DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp2 and USP37

DIOPT Version :9

Sequence 1:NP_001285528.1 Gene:Usp2 / 33132 FlyBaseID:FBgn0031187 Length:950 Species:Drosophila melanogaster
Sequence 2:NP_065986.3 Gene:USP37 / 57695 HGNCID:20063 Length:979 Species:Homo sapiens


Alignment Length:741 Identity:162/741 - (21%)
Similarity:252/741 - (34%) Gaps:237/741 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   269 QLRHEQNQVQQQEEQPQPSSSKSASHRYPRPKSTIIASAHSNFAASFEKFSGGLYRQTNGETNIE 333
            ||.|....|..     :||.:|         :|.::.:...|...|.:|              :.
Human    52 QLSHNIKNVVL-----RPSGAK---------QSRLMLTLQDNSFLSIDK--------------VP 88

  Fly   334 SKTSSNARRYGIDSLSIKASIEKFNNLSGQKRQNPGSGS-GIGPGSATASGLGGGRLSVASRSNH 397
            ||.:...|.: :|::       ..|.|....:.:.|||| |...||.|:......:||.:.    
Human    89 SKDAEEMRLF-LDAV-------HQNRLPAAMKPSQGSGSFGAILGSRTSQKETSRQLSYSD---- 141

  Fly   398 GSQAGGSSSNLQQR----YSSDLDN-----IRVAAGYSSSLTRAAYRTTATMNSVSTP------- 446
             :||.....:|:.:    :...|.|     |:..||...:      ||..::.|.|||       
Human   142 -NQASAKRGSLETKDDIPFRKVLGNPGRGSIKTVAGSGIA------RTIPSLTSTSTPLRSGLLE 199

  Fly   447 ---------VAVTSELGG--PISGDGGETATAMGQPTSK---------VTVRGAHSNRQ----PI 487
                     ::..|||..  |...|......||..|:.|         ::::.:..||.    |:
Human   200 NRTEKRKRMISTGSELNEDYPKENDSSSNNKAMTDPSRKYLTSSREKQLSLKQSEENRTSGLLPL 264

  Fly   488 ECDSVVLTNKASKDATTAATPTVATATATHTPATSSVSTVTVTAAAPNSASDSVSRSLARSPISS 552
            :..|...:...||:.::..|....|..::.||                    |..|||       
Human   265 QSSSFYGSRAGSKEHSSGGTNLDRTNVSSQTP--------------------SAKRSL------- 302

  Fly   553 TLARSGTGSSSTARSVLPPMTPTSSRYWDRDSGTSRSSIGTSSALNSSSLKHNSD-DGY---KTA 613
                          ..||...|                      |:...|:.|.| .|:   :..
Human   303 --------------GFLPQPVP----------------------LSVKKLRCNQDYTGWNKPRVP 331

  Fly   614 SSSRDEKSEGLCGLRNIGNTCFMNSVIQCLSHTQELTRFLRSHHGSRSLSTKD---QQILHEFAK 675
            .||..::.  |.|..|:||||:||:::|.|...|.....|.    .:.:..|.   ..::..||.
Human   332 LSSHQQQQ--LQGFSNLGNTCYMNAILQSLFSLQSFANDLL----KQGIPWKKIPLNALIRRFAH 390

  Fly   676 LIQEMWTANVHTVTPM--ELKRAFSTKHRMYSDYNQQDAQEFLRFFLDSLH---SALNSGVKGET 735
            |:.:....|..|...:  ::|.|.|.....:|.|.|.||.|||...||.|.   ..||...|.|.
Human   391 LLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEP 455

  Fly   736 LNIDDNLSDNKKADLTWEWYTRHENSLVRDLFVGQLKSTLKCTTCGNTSVTFDPFWDLSV----- 795
            ::.::|..|...        ||.....|......:::.::.|..||......:.|.|||:     
Human   456 VSGEENSPDISA--------TRAYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLPRR 512

  Fly   796 --PLPSSSRCKLEACLDLFIREEVLDGDEMPTCAKCKTRRKCT-KSFTIQRFPKYLVIHLKRFSE 857
              |||..|   ::..||||.|.|.|:    .:|.||  ..||. ......|.|:.|::||||:| 
Human   513 KKPLPPRS---IQDSLDLFFRAEELE----YSCEKC--GGKCALVRHKFNRLPRVLILHLKRYS- 567

  Fly   858 TRWSKLSNIVEFPTSDSELNMGSYGANSNSNVHYSLYAISNHMGS--------TAGGHYVALCKH 914
                                         .||..||   :|.:|.        |...|.....|.
Human   568 -----------------------------FNVALSL---NNKIGQQVIIPRYLTLSSHCTENTKP 600

  Fly   915 PVSRKWHEFNDNIVSDALSENHLVSS 940
            |.:..|..  ...:|..|..:.:|:|
Human   601 PFTLGWSA--HMAISRPLKASQMVNS 624

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp2NP_001285528.1 UCH 624..947 CDD:278850 88/341 (26%)
Peptidase_C19R 626..948 CDD:239139 87/339 (26%)
USP37NP_065986.3 UCH_N 3..104 CDD:318809 15/87 (17%)
KEN box 1 32..34
D-box 1 71..79 0/7 (0%)
D-box 2 96..105 2/16 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..153 13/47 (28%)
D-box 3 160..168 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..304 27/161 (17%)
KEN box 2 221..223 0/1 (0%)
UCH 342..>601 CDD:306860 81/312 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..701
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 719..795
KEN box 3 782..784
Peptidase_C19 <881..949 CDD:239072
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1868
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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