Protein Alignment Usp2 and USP2

DIOPT Version :10

• Sequence 1: NP_001285528.1
• Gene: Usp2 / 33132
• FlyBaseID: FBgn0031187
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_004196.4
• Gene: USP2 / 9099
• HGNCID: 12618
• Length: 605
• Species: Homo sapiens
• Alignment Length: 683
• Identity: 234/683 - (34%)
• Similarity: 320/683 - (46%)
• Gaps: 155/683 - (22%)

  Fly   334 SKTSSNARRYGIDSLSIKASIEKFNNLSGQKRQNPGSGSGIGPGSATASGLGGG-RLSVASRSNH 397
            |:.||..:||                 :...|......:..|.|:.|.|..|.. ..|:..:...
Human     2 SQLSSTLKRY-----------------TESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKL 49

  Fly   398 GSQAGGSSSNL--QQRY--SSDLDNIRVAAGYSSSLTRAAYRTTATMNSVSTPVAVTSELGGPIS 458
            |.:...:||.|  .:.|  ||.||..|........:|....|..:.......|      ||..:|
Human    50 GFKPVPTSSFLTRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERP------LGSGLS 108

  Fly   459 GDGGETATAMGQPTSKVTVRGAHSNRQPIEC--DSVVLTNKASKDATTAATPTVATATATHTPAT 521
            |..|..........|.:          ||..  ..|.||.|....:..|..             .
Human   109 GGSGFPYGVTNNCLSYL----------PINAYDQGVTLTQKLDSQSDLARD-------------F 150

  Fly   522 SSVSTVTVTAAAPNSASDSV---SRSLARSPISSTLARS-------------------------- 557
            ||:.|           |||.   .|:|.|||:   |||:
Human   151 SSLRT-----------SDSYRIDPRNLGRSPM---LARTRKELCTLQGLYQTASCPEYLVDYLEN 201

  Fly   558 --GTGSSSTARSVLPP------MTPT---SSRY--WD----RDSGTSRSSIGTSSALNSSSLKHN 605
              ..||:|...|..||      ::||   ..||  |:    :..|.||||......:||.|
Human   202 YGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETGKGQAPGPSRSSSPGRDGMNSKS---- 262

  Fly   606 SDDGYKTASSSRDEKSEGLCGLRNIGNTCFMNSVIQCLSHTQEL------TRFLRS-HHGSRSLS 663
                           ::||.||||:||||||||::||||:|:||      ..::|. ||||.:.:
Human   263 ---------------AQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHT 312

  Fly   664 TKDQQILHEFAKLIQEMWTANVH-TVTPMELKRAFSTKHRMYSDYNQQDAQEFLRFFLDSLHSAL 727
            .    ::.|||||||.:||::.: .|:|.|.|.........:..||||||||||||.||.||:.:
Human   313 A----LVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEV 373

  Fly   728 NSGV---KGETLNIDDNLSDNKKADLTWEWYTRHENSLVRDLFVGQLKSTLKCTTCGNTSVTFDP 789
            |...   |....|: |:|.|::|....|..|...|:|.:.|||||||||:|.||.||..|..|||
Human   374 NRVTLRPKSNPENL-DHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDP 437

  Fly   790 FWDLSVPLPSSS--RCKLEACLDLFIREEVLDGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHL 852
            |||||:|:....  ...|..|:.||.:|:||||||.|||.:|:.|::|.|.|:||||||.||:||
Human   438 FWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHL 502

  Fly   853 KRFSET--RWSKLSNIVEFPTSDSELNMGSYGANSNSNVHYSLYAISNHMGSTAGGHYVALCKHP 915
            |||||:  |.|||:..|.||..|  |::..:.:.:.::..|:|||:|||.|:|.||||.|.|:.|
Human   503 KRFSESRIRTSKLTTFVNFPLRD--LDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSP 565

  Fly   916 VSRKWHEFNDNIVSDALSENHLVSSSAYILFYE 948
            .:.:||.|||:.|: .:|.:.:.:|.||:||||
Human   566 GTGEWHTFNDSSVT-PMSSSQVRTSDAYLLFYE 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UBP12	<620..>800	CDD:227847	90/190 (47%)
		Peptidase_C19R	626..948	CDD:239139	159/336 (47%)
USP2	NP_004196.4	Necessary for interaction with MDM4. /evidence=ECO:0000269|PubMed:19838211	1..200		52/257 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	71..107		8/41 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	237..264		9/45 (20%)
		UCH	267..596	CDD:425685	158/336 (47%)
		Necessary for interaction with MDM4. /evidence=ECO:0000269|PubMed:19838211	403..503		55/99 (56%)