DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp2 and usp2b

DIOPT Version :9

Sequence 1:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	XP_009300197.1	Gene:	usp2b / 564054	ZFINID:	ZDB-GENE-100208-2	Length:	518	Species:	Danio rerio

Alignment Length:	514	Identity:	199/514 - (38%)
Similarity:	280/514 - (54%)	Gaps:	79/514 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 ATPTVATATATHTPATS----SVSTVTVTAAAPNSA--SDSVSRSLARSPISSTLARS------- 557
            ::|..||.:...:|.:|    ..:...:....|..:  :.|.||.|:.||   .|||.
Zfish     6 SSPKYATGSTLLSPYSSYDPCDPTLAYIVRGQPQLSRYAPSTSRYLSPSP---CLARGVLFFPQE 67

  Fly   558 --------------GTGSSSTAR----SVLPPMTPTSSRYWDRDSGT-------SRSSIGTSS-- 595
                          |..|.|.:|    ..||.:.....|...|:..|       .|.|:..|.
Zfish    68 PERGRAALHSEPHVGRYSESYSRLQVKGQLPRINRPRGRSPSRNGYTCMSPLSRQRRSVSQSDLM 132

  Fly   596 -------------------ALNSSSLKHNSDDG---YKTASSSRDEKSEGLCGLRNIGNTCFMNS 638
                               |:..|:::..:|..   |.|:.:|::  ::||.||||:||||||||
Zfish   133 RELATLEICDQGAVERTVYAVKESAIRGRTDYSGPLYWTSENSKN--AQGLVGLRNLGNTCFMNS 195

  Fly   639 VIQCLSHTQELTRF-LRSHHGS--RSLSTKDQQILHEFAKLIQEMWT-ANVHTVTPMELKRAFST 699
            ::||||:|.:|..: ||:.|.:  .:.......::.|||||.|.:|| |:...::|.:.|.....
Zfish   196 ILQCLSNTHDLRDYCLRNTHRTDLNNNCRAKAALMDEFAKLTQTIWTSASNEAISPSDFKMQIQK 260

  Fly   700 KHRMYSDYNQQDAQEFLRFFLDSLHSALNS-GVKGETLNID-DNLSDNKKADLTWEWYTRHENSL 762
            ....:..||||||||||||.||.||:.:|. .||......| |:||:::|....|..|...|:|.
Zfish   261 YAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTVKSRAPVEDLDHLSEDEKGKRMWNKYLESEDSK 325

  Fly   763 VRDLFVGQLKSTLKCTTCGNTSVTFDPFWDLSVPL-PSSSRCKLEACLDLFIREEVLDGDEMPTC 826
            |.|||||||||:|.|:.||..|..||||||||:|: .:|....|..||.||.:|:||||:|.|||
Zfish   326 VVDLFVGQLKSSLTCSECGFCSTVFDPFWDLSLPIAKTSGEVSLNDCLRLFTKEDVLDGNERPTC 390

  Fly   827 AKCKTRRKCTKSFTIQRFPKYLVIHLKRFSE--TRWSKLSNIVEFPTSDSELNMGSYGANSNSNV 889
            .:|||||||||.||||:|||.||:|||||||  .|.||||..|.||.  .||::..:.::::.|.
Zfish   391 HRCKTRRKCTKKFTIQKFPKILVLHLKRFSECRVRTSKLSTFVNFPL--KELDLREFASDNSVNA 453

  Fly   890 HYSLYAISNHMGSTAGGHYVALCKHPVSRKWHEFNDNIVSDALSENHLVSSSAYILFYE 948
            .|:|||:|||.|::.||||.|.|:.|.:.:|:.:||:.|| .:|.:.:.||.||:||||
Zfish   454 VYNLYAVSNHTGTSLGGHYTAYCRSPCTGEWYTYNDSRVS-PMSSSQVCSSDAYVLFYE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	162/331 (49%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	162/330 (49%)
usp2b	XP_009300197.1	UCH	181..510	CDD:278850	162/331 (49%)
usp2b	XP_009300197.1	Peptidase_C19R	183..511	CDD:239139	162/330 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592537
Domainoid	1	1.000	306	1.000	Domainoid score	I1332
eggNOG	1	0.900	-	-		E1_KOG1868
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134008
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	1	1.000	-	-		FOG0000821
OrthoInspector	1	1.000	-	-		otm25084
orthoMCL	1	0.900	-	-		OOG6_101021
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4948
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.710