DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp2 and Usp21

DIOPT Version :9

Sequence 1:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	XP_038947029.1	Gene:	Usp21 / 688466	RGDID:	1588822	Length:	619	Species:	Rattus norvegicus

Alignment Length:	564	Identity:	185/564 - (32%)
Similarity:	259/564 - (45%)	Gaps:	99/564 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   446 PVAVTSELGGPISGDGG---ETATAMGQPTSKVTV----RGAHSN---RQPIECDSVVLTNKASK 500
            |.|.:.|...|:.|...   ......|.|..::..    ||..|.   |.|:..|..|
  Rat    85 PRARSKERRNPVPGPNSMLRPLPPRPGPPDERLKKLDLGRGRTSGSRPRGPLRADHGV------- 142

  Fly   501 DATTAATPTVATATATHTPATSSVSTVTVTAAAPNSASDSVSRSLARSPISSTLARSGTG--SSS 563
            ....:..||||....:.|..|.|.|.         |:.|.....:|..      ...|||  .::
  Rat   143 PLPGSPPPTVALPLPSRTNLTRSKSV---------SSGDLRPMGIALG------GHRGTGELGAA 192

  Fly   564 TARSVLPPMTPTSSRYWDRDSGTSRSSIG-------TSSALNSSSLKHNSDDGYKTASSS---RD 618
            .:|..|.|..||..|      .||...:|       ..|........|.|........|.   .|
  Rat   193 LSRLALRPEPPTLRR------STSLRRLGGFPGPPTLLSIRTEPPPSHGSFHMISARPSEPFYSD 251

  Fly   619 EK--------SEGLCGLRNIGNTCFMNSVIQCLSHTQELTRF-LRSHH------GSRSLSTKDQQ 668
            :|        ..|..||||:|||||:|:|:||||.|:.|..| ||...      |.|:     |:
  Rat   252 DKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRA-----QE 311

  Fly   669 ILHEFAKLIQEMW-TANVHTVTPMELKRAFSTKHRMYSDYNQQDAQEFLRFFLDSLHSALN---- 728
            :...||.:|..:| ..:...|.|...:..|......:|.|:||||||||:..::.||..:|
  Rat   312 LTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGR 376

  Fly   729 -------SGV------KGETLNIDDNLSDNKKADLTWEWYTRHENSLVRDLFVGQLKSTLKCTTC 780
                   ||.      :|..|:.:..|||:.:|:|.|:.|...|:|.:.|||||||||.|||..|
  Rat   377 RAPPILASGPVPSPPRRGGALHEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQAC 441

  Fly   781 GNTSVTFDPFWDLSVPLP----SSSRCKLEACLDLFIREEVLDGDEMPTCAKCKTRRKCTKSFTI 841
            |..|.||:.|.|||:|:|    :..:..|..|..||.:||.|:.:..|.|.:|:.:.:.||..|:
  Rat   442 GYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFSLFTKEEELESENAPVCDRCRQKTRSTKKLTV 506

  Fly   842 QRFPKYLVIHLKRFSETRWS-KLSNI-VEFPTSDSELNMGSYGANSNSNVHYSLYAISNHMGSTA 904
            ||||:.||:||.|||.:|.| |.|:: |:||.  ..|::|.:.::...:..|.|||:.||.||..
  Rat   507 QRFPRILVLHLNRFSTSRGSIKKSSVGVDFPL--QRLSLGDFASDKVGSPVYQLYALCNHSGSVH 569

  Fly   905 GGHYVALCKHPVSRKWHEFNDNIVSDALSENHLVSSSAYILFYE 948
            .|||.|||:  ....||.:||:.|| .:|||.:.||..|:|||:
  Rat   570 YGHYTALCR--CQTGWHVYNDSRVS-PVSENQVASSEGYVLFYQ 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	139/353 (39%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	140/352 (40%)
Usp21	XP_038947029.1	UCH	266..609	CDD:395355	139/352 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350801
Domainoid	1	1.000	302	1.000	Domainoid score	I1353
eggNOG	1	0.900	-	-		E1_KOG1868
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	1	1.000	-	-		FOG0000821
OrthoInspector	1	1.000	-	-		otm45757
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850