DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp2 and Usp37

DIOPT Version :9

Sequence 1:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_795946.2	Gene:	Usp37 / 319651	MGIID:	2442483	Length:	979	Species:	Mus musculus

Alignment Length:	664	Identity:	152/664 - (22%)
Similarity:	228/664 - (34%)	Gaps:	202/664 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 QTNGETNIESKTSSNAR--RYGIDSLSIKASIEKFNNLSGQKRQNPGSGS-GIGPGSATASGLGG 386
            |.|...:|:...|.:|.  |..:|::       ..|.|....:.:.|||| |...||.|:.....
Mouse    77 QDNSFLSIDKVPSKDAEEMRLFLDAV-------HQNRLHAAMKASQGSGSFGTILGSRTSQKETN 134

  Fly   387 GRLSVASRSNHGSQAGGSSSNLQQR---------YSSDLDNIRVAAGYSSSLTRAAYRTTATMNS 442
            .:||.:.     :||.....:|:.:         .|.....|:...|...::|    ||..::..
Mouse   135 RQLSYSD-----NQASSKRGSLETKDEIPFRKVLGSPGRGPIKTVTGGGMAVT----RTIPSLTL 190

  Fly   443 VSTP---------------VAVTSEL--GGPISGDGGETATAMGQPTSK---------VTVRGAH 481
            .|||               :...|||  ..|...|......||..|:.|         ::::.|.
Mouse   191 TSTPLRSGLLENRTEKRKRMLSGSELTEDYPKENDSSSNNKAMTDPSRKYLTSCREKQLSLKQAE 255

  Fly   482 SNRQ----PIECDSVVLTNKASKDATTAATPTVATATATHTPATSSVSTVTVTAAAPNSASDSVS 542
            .||.    |::..|...:...|||.::..|
Mouse   256 ENRTSGLLPLQSSSFYGSRAGSKDYSSGVT----------------------------------- 285

  Fly   543 RSLARSPISSTLARSGTGSSSTARSVLPPMTPTSSRYWDRDSGTSRSSIGTSSALNSSSLKHNSD 607
             :|.|..:||.     |.|:..:...||..||                      |:...|:.|.|
Mouse   286 -NLDRCNVSSQ-----TPSAKRSLGFLPQPTP----------------------LSVKKLRCNQD 322

  Fly   608 -DGYKTASSSRDEKSEGLCGLRNIGNTCFMNSVIQCLSHTQELTRFLRSHHGSRSLSTKD---QQ 668
             .|:...........:.|.|..|:||||:||:::|.|...|.....|.    .:|:..|.   ..
Mouse   323 YAGWNRPRVPLSSHQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLL----KQSIPWKKIPFNA 383

  Fly   669 ILHEFAKLIQEMWTANVHTVTPM--ELKRAFSTKHRMYSDYNQQDAQEFLRFFLDSLH---SALN 728
            ::..||.|:.:....|..|...:  ::|.|.|.....:|.|.|.||.|||...||.|.   ..||
Mouse   384 LIRRFANLLIKKDICNSETKKELLKKVKNAISATAERFSGYVQNDAHEFLSQCLDQLKEDMEKLN 448

  Fly   729 SGVKGETLNIDDNLSDNKKADL-TWEWYTRHENSLVRDLFVGQLKSTLKCTTCGNTSVTFDPFWD 792
            ...|.|.:..::||.|.....: |....|..|         .:::.::.|..||.|....:.|.|
Mouse   449 KTWKTEPVLGEENLPDTSATKVFTCPVITNLE---------FEVQHSIICKACGETIPKREQFND 504

  Fly   793 LSV-------PLPSSSRCKLEACLDLFIREEVLDGDEMPTCAKCKTRRKCT-KSFTIQRFPKYLV 849
            ||:       |||..|   ::..||||.|.|.|:    .:|.||  ..||. ......|.|:.|:
Mouse   505 LSIDLPRRKKPLPPRS---IQDSLDLFFRAEELE----YSCEKC--GGKCALVRHKFNRLPRVLI 560

  Fly   850 IHLKRFSETRWSKLSNIVEFPTSDSELNMGSYGANSNSNVHYSLYAISNHMGS--------TAGG 906
            :||||:|                              .||..||   :|.:|.        |...
Mouse   561 LHLKRYS------------------------------FNVALSL---NNKLGQQVIIPRFLTLAS 592

  Fly   907 HYVALCKHPVSRKW 920
            |.....|.||:..|
Mouse   593 HCTESTKPPVTLGW 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	88/322 (27%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	87/320 (27%)
Usp37	NP_795946.2	UCH_N	3..105	CDD:406959	7/34 (21%)
		KEN box 1. /evidence=ECO:0000250	32..34
		D-box 1. /evidence=ECO:0000250	71..79		1/1 (100%)
		D-box 2. /evidence=ECO:0000250	96..105		2/15 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..178		16/66 (24%)
		D-box 3. /evidence=ECO:0000250	160..168		1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	192..240		11/47 (23%)
		KEN box 2. /evidence=ECO:0000250	222..224		0/1 (0%)
		UCH	342..>601	CDD:395355	84/313 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	719..795
		KEN box 3. /evidence=ECO:0000250	782..784
		Peptidase_C19	<886..949	CDD:239072
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1868
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900