Protein Alignment Usp2 and USP11

DIOPT Version :9

• Sequence 1: NP_001285528.1
• Gene: Usp2 / 33132
• FlyBaseID: FBgn0031187
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_001358001.1
• Gene: USP11 / 8237
• HGNCID: 12609
• Length: 920
• Species: Homo sapiens
• Alignment Length: 723
• Identity: 152/723 - (21%)
• Similarity: 222/723 - (30%)
• Gaps: 327/723 - (45%)

  Fly   551 SSTLARSGTGS------SSTARSVLPPMTPTSSRYWDRDSGTSRSSIGTS------SALNSSSL- 602
            |.|:..|.|.|      ::..|.::.|...|  |.|.::|..|...:..:      :||.:..|
Human   167 SHTVQFSHTDSIGLVLRTARERFLVEPQEDT--RLWAKNSEGSLDRLYDTHITVLDAALETGQLI 229

  Fly   603 ---KHNSDDGYKTAS--------SSRDEK---SEGLCGLRNIGNTCFMNSVIQCLSHTQELTRFL 653
               ....|..:.:|.        |..||.   ..|:|||.|:||||||||.:||||:..:||.:.
Human   230 IMETRKKDGTWPSAQLHVMNNNMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYF 294

  Fly   654 RSHHGSRSLSTKDQ-----QILHEFAKLIQEMWTANVHTVTPMELKRAFSTKHRMYSDYNQQDAQ 713
            .::.....|:.::.     :|...:|.|:::.|:.:..::.|...|.........:..|.|.|:|
Human   295 LNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQ 359

  Fly   714 EFLRFFLDSLHSALNSGVKGETLNIDD--NLSDNKKADLTWEWYTRHENSLVRDLFVGQLKSTLK 776
            |.|.|.||.||..||...|.|.:.:.|  ...|.:.|...|:.:.|..:|::.|.|.|..||||.
Human   360 ELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLV 424

  Fly   777 CTTCGNTSVTFDPFWDLSVPLPSS----------------------------------------- 800
            |..|||.|||||||..||||||.|
Human   425 CPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSKH 489

  Fly   801 ----------------------------------------------------------------- 800
                                                                             
Human   490 TGISPERMMVADVFSHRFYKLYQLEEPLSSILDRDDIFVYEVSGRIEAIEGSREDIVVPVYLRER 554

  Fly   801 ----------------------------------------------------------------- 800
                                                                             
Human   555 TPARDYNNSYYGLMLFGHPLLVSVPRDRFTWEGLYNVLMYRLSRYVTKPNSDDEDDGDEKEDDEE 619

  Fly   801 -----------------------------SRC--------------------------------- 803
                                         :||
Human   620 DKDDVPGPSTGGSLRDPEPEQAGPSSGVTNRCPFLLDNCLGTSQWPPRRRRKQLFTLQTVNSNGT 684

  Fly   804 ----------------------------------------------------KLEACLDLFIREE 816
                                                                :|:.|::||...|
Human   685 SDRTTSPEEVHAQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMKKAPVRLQECIELFTTVE 749

  Fly   817 VLDGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRFSETRWS--KLSNIVEFPTSDSELNMG 879
            .|:.:....|..||..:..||...:...|:.|:|||||||.|::|  ||..:||||..|.:.:..
Human   750 TLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEF 814

  Fly   880 SYGANSNSN---VHYSLYAISNHMGSTAGGHYVALCKHPVSRKWHEFNDNIVSDALSENHLVSSS 941
            .....:.||   ..|.|.|:|||.|....|||.....:..|.:||.|:||.|| .::||.:.|.:
Human   815 VIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSVS-PVNENQIESKA 878

  Fly   942 AYILFYER 949
            ||:|||:|
Human   879 AYVLFYQR 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	128/619 (21%)
		Peptidase_C19R	626..948	CDD:239139	128/618 (21%)
USP11	NP_001358001.1	UBP12	56..886	CDD:227847	151/721 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940