DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp2 and USP2

DIOPT Version :9

Sequence 1:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_004196.4	Gene:	USP2 / 9099	HGNCID:	12618	Length:	605	Species:	Homo sapiens

Alignment Length:	683	Identity:	234/683 - (34%)
Similarity:	320/683 - (46%)	Gaps:	155/683 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 SKTSSNARRYGIDSLSIKASIEKFNNLSGQKRQNPGSGSGIGPGSATASGLGGG-RLSVASRSNH 397
            |:.||..:||                 :...|......:..|.|:.|.|..|.. ..|:..:...
Human     2 SQLSSTLKRY-----------------TESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKL 49

  Fly   398 GSQAGGSSSNL--QQRY--SSDLDNIRVAAGYSSSLTRAAYRTTATMNSVSTPVAVTSELGGPIS 458
            |.:...:||.|  .:.|  ||.||..|........:|....|..:.......|      ||..:|
Human    50 GFKPVPTSSFLTRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERP------LGSGLS 108

  Fly   459 GDGGETATAMGQPTSKVTVRGAHSNRQPIEC--DSVVLTNKASKDATTAATPTVATATATHTPAT 521
            |..|..........|.:          ||..  ..|.||.|....:..|..             .
Human   109 GGSGFPYGVTNNCLSYL----------PINAYDQGVTLTQKLDSQSDLARD-------------F 150

  Fly   522 SSVSTVTVTAAAPNSASDSV---SRSLARSPISSTLARS-------------------------- 557
            ||:.|           |||.   .|:|.|||:   |||:
Human   151 SSLRT-----------SDSYRIDPRNLGRSPM---LARTRKELCTLQGLYQTASCPEYLVDYLEN 201

  Fly   558 --GTGSSSTARSVLPP------MTPT---SSRY--WD----RDSGTSRSSIGTSSALNSSSLKHN 605
              ..||:|...|..||      ::||   ..||  |:    :..|.||||......:||.|
Human   202 YGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETGKGQAPGPSRSSSPGRDGMNSKS---- 262

  Fly   606 SDDGYKTASSSRDEKSEGLCGLRNIGNTCFMNSVIQCLSHTQEL------TRFLRS-HHGSRSLS 663
                           ::||.||||:||||||||::||||:|:||      ..::|. ||||.:.:
Human   263 ---------------AQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHT 312

  Fly   664 TKDQQILHEFAKLIQEMWTANVH-TVTPMELKRAFSTKHRMYSDYNQQDAQEFLRFFLDSLHSAL 727
            .    ::.|||||||.:||::.: .|:|.|.|.........:..||||||||||||.||.||:.:
Human   313 A----LVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEV 373

  Fly   728 NSGV---KGETLNIDDNLSDNKKADLTWEWYTRHENSLVRDLFVGQLKSTLKCTTCGNTSVTFDP 789
            |...   |....|: |:|.|::|....|..|...|:|.:.|||||||||:|.||.||..|..|||
Human   374 NRVTLRPKSNPENL-DHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDP 437

  Fly   790 FWDLSVPLPSSS--RCKLEACLDLFIREEVLDGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHL 852
            |||||:|:....  ...|..|:.||.:|:||||||.|||.:|:.|::|.|.|:||||||.||:||
Human   438 FWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHL 502

  Fly   853 KRFSET--RWSKLSNIVEFPTSDSELNMGSYGANSNSNVHYSLYAISNHMGSTAGGHYVALCKHP 915
            |||||:  |.|||:..|.||..|  |::..:.:.:.::..|:|||:|||.|:|.||||.|.|:.|
Human   503 KRFSESRIRTSKLTTFVNFPLRD--LDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSP 565

  Fly   916 VSRKWHEFNDNIVSDALSENHLVSSSAYILFYE 948
            .:.:||.|||:.|: .:|.:.:.:|.||:||||
Human   566 GTGEWHTFNDSSVT-PMSSSQVRTSDAYLLFYE 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	159/337 (47%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	159/336 (47%)
USP2	NP_004196.4	Necessary for interaction with MDM4. /evidence=ECO:0000269\|PubMed:19838211	1..200		52/257 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..107		8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..264		9/45 (20%)
		UCH	266..596	CDD:278850	159/337 (47%)
		Peptidase_C19R	268..597	CDD:239139	159/336 (47%)
		Necessary for interaction with MDM4. /evidence=ECO:0000269\|PubMed:19838211	403..503		55/99 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	302	1.000	Domainoid score	I1398
eggNOG	1	0.900	-	-		E1_KOG1868
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	1	1.000	-	-		FOG0000821
OrthoInspector	1	1.000	-	-		otm41633
orthoMCL	1	0.900	-	-		OOG6_101021
Panther	1	1.100	-	-	LDO	PTHR21646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	1	1.000	-	-		X4948
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.810