DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp2 and ubp8

DIOPT Version :9

Sequence 1:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_592992.1	Gene:	ubp8 / 2542135	PomBaseID:	SPAC13A11.04c	Length:	449	Species:	Schizosaccharomyces pombe

Alignment Length:	353	Identity:	80/353 - (22%)
Similarity:	143/353 - (40%)	Gaps:	91/353 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   623 GLCGLRNIGNTCFMNSVIQCLSHTQELTR--FLRSHHGSRS------------------LSTKDQ 667
            ||.|::|:|.||||:.::|.:.| ..|.|  |....|.|..                  .::|::
pombe   143 GLRGIQNLGATCFMSVILQSILH-NPLVRNLFFSGFHTSTDCKRPTCMTCAIDDMFSSIYNSKNK 206

  Fly   668 QILHEFAKLIQEMWTANVHTVTPMELKRAFSTKHRMYSDYNQQDAQEFLRFFLDSLHSALNSGVK 732
            ...:....::..||..:                 :....|:|||..||..:.||.:|:....|
pombe   207 STFYGPTAVLNLMWKLS-----------------KSLCGYSQQDGHEFFVYLLDQMHTESGGG-- 252

  Fly   733 GETLNIDDNLSDNKKADLTWEWYTRHENSL-----VRDLFVGQLKSTLKCTTCGNTSVTFDPFWD 792
                                       .|:     :..:|.|.||:.:.|..|....|..||..|
pombe   253 ---------------------------TSMPCTCPIHRIFSGSLKNVVTCLDCKKERVAVDPLMD 290

  Fly   793 LSVPLPSSSRCKLEACLDLFIREEVLDGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRFSE 857
            :|:.:...:   |:.||:.|:.:|.:    ..:|..|.: :...|.....:.|..:.:.||||.:
pombe   291 ISLDINEPT---LQGCLERFVSKEKV----QYSCHSCGS-KNAIKQLVFDKLPPTICMQLKRFEQ 347

  Fly   858 TRW---SKLSNIVEFPTSDSELNMGSYGANSNSNVHYSLYAISNHMGSTAGGHYVALCKHPVSRK 919
            ..:   :|:...|.:|   :.|.| .|..|.: :|.|.||::..|.|:...|||:|...:  ..:
pombe   348 NNFAMSTKIDKQVSYP---AFLRM-RYNFNQD-DVDYQLYSVVCHKGTLDTGHYIAYTYY--QNQ 405

  Fly   920 WHEFNDNIVSDALSENHLVSSSAYILFY 947
            |...:|..:.: :.|:.:::|.||:|||
pombe   406 WFLLDDTTIVE-VKESEVLNSQAYLLFY 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	77/350 (22%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	78/350 (22%)
ubp8	NP_592992.1	ZnF_UBP	37..85	CDD:197632
		UCH	144..432	CDD:278850	77/350 (22%)
		Peptidase_C19D	145..433	CDD:239125	78/351 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940