DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cp110 and CCP110

DIOPT Version :10

Sequence 1:NP_788949.2 Gene:Cp110 / 33136 FlyBaseID:FBgn0031191 Length:666 Species:Drosophila melanogaster
Sequence 2:NP_001185951.2 Gene:CCP110 / 9738 HGNCID:24342 Length:1012 Species:Homo sapiens


Alignment Length:602 Identity:117/602 - (19%)
Similarity:222/602 - (36%) Gaps:149/602 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 QQTETLIYDSTRGQARPQTLVFGKQLPTIQVDPPTPQPFVKSIENTSPRRHNRITDRILQFEQSG 173
            |..:.:|.|:......|:.:   .:|||......:.:.:|.  :|||..:.:.:..:..|..||.
Human   406 QAMDLIIQDTDENTNVPEIM---PKLPTDLAGVCSSKVYVG--KNTSEVKEDVVLGKSNQVCQSS 465

  Fly   174 LGKLLPKVPDKCILRTSPAVAEDQQDQDTKDTTAR--ELGSPLA----------------EPANF 220
            ...|..||....:.......::::.......|.|.  :|..|.|                :||:.
Human   466 GNHLENKVTHGLVTVEGQLTSDERGAHIMNSTCAAMPKLHEPYASSQCIASPNFGTVSGLKPASM 530

  Fly   221 ---------QRSRSFTLEEPSQVLVEHMEREALAVKPSQSLAN--FEKQTIESQAKRVNRSARSI 274
                     :.::|:.::.||.:|:::.........|..|..|  |...:.|...:|::.....:
Human   531 LEKNCSLQTELNKSYDVKNPSPLLMQNQNTRQQMDTPMVSCGNEQFLDNSFEKVKRRLDLDIDGL 595

  Fly   275 SSKISHNSYNSNSSAATKSTIATKTTTAGSSCSRRD-------REVERIIERALDEHGALEASRK 332
            ..:.......|..:...:..:..|....||....::       :|.|.:::..:   .|.|..||
Human   596 QKENCPYVITSGITEQERQHLPEKRYPKGSGFVNKNKMLGTSSKESEELLKSKM---LAFEEMRK 657

  Fly   333 AGVRNYLRGHRERMNQLVIHQEKERRRMQAEFDHQQRQLIEEL-----CAEIDVSSATENPDSLI 392
                .....|.::::.|:..||:|:.|:|.|.:.|::.|.|:.     .:|:|:::|.|.....|
Human   658 ----RLEEQHAQQLSLLIAEQEREQERLQKEIEEQEKMLKEKKAMTAEASELDINNAVELEWRKI 718

  Fly   393 SQSTSTGDLQRFSPSPTLPSFSEDIEDFPTMEDKCQIAGPSSARKRLFSPKPSKDSEPQLLSAPS 457
            |.|:.                   :|...:..|....:..:|                       
Human   719 SDSSL-------------------LETMLSQADSLHTSNSNS----------------------- 741

  Fly   458 TPRSLPLRNSSLTNSRRSVQVVRRRSQS--VGGSLVKTITAADREVKKSPAKPGGGAGRPKSSPG 520
                     |..|||......|......  :.||....:|      |.|..:|.|          
Human   742 ---------SGFTNSAMQYSFVSANEAPFYLWGSSTSGLT------KLSVTRPFG---------- 781

  Fly   521 KNSSIIAKRGSAPPKSASPTKRLGNKYVELKQEERQWAATRINAGVRGFLVRRLFATEQVQRIVQ 585
                                 |...::.::...|.|....:|.|..:|||.|||..|::::::.|
Human   782 ---------------------RAKTRWSQVFSLEIQAKFNKITAVAKGFLTRRLMQTDKLKQLRQ 825

  Fly   586 TIRDTLIFVLNLHLET-CGHGLDAEEPANLRLKARLLQQLCSASRTLHLIFFQTNIKDRMEIIAR 649
            |::||:.|:.:...|. ...|:.:.:.|:  |:.|:|.||.:|...:|.|||..:..:||.|:..
Human   826 TVKDTMEFIRSFQSEAPLKRGIVSAQDAS--LQERVLAQLRAALYGIHDIFFVMDAAERMSILHH 888

  Fly   650 DRQRIKTKLLLKHRRLD 666
            ||:..|.|:|   |::|
Human   889 DREVRKEKML---RQMD 902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cp110NP_788949.2 CaM_bind 53..117 CDD:464981 2/7 (29%)
CCP110NP_001185951.2 CEP97 binding 1..223
CaM_bind 29..106 CDD:464981
Calmodulin-binding 64..82
Required for interaction with CEP290. /evidence=ECO:0000269|PubMed:18694559 67..82
Interaction with CEP76. /evidence=ECO:0000269|PubMed:19460342 350..565 28/163 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 611..633 3/21 (14%)
Stathmin <638..>704 CDD:459956 17/72 (24%)
EnvC <639..>808 CDD:443969 44/263 (17%)
Calmodulin-binding 781..821 13/70 (19%)
Calmodulin-binding 909..924
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 949..992
Blue background indicates that the domain is not in the aligned region.

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