DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp2 and USP3

DIOPT Version :9

Sequence 1:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_006528.2	Gene:	USP3 / 9960	HGNCID:	12626	Length:	520	Species:	Homo sapiens

Alignment Length:	404	Identity:	138/404 - (34%)
Similarity:	189/404 - (46%)	Gaps:	84/404 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   594 SSALNSSSLKHNSDDGYKTASSSRDEKSEGLC--GLRNIGNTCFMNSVIQCLSHTQEL------- 649
            :|.|||..||.|   |..||          :|  ||||:|||||||:::|.||:.::.
Human   139 NSTLNSKLLKVN---GSTTA----------ICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKEL 190

  Fly   650 ---------TRFLRSHHGSRSLSTKDQQILHEFAKLIQEMWTANVHTVTPMELKRAFSTKHRMY- 704
                     |...|::| :||....:..::.||.|.:..:|..:         :.|||.:...|
Human   191 PAVELRNGKTAGRRTYH-TRSQGDNNVSLVEEFRKTLCALWQGS---------QTAFSPESLFYV 245

  Fly   705 --------SDYNQQDAQEFLRFFLDSLHSALNSGVKGET----LNIDDNLSDNKKADLTWEWYTR 757
                    ..|.||||.||:|:.||.||..|..|..|.:    |..:..||.:.|..:      .
Human   246 VWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSASNKCCI------N 304

  Fly   758 HENSLVRDLFVGQLKSTLKCTTCGNTSVTFDPFWDLSVPLPSSSR------------CKLEACLD 810
            ..:::|..:|.|.|::.:.|..||..|..||||.|||:.:||..|            |.|..||.
Human   305 GASTVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLR 369

  Fly   811 LFIREEVLDGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRFSETRW--SKLSNIVEFPTSD 873
            .|...|.||..|:..|.|||.::|.||.|.||:.||.|.:|||||..|.:  :|:...||||...
Human   370 SFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRG 434

  Fly   874 SELNMGSY---GANSN-SNVHYSLYAISNHMGSTAG-GHYVALCKHPVSRKWHEFNDNIVSDALS 933
              |:|..|   ..||. .:..|.|.|:..|.||..| |||.|...|  ..:|..|||:.|: ...
Human   435 --LDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATH--EGRWFHFNDSTVT-LTD 494

  Fly   934 ENHLVSSSAYILFY 947
            |..:|.:.||||||
Human   495 EETVVKAKAYILFY 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	126/372 (34%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	127/370 (34%)
USP3	NP_006528.2	zf-UBP	29..105	CDD:307999
USP3	NP_006528.2	UCH	159..508	CDD:306860	125/369 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950