DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp2 and Usp8

DIOPT Version :9

Sequence 1:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_001099972.1	Gene:	Usp8 / 296121	RGDID:	1304979	Length:	1081	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	168/570 - (29%)
Similarity:	253/570 - (44%)	Gaps:	119/570 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 DGGETATAMGQPT--------SKVTVRG-----AHSNRQPIECDSV------VLTNKASKDATTA 505
            ||.:.||...:.:        :||:|.|     :...::|.:..|.      :...||.::..|.
  Rat   537 DGAQDATGTQRQSKSEHDASDAKVSVEGKRCPMSEVQKRPADVSSASSMSGELSAGKAQREPLTR 601

  Fly   506 A--------------------TPTVATATATHTPATSSVSTVTVTAAAPNSASDSVSRSLARSPI 550
            |                    .|...|....|:|      |.||....|..|..||
  Rat   602 ARSEEMGRIVPGLPLGWAKFLDPITGTFRYYHSP------TNTVHMYPPEMAPSSV--------- 651

  Fly   551 SSTLARSGTGSSSTARSVLPPMTPTSSRY-----WDRDSGTSRSSIGTSS--------------- 595
                               ||.||.:.:.     .:||...|:.....||
  Rat   652 -------------------PPSTPPTHKVKPQIPAERDREPSKLKRSYSSPDITQALQEEEKRRP 697

  Fly   596 ALNSSSLKHNSDDGYKTASSSRDEKSE-------------GLCGLRNIGNTCFMNSVIQCLSHTQ 647
            |:..:..:.|....|..|..||...|:             .|.||||:||||:|||::|||.:..
  Rat   698 AVTPTVNRENKPPCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAP 762

  Fly   648 ELTRFLRSH------HGSRSLSTKDQQILHEFAKLIQEMWTANVHTVTPMELKRAFSTKHRMYSD 706
            .|..:...:      :.|..|..|. ::..||..:::.:||.....::|.:.|......:..::.
  Rat   763 HLADYFNRNCYQDDINRSNLLGHKG-EVAEEFGIIMKALWTGQYRYISPKDFKVTIGKINDQFAG 826

  Fly   707 YNQQDAQEFLRFFLDSLHSALN--SGVKGETLNIDDNLSDNKKADLTWEWYTRHENSLVRDLFVG 769
            .:|||:||.|.|.:|.||..||  ...|......:|:|.|.|.|:..|:.:.:...|::..||.|
  Rat   827 SSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQG 891

  Fly   770 QLKSTLKCTTCGNTSVTFDPFWDLSVPLPSSSRCKLEACLDLFIREEVLDGDEMPTCAKCKTRRK 834
            |.|||::|.||...|.||:.|..||:||.|:|:|.|:.||.||.:||.|..:....|:.|:.||.
  Rat   892 QFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRD 956

  Fly   835 CTKSFTIQRFPKYLVIHLKRFS-ETRW-SKLSNIVEFPTSDSELNMGSYGANSNSNVHYSLYAIS 897
            ..|...|.:.|..|::|||||| :.|| .||...|:||..:.:|:....|..| |...|:|:::|
  Rat   957 SLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKS-SLKKYNLFSVS 1020

  Fly   898 NHMGSTAGGHYVALCKHPVSRKWHEFNDNIVSDALSENHLVSSSAYILFY 947
            ||.|...||||.|.||:...::|.:|:|:.||| :|.:.:.||:||||||
  Rat  1021 NHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSD-ISVSSVRSSAAYILFY 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	125/332 (38%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	126/332 (38%)
Usp8	NP_001099972.1	USP8_dimer	6..115	CDD:401063
		Radial_spoke_3	<80..>160	CDD:399236
		Rhodanese	193..304	CDD:395463
		PTZ00121	<453..610	CDD:173412	14/72 (19%)
		UCH	740..1069	CDD:395355	124/331 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1868
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	1	1.000	-	-		FOG0000821
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101021
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720