DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp2 and usp8

DIOPT Version :9

Sequence 1:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	XP_009291628.1	Gene:	usp8 / 565434	ZFINID:	ZDB-GENE-030131-1949	Length:	1067	Species:	Danio rerio

Alignment Length:	847	Identity:	222/847 - (26%)
Similarity:	348/847 - (41%)	Gaps:	146/847 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 TSNGVLKYSVRSTTATATSTSTRNYGKL---KPLNNNQTTAGVAMMNGHTNNNN------NNTRN 211
            |||..:|...:.|.:|....:. .|..|   ||.:..:..|..|.|||......      .||..
Zfish   309 TSNAKVKPPRQQTPSTLPQLNF-TYPSLEEPKPASVCEEPASAAQMNGKPLEAEPPAEPATNTPP 372

  Fly   212 SSNINNGGNNNMQRQQQQHDDISFIDSDDPPATGG------PEAGISTTKTSICYFKPITPPLQL 270
            .::..|.....:.:....|         .||....      |.|..:||.|     .|:.||...
Zfish   373 LAHPTNTHTPPLAQPTTTH---------TPPLAPSATTHTPPLAPSATTHT-----PPLAPPAHT 423

  Fly   271 RHEQNQVQQQEEQPQPSSSKSASHRYPRPKSTIIASAHSNFAASFEKFSG-GLYRQTNGETNIES 334
            .............||...||..|...|.....|...|.|...|.....:| .:..::...|...|
Zfish   424 EAAAPPTASPRHTPQVDRSKKPSVIPPSSSKLISDPAVSEGPAPPAAHNGPSVPDRSVKPTTDPS 488

  Fly   335 KTSSNARRYGI--DSLSIKASIEKFNNLSGQKRQNPGSGSGIGPGSATASGLGGGRLSVASRSNH 397
            :..|..:|:.|  |:|.:   :||......|:|:                         |.....
Zfish   489 RALSAEQRWEIQKDTLDL---MEKAKREQEQRRR-------------------------AQEQEK 525

  Fly   398 GSQAGGSSSNLQQRYSSDLDNIRVAAGYSSSLTRAAYRTTATMNSVS--TPV----------AVT 450
            ..........|:::.:.:.|....:....|..|:......|.|.|:|  :|.          |.:
Zfish   526 LEDKQQDRRKLERQTAEEEDLKETSPEDKSRKTQKDTPADAPMKSMSLDSPAQFNTREPLTRAHS 590

  Fly   451 SELGGPISG--DGG----ETATAMGQPTSKVTVRGAHSNRQPIECDSVVLTNKA---SKDATTAA 506
            .|:|..:.|  ||.    :|.|.        |.|..||.           ||:.   ..:.:|..
Zfish   591 EEMGRTVPGLPDGWMKFLDTVTG--------TYRYYHSP-----------TNRVHLYPPEVSTPQ 636

  Fly   507 TPTVATATATHT-PATSSVSTVTVTAAAPNSASD--SVSRSLARSPISSTLARSGTGSSSTARSV 568
            ||      |.|| ||..:..|.|......:...:  .:.||.:...||..|      |:.|.:.
Zfish   637 TP------AKHTPPAQPAADTETEKQRQRDREREQSKLKRSYSSPDISQEL------SAETRQR- 688

  Fly   569 LPPMTPTSSRYWDRDSGTSRSSIGTSSALNSSSLKHNSDDGYKTASSSRDEKSEGLCGLRNIGNT 633
             |...|:.:|   .:...:.|:.........|:.|      .:..:.....:...|.||||:|||
Zfish   689 -PAAVPSINR---ENKPLAASTYAKVEITRPSAAK------IRNLNPVFGGQGPLLTGLRNLGNT 743

  Fly   634 CFMNSVIQCLSHTQELTRFLRSHHGSRSLSTKD-----QQILHEFAKLIQEMWTANVHTVTPMEL 693
            |:|||::|||.:|..:..:...::....::..:     .::..||:.:::.:|......::|::.
Zfish   744 CYMNSILQCLCNTVAMADYFNRNYYQDDINRANILGHKGEVAEEFSVVMKALWLGQYKMISPLDF 808

  Fly   694 KRAFSTKHRMYSDYNQQDAQEFLRFFLDSLHSALNS-----GVKGETLNIDDNLSDNKKADLTWE 753
            |......:..:|.|..||:||.|.|.:|.||..||.     |.|.|.:   ::|.|...|||.|.
Zfish   809 KGTICKINSRFSSYEHQDSQELLLFLMDGLHEDLNKADKRRGYKEEEI---EHLDDVSAADLAWS 870

  Fly   754 WYTRHENSLVRDLFVGQLKSTLKCTTCGNTSVTFDPFWDLSVPLPSSSRCKLEACLDLFIREEVL 818
            .:.:...|::..||.||.|||::|.:|.:.|.||:.|..|::.:.:||:|.|:.||.||.:||.|
Zfish   871 KHKQLNESIIVALFQGQFKSTVQCMSCQHKSRTFETFMYLTLEMTASSKCSLQDCLKLFHKEERL 935

  Fly   819 -DGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRFS-ETRW-SKLSNIVEFPTSDSELNMGS 880
             ||:.. .|..|||.|...|...|.:.|..|::|||||. |.|| .||..:|:||..:.:|:...
Zfish   936 TDGNRF-YCRHCKTHRDAIKRMQIWKLPPILLVHLKRFKYEGRWREKLQTLVDFPLDNLDLSQYV 999

  Fly   881 YGANSNSNVHYSLYAISNHMGSTAGGHYVALCKHPVSRKWHEFNDNIVSDALSENHLVSSSAYIL 945
            .|..:|.. .|:|||:|||.|...||||.|.||:|:.::|.:|:|:.||: :|.:.:.|.:|||.
Zfish  1000 IGPKNNLK-KYNLYAVSNHYGGMDGGHYTAYCKNPMKQRWFKFDDHEVSE-ISSSTVRSPAAYIF 1062

  Fly   946 FY 947
            ||
Zfish  1063 FY 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	122/335 (36%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	123/335 (37%)
usp8	XP_009291628.1	USP8_dimer	8..115	CDD:312504
		RHOD	175..306	CDD:320771
		Atrophin-1	<316..644	CDD:331285	77/395 (19%)
		UCH	735..1064	CDD:306860	121/334 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	1	1.000	-	-		FOG0000821
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101021
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850