DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp110 and si:ch73-100l22.3

DIOPT Version :9

Sequence 1:	NP_001033857.1	Gene:	Cp110 / 33136	FlyBaseID:	FBgn0031191	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_002663889.3	Gene:	si:ch73-100l22.3 / 100329274	ZFINID:	ZDB-GENE-141222-74	Length:	822	Species:	Danio rerio

Alignment Length:	796	Identity:	157/796 - (19%)
Similarity:	263/796 - (33%)	Gaps:	269/796 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SHSEATTPTATTTISIWSAPSEGSGSSSMDPVSFRFHLDGQPILPPLMTSAKKREVQLARQMAEA 83
            :..|..||..|:::.:                   ||  |..||||::...::.|::..|..|.:
Zfish    77 AEDEPHTPLTTSSLIV-------------------FH--GACILPPVLNEQQRVEMRTLRDTAVS 120

  Fly    84 L--EKRYRLARHSAGSDMASRRSVSQLQQTETLIYDSTRGQARPQTLVFGKQLPTIQVDPPTPQP 146
            |  .||.:.....:.|..|. .|:|..:| .|.|.||....:.|..|:             |..|
Zfish   121 LMTMKRRKRGEEESQSSFAD-VSISHAEQ-NTTITDSDIITSAPPALL-------------TCHP 170

  Fly   147 FVKSIENTSPRRHNRITDRILQFEQSGLGKLLPKVPDKCILRTSPAVAEDQQDQDTKDTTARELG 211
            .      ||....:|..::                     ||.||   |||....|:.|.
Zfish   171 L------TSTAHDDRSANQ---------------------LRASP---EDQSLDSTQITV----- 200

  Fly   212 SPLAEPANFQRSRSFTLEEPSQVLVEHMEREALAVKPSQSLANFEKQTIESQAKRVNRSARSISS 276
              |.|....:..||....:....::.    .......:..|:..|...:.||.
Zfish   201 --LFEGVGHKNDRSHDALDSQTAMMS----SGYVTNDNTDLSWMEAAAVRSQL------------ 247

  Fly   277 KISHNSYNSNSSAATKSTIATKTTTAGSSCSRRDREVERIIERALDEHGALEASRKAGVRNYLRG 341
                        .||.|.|.:.....|:.......||.. ::.|.|...|.|...:..::|.|:.
Zfish   248 ------------TATGSDIISHAPVDGAILEAEADEVSP-LKMADDLTDADEGPYRMSLQNLLKK 299

  Fly   342 HRE-RMNQLVIHQEKERRRMQAEFDHQQRQLIEELCAEI---DVSSATE---------NPDSLIS 393
            .:| |..|.::..:.:..:..|:......:..|||...|   ::..|.|         :.|....
Zfish   300 SQEYRRRQRLLRTQAKALKPSADEHSLSDKENEELPKHIWKTELRKAREKKKEKADLIHTDVFNQ 364

  Fly   394 QSTSTGDLQRFS------PSPTLPSFSEDIE----------------DFPTME-----DKCQIAG 431
            .:|.|.:.:..|      |.|..|.:...::                :.||.:     .:|:..|
Zfish   365 TNTHTANHEDISAVFTALPVPAKPLYGSRMKPLSVSRSHLAVDDKYANIPTPQFCSSPVRCKKGG 429

  Fly   432 PSSAR-KRLFSPKPSKDSEPQLLSAPSTPRSLPLRNSS---LTNSRRSVQVVRRRSQS------- 485
            .:||| ::..|....:......|........|.|..||   |.:...|...:....||
Zfish   430 GASARVQKALSRSDLRSVNDGGLMQTQQITQLELNLSSLKTLISDLESTLTLSHADQSDSPAHNC 494

  Fly   486 ------VGGSLVKTITAADREVKKSPAKPG---GGAGRPKSSPGKNSSIIAKRGS-----APP-- 534
                  .||::.:.:.|.|..::|..:..|   ..:.:...:.|:.||:|   ||     ||.
Zfish   495 VKRIVTFGGAVQQEVIAGDCGIEKQTSPVGVLTDNSNQRTHADGEGSSLI---GSSYDVDAPSSL 556

  Fly   535 -----------KSASPTKR--LGNKYVE-----------------LKQEERQW------------ 557
                       :..|..||  |.|:...                 |.:|||:.
Zfish   557 WSQLTPEVGGHEGVSRVKRRLLMNEETHCSPSTAVLQTQEDHVTFLMEEERRQQQELLQSLAVRY 621

  Fly   558 ------------AATRIN--------------------------AGVRGFLVRRLFATEQVQRIV 584
                        ||:|:.                          |.|:|||.|||..||:|..|:
Zfish   622 QFLRSVSFPCPSAASRLEDTPTSILASSVCTHTELTDAQVLCLAAVVKGFLTRRLLRTERVSHII 686

  Fly   585 QTIRDTLIFVLNLHLE-TCGHGLDAEEPANLRLKARLLQQLCSASRTLHLIFFQTNIKDRMEIIA 648
            :||:||.:|:.:.... :|.:        ::.|:.|:..||.||...||.:.|.::..::|::|.
Zfish   687 RTIKDTQMFLQSFQSSVSCRN--------DVMLQERVTLQLRSARLELHQLMFISSSCEQMQMIR 743

  Fly   649 RDRQRIKTKLLLKHRR 664
            :||:      |.:.||
Zfish   744 QDRE------LRRERR 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp110	NP_001033857.1	CALM_bind	53..141	CDD:292644	24/89 (27%)
si:ch73-100l22.3	XP_002663889.3	CALM_bind	88..157	CDD:318281	22/91 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576442
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008395
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13594
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.030