   598 RVQMTAAAFAKGLLALEGELTPILVQMVKSANTNGLLDNDCDSSKYQNLAKGRLHELMQNDREFS 662
            ||..:|..||  :..||.|..|..:..|:    ..|||:...:....:..|..|..|::......
pombe   536 RVSASAEIFA--MAFLEQETIPSDLLKVR----KDLLDDSNAAKDTMDKVKKHLKSLLRVGDTAR 594

  Fly   663 KE---DRELINPCNSKSITQALDFVKNPVDCCHHVHLLIRELLHIISIKKDDPKTKDAILYHGET 724
            ||   ...:..||  :.:.|.:..:|      :| ..::||...|:..:.:..:::...   .|.
pombe   595 KEFTWPENMPKPC--EVMQQVVQLMK------YH-RAVMRENFIILGPEVEQVQSRWCC---NEN 647

  Fly   725 WDLMRCRWEKIEKDFSTKSKLFDISKIPDIYDCIKYDLQHNQHTL-------QY----------- 771
            ..|.|.||||:..:|....|. |.||:.::||.:|||..||:..|       ||
pombe   648 PALFRERWEKLFSEFCDSEKA-DPSKVSELYDTLKYDALHNRQFLERIFTPYQYLKLPQSPSLIA 711

  Fly   772 ----------------------------DQAEELYIYAKNLADIVIPQEYGLTPQEKLAIGQGIC 808
                                        ::..|||..||.|.|.|.|||||:.|:|||.||....
pombe   712 KEPPQRTDSNGNLVGMTGANTNHTERPLEKLYELYDLAKVLFDFVSPQEYGIEPKEKLEIGLLTS 776

  Fly   809 SPLLRKIKGDLQRNIDEVEDEFMNRLNPHYSHGVASPQRHVRTRLYFTSESHVHSLLTVLRYGGL 873
            .||||:|..|::.                     |....|..||:|||.|||:::||..:...||
pombe   777 VPLLRQIIHDIKE---------------------ARDSDHASTRMYFTKESHIYTLLNCILESGL 820

  Fly   874 LNVVTDEQWRRAMDYISMVSELNYMSQIVIMLYEDPTKDPTSEERFHVELHFSPG--VNCCVQKN 936
            ...:...|          :.||:|::||...|:|  ..:|:..:.|.|.:..|||  ..|.:..|
pombe   821 PMKLPRNQ----------IPELDYLTQICFELFE--RTNPSGNKEFSVRITLSPGCYAQCPLDMN 873

  Fly   937 L 937
            |
pombe   874 L 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0196	NP_001097041.2	His_Phos_2	402..926	CDD:278743	156/576 (27%)
asp1	NP_587877.1	ATP-grasp_4	<241..335	CDD:302634	56/93 (60%)
asp1	NP_587877.1	His_Phos_2	387..861	CDD:278743	156/576 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	138	1.000	Domainoid score	I1232
eggNOG	1	0.900	-	-		E1_KOG1057
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I322
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001610
OrthoInspector	1	1.000	-	-		oto101354
orthoMCL	1	0.900	-	-		OOG6_101402
Panther	1	1.100	-	-	LDO	PTHR12750
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1640
SonicParanoid	1	1.000	-	-		X1173
TreeFam	1	0.960	-	-
	12	11.850