Protein Alignment l(1)G0196 and F46F11.1

DIOPT Version :9

• Sequence 1: NP_001097041.2
• Gene: l(1)G0196 / 33137
• FlyBaseID: FBgn0027279
• Length: 1846
• Species: Drosophila melanogaster
• Sequence 2: NP_740855.2
• Gene: F46F11.1 / 172221
• WormBaseID: WBGene00018508
• Length: 1323
• Species: Caenorhabditis elegans
• Alignment Length: 1790
• Identity: 643/1790 - (35%)
• Similarity: 869/1790 - (48%)
• Gaps: 546/1790 - (30%)

  Fly    66 QVVVGICAMAKKTQSKPMKEILTRLGEF--EFIKLVTFEENVILREPVQNWPTCDCLVSFHSKGF 128
            ::.:|||||.:|..||||:.|:.::.:|  :::....|.|.||:.|||:|||.|.|||||||..|
 Worm    16 KITIGICAMNRKATSKPMRAIMKKIIDFYGQWVDSFIFPEQVIINEPVENWPLCHCLVSFHSTEF 80

  Fly   129 PLEKAIEYAQLRNPFVLNNLHMQYDIQDRRRVYAILEKEGIEIPRYAVLDRDSPDPKHHELIESE 193
            ||||||.|.:||||:|:|||..|||:.|||.|:.||...|||.||:..:.|..|:....||:|..
 Worm    81 PLEKAIAYVKLRNPYVINNLDRQYDLLDRRTVFKILSDNGIEHPRHGYVIRGRPNEPDTELVEHP 145

  Fly   194 DHVEVNGITFNKPFVEKPVSAEDHNIYIYYPTSAGGGSQRLFRKIGSRSSVYSPESRVRKTGSFI 258
            ||:||||..|||||||||:|:||||:|||||:|.|||||||||||.:|||.|||:|.|||.||:|
 Worm   146 DHIEVNGEVFNKPFVEKPISSEDHNVYIYYPSSVGGGSQRLFRKINNRSSWYSPKSEVRKEGSYI 210

  Fly   259 YEDFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVILNHSEKLISRKVCLA 323
            ||:|:|.||||||||.|||.||||||||:|.|||||||||:|||:||||||::.||.|::|:.||
 Worm   211 YEEFIPADGTDVKVYAVGPFYAHAEARKAPGLDGKVERDSDGKEVRYPVILSNKEKQIAKKIVLA 275

  Fly   324 FKQTVCGFDLLRANGKSYVCDVNGFSFVKNSNKYYDDCAKILGNMILRELTPTLHIPWSVPFQL- 387
            |.|||||||||||||||||||||||||||.|.|||:|.||||||.|:|....:.:  |.||..:
 Worm   276 FGQTVCGFDLLRANGKSYVCDVNGFSFVKTSTKYYEDTAKILGNQIVRHYAKSKN--WRVPSDMP 338

  Fly   388 ----------DDPPIVPTTFGKMMELRCVVAVIRHGDRTPKQKMKVEVRHPKFFEIFEKYDGYKL 442
                      ||||::.|..||:.|||||||||||||||||||||:.|...:||.:||||||||.
 Worm   339 QPPILDLGLGDDPPMITTPSGKLAELRCVVAVIRHGDRTPKQKMKLIVTDQRFFALFEKYDGYKK 403

  Fly   443 GHVKLKRPKQLQEILDIARFLL--------------------SEIHTKAH-AEI-EEKESKLEQL 485
            ..:|:|:|.||.|:|::||.|:                    .|||...| .|: ||:..|.||:
 Worm   404 HEIKMKKPNQLMEVLELARALVIEKQRDRHQILEKLREGTGEEEIHKSEHDLEVCEEEMKKWEQM 468

  Fly   486 KNVLEMYGHFSGINRKVQMKYQPKGRPRGSSSDDTNLAADQPVEPSLVLILKWGGELTPAGRIQA 550
            :.|||||||||||||||||||.   :.|.:.:.|..|..:   .|:|:||||||||||.||.:||
 Worm   469 RTVLEMYGHFSGINRKVQMKYL---KERETKTSDEELRRE---GPALLLILKWGGELTTAGNMQA 527

  Fly   551 EELGRIFRCMYPG---GQGRSDYSGTQGLGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLA 612
            |.|||:||.:|||   ..|:|....|||||.||||||:|||||||||||||||.|||||||||||
 Worm   528 EALGRLFRTLYPGIRRTDGKSSPEDTQGLGFLRLHSTYRHDLKIYASDEGRVQTTAAAFAKGLLA 592

  Fly   613 LEGELTPILVQMVKSANTNGLLDNDCDSSKYQNLAKGRLHELMQNDREFSKEDRELINPCNSKSI 677
            |||||||||:||||||||:||||:||.:..||...|..||:.:|.||:|:.:|...:||...::|
 Worm   593 LEGELTPILMQMVKSANTDGLLDDDCQARLYQTELKRYLHKALQADRDFTPQDYLELNPNGLRAI 657

  Fly   678 TQALDFVKNPVDCCHHVHLLIRELLHIISIKKDDPKTKDAILYHGETWDLMRCRWEKIEKDFSTK 742
            |.|::|:|||...||.:...:.::..:| ::....:...:.||..|:.||.:.||.|..::|..|
 Worm   658 TAAMEFIKNPRKMCHEIAGYVEKMCGVI-VEYSQTRPTGSTLYLQESMDLAQRRWNKELREFRRK 721

  Fly   743 SK----LFDISKIPDIYDCIKYDLQHNQHTLQYDQA--EELYIYAKNLADIVIPQEYGLTPQEKL 801
            :|    .|||||||||||.||||::||......::.  |.:|:..||:||||:|||||:..:.|:
 Worm   722 NKHGEVEFDISKIPDIYDNIKYDMEHNPDLCINNEVEFERMYVCVKNMADIVVPQEYGIKTENKM 786

  Fly   802 AIGQGICSPLLRKIKGDLQRNIDEVE-DEFMNRLNPHYSHGVASPQRHVRTRLYFTSESHVHSLL 865
            .|.|.:|:||||||:.||.|.::..| :|...||:|..|.|:|:|.||||||||||||||:|:|:
 Worm   787 VIAQRVCTPLLRKIRNDLHRCLENKESEETQTRLDPRASQGIATPFRHVRTRLYFTSESHIHTLM 851

  Fly   866 TVLRYGGLLNVVTDEQWRRAMDYISMVSELNYMSQIVIMLYEDPTKDPTSEE---RFHVELHFSP 927
            .::|||.|.: |.|::|:|||:::|.|:|.|||:|:|:|:|||..|:....:   |||:|:.|||
 Worm   852 NLIRYGNLCS-VDDKKWQRAMNFLSGVTEFNYMTQVVLMVYEDSRKENDEADTGPRFHIEILFSP 915

  Fly   928 GVNCCVQKNLPPGPGFRPHSHGDNACNVSLQSSDESNPARIEEENDSNSGEEREGKKRGTSGQRS 992
            |:..|.
 Worm   916 GLYPCF----------------------------------------------------------- 921

  Fly   993 TDRSAERISPAFGFNRLELRSKQFKSKPIPIGAHHTVSGHEAMDLAKRLNEELASHQQQQNQQLR 1057
                                                            |.|
 Worm   922 ------------------------------------------------LTE-------------- 924

  Fly  1058 PISPDIRAVTPDCEPRSRSFEQRPTSGVCAKEPVSSPDFGDNSRTRSSEFGETCHARVGTASNSD 1122
                           :.|.:|.|                          |..:.:.:..|:|.|.
 Worm   925 ---------------KERIYETR--------------------------FNLSTNPKPATSSRSS 948

  Fly  1123 GGGSHPRADHRTAFQIRVTNSLSFFKIDSSTNELPLSDIDFSLHPPTPQCGPLSHKRFHILTMRR 1187
            |..|            |.||       ||::
 Worm   949 GRES------------RDTN-------DSAS---------------------------------- 960

  Fly  1188 MESCDDGAELEQVRHLPQISPMATNERPLSSCNCSSSAAQAHSHSKSLMDLAQAVVMTSPQETGP 1252
              |..:|..       |.|..:.|                               |:|
 Worm   961 --SSTEGRR-------PSIEKVVT-------------------------------VVT------- 978

  Fly  1253 NSEQGCDPTTAADVSVSSFDDDFQLSSSAPAILMSAHFGNRPVVASLSSMVHVTTSPSASTLQLC 1317
                   ||..:..||:  :||..:||:|.:           ..|..:.:|:.||
 Worm   979 -------PTQLSTPSVT--NDDLSISSNAES-----------TAAESTGLVNTTT---------- 1013

  Fly  1318 RDKDKALASGTSSAHSKATSNSCGQLSMAGSAPVVTENPFRFTVSSL---GSAATNTACFVGSFE 1379
                            |..::|...|:...|..:|..:....|..::   |..|.......|:.:
 Worm  1014 ----------------KTHNDSEDDLNDVESVNLVALDELNNTTKAMADDGKTAKRQRSVTGAEK 1062

  Fly  1380 PIEEQITSIVEVDSKPLQPEPQVVYNLPTVLITGTA-SSSELSTKLNSNILPTVTNAFSAIDTEI 1443
            .:||..           :|..:...|       |.| |.|::|...|              :.|.
 Worm  1063 SMEEGD-----------KPHGEWKGN-------GVAKSGSQISVGSN--------------EMES 1095

  Fly  1444 NDEIGISKE-VGIGTIRITNTHTPCNKATVTRPDTKIAITTDPQTVTATETAEDTSMDIQPKICI 1507
            |:|   |.| ||.|                     |.....|....|....|.::..:::|.|.|
 Worm  1096 NNE---SMETVGGG---------------------KGQWVKDLLDQTKRAMAMNSIREVEPPIVI 1136

  Fly  1508 GKCAPGLLTPTVTTTDILKGIRDIAPTATQTSPPTFTPSTTTTTGAAAALFDNTATMSSNRPFTN 1572
                                             ||..|||||      |:.::.|:...:|
 Worm  1137 ---------------------------------PTPVPSTTT------AVVEDEASERQSR---- 1158

  Fly  1573 QFQSIDPTSNDAPHQHHVHQHQYQHHRKTTTTIINNTLNENHTTATITNNTTTTPSCCTKTIATD 1637
                          ......::::|                ||...:|..:........:.|:||
 Worm  1159 --------------SRRYFPYRFKH----------------HTAQLLTGMSGGGVHMQNRLISTD 1193

  Fly  1638 SQVSVSVSASVSSANASTSSRRQRHSIAGQMSYMKMLGFGGFSKKMATSANSLFSTAVISGSSSA 1702
                 .::......:...:||:.               ||        :..::.|||||:.||||
 Worm  1194 -----VLTGKFGDHDNKKNSRKD---------------FG--------AGTAVLSTAVIARSSSA 1230

  Fly  1703 PNLRDMITVSSSGF--GDV----PPIRPLETLHNALSLRKLDSFLQDMILAQIFKTPTGSPPRGF 1761
            |.|   :|..|..|  |::    ||:|.|||||::::|.:.|.||:.:|...:  ||..|||
 Worm  1231 PRL---MTYESEDFSVGEIKRFWPPLRSLETLHDSINLSQFDGFLERLIKGAL--TPLPSPP--- 1287

  Fly  1762 SKNTLPAVSSMTLTASNQTEVV-EHEPISTTVTPT 1795
             |..||  |:::..|.|:|... |.|.:...:.||
 Worm  1288 -KTPLP--SALSCDAINKTPTQDEVEKVIGKLAPT 1319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0196	NP_001097041.2	His_Phos_2	402..926	CDD:278743	289/558 (52%)
F46F11.1	NP_740855.2	ATP-grasp_4	<208..309	CDD:302634	79/100 (79%)
		His_Phos_2	363..914	CDD:278743	289/558 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163333
Domainoid	1	1.000	539	1.000	Domainoid score	I130
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49409
Inparanoid	1	1.050	1043	1.000	Inparanoid score	I135
Isobase	1	0.950	-	0	Normalized mean entropy	S1654
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001610
OrthoInspector	1	1.000	-	-		oto17324
orthoMCL	1	0.900	-	-		OOG6_101402
Panther	1	1.100	-	-	LDO	PTHR12750
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1640
SonicParanoid	1	1.000	-	-		X1173
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.870