DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp110 and ccp110

DIOPT Version :9

Sequence 1:	NP_001033857.1	Gene:	Cp110 / 33136	FlyBaseID:	FBgn0031191	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_012826311.2	Gene:	ccp110 / 100170501	XenbaseID:	XB-GENE-981330	Length:	962	Species:	Xenopus tropicalis

Alignment Length:	818	Identity:	151/818 - (18%)
Similarity:	291/818 - (35%)	Gaps:	226/818 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 TISIWSAPS--EGSGSSSMDPVSFRFHLDGQPILPPLMT----SAKKREVQLARQMAEALE---- 85
            ::.:...||  ..:.|.::|.:....:|:|..|||.:::    ||:...::..:.:...|:
Frog    87 SVQVKKGPSINAHTESEAVDQMPSNKNLNGFTILPNVISLPVLSAQHESMKFEKSLENVLQNCTS 151

  Fly    86 -----KRYRLARHSAGSDMASRRSVS-QLQQTETLIYDSTRGQARPQTLVFGKQLPTIQVDPPTP 144
                 :...:.::|    :..:||:| .:.|::.|  .|......||:     :..|.......|
Frog   152 ESNKVEAIPVKKNS----LPIKRSISPAVDQSKDL--SSEMSSTPPQS-----EWDTASSSREAP 205

  Fly   145 QPFVKSIEN-----------TSPRRH------------------------NRITDRI-------- 166
            .|:..|::|           ...|||                        |.:.::.
Frog   206 DPYKMSLQNLLKKSREYIEKEQSRRHLKNPSKGSVSESNSDKENDTIKISNSLKEKAKVLNRSRS 270

  Fly   167 ---LQFEQSGLGK---LLPKVPDKC-----------------ILRTSPAVAEDQQDQDTKDTTAR 208
               |..::..|.|   ||.....:|                 ::..|.:|.|.:.|::.|.::..
Frog   271 CSPLMIDKPMLNKSNTLLQAASSQCQSLHFKSLSTLSNVDLPLISGSSSVVESESDEELKGSSFA 335

  Fly   209 ELGS-------------PLAEPA---NFQRSRSFTLEEPSQVLVEHMEREALAVKPSQSLANF-- 255
            :..|             |..||:   ...|.|...|...:.|:...:....|:.|.:.....|
Frog   336 DCESNILKSLTGSYAKLPSPEPSLSPKMHRRRPRPLSAGNIVITNPVNAYDLSPKENGKAMEFPL 400

  Fly   256 ----EKQTIES-------------QAKRVNRSARS-------------ISSKISHNSYNSNSSAA 290
                ||.::..             ..||.:.:.::             :::|....|.::|:...
Frog   401 PKTAEKTSLSDPVPKHGDYNAALLSIKRHSLNTQNAGFVPNIAGFPVCVATKFDSMSGSANAGTD 465

  Fly   291 TKSTIATKTTTAGSSCSRRDREVERIIERALD------EHG-----------------ALEASRK 332
            .:.|::|:.|.....||..:: |..::...:|      :||                 .:|.::.
Frog   466 IQHTVSTRGTQQMKLCSTFEK-VPCVLHHDIDLPDTMIQHGIKTNCLTCSPDMIKHSSPVELNKS 529

  Fly   333 AGVRNYLRGHRERMNQLVIHQEKERRR--------MQAEFDHQQRQLIEELCAEIDVSSATENPD 389
            ..|        |..:.::|..:...:.        ::..|...|..:..:...|:|:.  |..|.
Frog   530 YDV--------ETPSPILIQSQGSGQATETPLGPCLREPFLENQPDIQIKRRLELDLD--TTPPA 584

  Fly   390 S------LISQSTSTGDLQRFSPSPTLPS----FSEDIEDFPTMEDKCQ----------IAGPSS 434
            |      |..|...:|.||..|...:..|    |.:.:.||..|..|.:          ||....
Frog   585 SGEQKRWLHKQRNRSGSLQMTSTDLSKGSLGDHFKKKMLDFEEMRKKLEEQHAYQLSLLIAEQER 649

  Fly   435 ARKRLFSPKPSKDSEPQLLSAPSTPRSLPLRNSSLTNSRRSV---QVVRRRSQSVGG----SLVK 492
            .:::|  .:..::.|.||....:...:..|.:.|....|.::   .|..|.|..|..    |...
Frog   650 EQEKL--KREFEEEEKQLKLKDTESSTHTLDHGSRITDRNNITESSVQERVSFPVDNYHSCSTYS 712

  Fly   493 TITAADREVKKSPAKPGGGAGRPKSSPGKNSSIIAKRGSAPPKSASPTKRLGNKYVELKQEERQW 557
            |::|..:....|..:...|...|..|...::||.:..|           ||..::.::.....|.
Frog   713 TVSATSQHSYGSANESSLGLWGPVKSRAPSTSISSSHG-----------RLKTRWSQVYSPAMQR 766

  Fly   558 AATRINAGVRGFLVRRLFATEQVQRIVQTIRDTLIFVLNLHLE-TCGHGLDAEEPANLRLKARLL 621
            ...:..|..:|||.|||..||:::.:.:|::||..|:.....| ....|:.:.:.|:  |:.|:|
Frog   767 KFNKATALAKGFLTRRLMQTEKLKNLKKTVKDTAEFMRTFQSEFPLSRGMVSSQDAS--LQERVL 829

  Fly   622 QQLCSASRTLHLIFFQTNIKDRMEIIARDRQRIKTKLL 659
            .||.||...:|.|||.....:||.|:|.||:..:.|::
Frog   830 AQLRSALFEIHDIFFAMEPAERMNILAHDRELRREKMI 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp110	NP_001033857.1	CALM_bind	53..141	CDD:292644	18/101 (18%)
ccp110	XP_012826311.2	CALM_bind	32..104	CDD:406433	3/16 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008395
OrthoInspector	1	1.000	-	-		oto102791
Panther	1	1.100	-	-	LDO	PTHR13594
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5047
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.130