DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp2 and USP10

DIOPT Version :9

Sequence 1:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_001259004.1	Gene:	USP10 / 9100	HGNCID:	12608	Length:	802	Species:	Homo sapiens

Alignment Length:	817	Identity:	178/817 - (21%)
Similarity:	298/817 - (36%)	Gaps:	232/817 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 EEQPQPSSSKSASHRYPRPKSTIIASAHSNFAASFEKFSGGLYRQTNGETNIESKTSSNARRYGI 345
            :|..:||.:      .||..|..|:|..:..|..|                |...|:|.....||
Human    66 DEVIEPSDT------LPRTPSYSISSTLNPQAPEF----------------ILGCTASKITPDGI 108

  Fly   346 DSLSIKASIEKFNNLSGQKRQNPGSGSGI-GPGSATA-----SGLGGGRLSVASRSNHGSQAGGS 404
            ...:...||:         .|.|||...: |..:..|     .|:.|| |....|.....:..|.
Human   109 TKEASYGSID---------CQYPGSALALDGSSNVEAEVLENDGVSGG-LGQRERKKKKKRPPGY 163

  Fly   405 SSNLQQRYSSDLDNIRVAAGYSSSLTRAAYRTTATMNSVSTPVAVTSELGGPISGDGGETATAMG 469
            .|.|:......:....:..|:::|         |..||||                 .|.|..||
Human   164 YSYLKDGGDDSISTEALVNGHANS---------AVPNSVS-----------------AEDAEFMG 202

  Fly   470 QPTSKVTVRGAHSNRQPIECDSVVLTNK-----ASKDATTAATP---TVATATATHTPATSSVST 526
            .....||.|..:|.:...:..|.::.:.     ...|..||..|   ..|....:..||.:...|
Human   203 DMPPSVTPRTCNSPQNSTDSVSDIVPDSPFPGALGSDTRTAGQPEGGPGADFGQSCFPAEAGRDT 267

  Fly   527 VTVTAAA-PNSASDSVSR-SLARSPISSTLARSGTGSSS------TARSV-LPPMTPTSSRYWDR 582
            ::.||.| |...:|:... .:|...|   |..||.|:::      |..|: |.|..|.|:.....
Human   268 LSRTAGAQPCVGTDTTENLGVANGQI---LESSGEGTATNGVELHTTESIDLDPTKPESASPPAD 329

  Fly   583 DSGTSRSSIGTSSALNSSSLKHNSDDGYKTASSS---------------------RDEKSEGLC- 625
            .:|::..::..|...:.:||.|:|    |.:|||                     :.|..|||.
Human   330 GTGSASGTLPVSQPKSWASLFHDS----KPSSSSPVAYVETKYSPPAISPLVSEKQVEVKEGLVP 390

  Fly   626 -----------------------------GLRNIGNTCFMNSVIQCL------------------ 643
                                         ||.|.||.|::|:.:|.|
Human   391 VSEDPVAIKIAELLENVTLIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKFIPLYSK 455

  Fly   644 -----SHTQELTRFLR--SHHGSRSLSTKDQQILHEFAKLIQEM---------WTANVHTVTPME 692
                 :.|..:..|:|  :...:..:..|.:|.|.:  |:::::         :...:.||.
Human   456 VQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGD--KIVRDIRPGAAFEPTYIYRLLTVN--- 515

  Fly   693 LKRAFSTKHRMYSDYNQQDAQEFLRFFLDSLHS----------------ALNSGVKGETLNIDDN 741
             |.:.|.|.|      |:||:|:|.|.|:.||.                .:::|.|..::|.::.
Human   516 -KSSLSEKGR------QEDAEEYLGFILNGLHEEMLNLKKLLSPSNEKLTISNGPKNHSVNEEEQ 573

  Fly   742 LSDNKKADLTWEWY-TRHENSLVRD----------LFVGQLKSTLKCTTCGNTSVTFDPFWDLSV 795
            ....:.::..||.. .|::.|:.|.          :|.|.::|.: .......|.|..||:.|.:
Human   574 EEQGEGSEDEWEQVGPRNKTSVTRQADFVQTPITGIFGGHIRSVV-YQQSSKESATLQPFFTLQL 637

  Fly   796 PLPSSSRCKLEACLDLFIREEVLDGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRFSETR- 859
            .:.|.....::..|:..:..|.:.|    ...|.|...:.::..|:::.|..||:|||||...:
Human   638 DIQSDKIRTVQDALESLVARESVQG----YTTKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKT 698

  Fly   860 --WSKLSNIVEFPTSDSELN--MGSYGA-NSNSNVH--YSLYAISNHMGSTA-GGHYVALCKHPV 916
              ..||...:|:|. |.|::  :.|.|. |.|...|  |.|:|:..|.|::| ||||........
Human   699 GGCQKLIKNIEYPV-DLEISKELLSPGVKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQIG 762

  Fly   917 SRKWHEFNDNIVSDALSENHLV----SSSAYILFYER 949
            ...|...:|..|. .:::..:|    ..:||:|:|.|
Human   763 LNGWLRIDDQTVK-VINQYQVVKPTAERTAYLLYYRR 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	91/426 (21%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	90/395 (23%)
USP10	NP_001259004.1	UCH	419..796	CDD:395355	90/395 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	75	1.000	Inparanoid score	I5268
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960