DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp2 and USP29

DIOPT Version :9

Sequence 1:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_001376572.1	Gene:	USP29 / 57663	HGNCID:	18563	Length:	922	Species:	Homo sapiens

Alignment Length:	452	Identity:	109/452 - (24%)
Similarity:	166/452 - (36%)	Gaps:	115/452 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 NRQPIECDSVVLTNKASKDATTAAT--PTVATATATHTPA------TSSVSTVTVTAAAPNSASD 539
            ::.|......:|.|:..|...|.::  .|.........|.      |.|:..:......|:|..|
Human   151 SKSPTHVKKGILENQGGKGQNTLSSDVQTNEDILKEDNPVPNKKYKTDSLKYIQSNRKNPSSLED 215

  Fly   540 -SVSRSLARSPISSTLARSGTGSSSTARSVLPPMTPTSSRYWDRDSGTSRSSIGTSSALNSSSLK 603
             ...|.|...|..:|   :..|:.:...:||...|..:..             |.:|.|..   :
Human   216 LEKDRDLKLGPSFNT---NCNGNPNLDETVLATQTLNAKN-------------GLTSPLEP---E 261

  Fly   604 HN-SDDGYKTASSSRDEKSEGL-CGLRNIGNTCFMNSVIQCL----SHTQELTRFLRSHHGSRSL 662
            |: .|.....|....|..|:.| .|..|:||||:||:|:|.|    |...:|.
Human   262 HSQGDPRCNKAQVPLDSHSQQLQQGFPNLGNTCYMNAVLQSLFAIPSFADDLL------------ 314

  Fly   663 STKDQQILHEFAKLIQEMWTANVHTVTPM-----------------ELKRAFSTKHRMYSDYNQQ 710
               .|.:..|:..     :.|.:.|:|.:                 .:|:..|....::|...|.
Human   315 ---TQGVPWEYIP-----FEALIMTLTQLLALKDFCSTKIKRELLGNVKKVISAVAEIFSGNMQN 371

  Fly   711 DAQEFLRFFLDSLH---SALNSGVKGETLNIDDNLSDNKKADLTWEWYTRHENSLVRDLFV---- 768
            ||.|||...||.|.   ..||:     |||......|...:.      ..|..|....:||
Human   372 DAHEFLGQCLDQLKEDMEKLNA-----TLNTGKECGDENSSP------QMHVGSAATKVFVCPVV 425

  Fly   769 ----GQLKSTLKCTTCGNTSVTFDPFWDLSV-------PLPSSSRCKLEACLDLFIREEVLDGDE 822
                .:|:.:|.|..||:..:..:|...||:       |||.|    ::..||||.:||.|:.:
Human   426 ANFEFELQLSLICKACGHAVLKVEPNNYLSINLHQETKPLPLS----IQNSLDLFFKEEELEYN- 485

  Fly   823 MPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRFS-ETRWSKLSN--IVEFPTSDSELNMGSY 881
               |..|| ::.|....|..|..:.|:|||||:| ...|..:.|  .|..|.|   |::.||
Human   486 ---CQMCK-QKSCVARHTFSRLSRVLIIHLKRYSFNNAWLLVKNNEQVYIPKS---LSLSSY 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	81/301 (27%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	80/298 (27%)
USP29	NP_001376572.1	PH_USP37_like	4..106	CDD:270122
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..196		6/35 (17%)
		UCH	286..552	CDD:395355	80/298 (27%)
		Peptidase_C19	<823..883	CDD:239072
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1868
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810