DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp2 and cyk-3

DIOPT Version :9

Sequence 1:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_001022992.1	Gene:	cyk-3 / 175853	WormBaseID:	WBGene00000874	Length:	1178	Species:	Caenorhabditis elegans

Alignment Length:	1030	Identity:	199/1030 - (19%)
Similarity:	290/1030 - (28%)	Gaps:	455/1030 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 SSKSASHRY-----PRPKSTIIASAHSNFAASFEKFSGGLYRQTNG------------------- 328
            |.:..|:.|     |....|:..|  ||..::...|  |::.|.|.
Worm   232 SDEELSNMYKDLNVPEEHQTVTKS--SNGKSALVDF--GIWAQENEKYVNEYYSMALQIGHICLG 292

  Fly   329 --------ETNIESKTSSNARRYGIDSLSIKAS---IEKFNNLSGQKRQNPGSGSGIGPGSATAS 382
                    |..|.::....|....:...:|.||   .|..:.|...|..||...|||
Worm   293 LRPESRKMELQIVNEFEKRASELPLSEWNIVASGWHAELRSFLEADKNPNPIDNSGI-------- 349

  Fly   383 GLGGGRLSVASRSNHGSQAGGSSSNLQQRYSSDL---DNIRVAAGYSSSLTRAAYR---TTATMN 441
                    ..:|.:..:......|....|...||   |.|||..    .|.||..|   ...|::
Worm   350 --------KGTREDSWTSKVACISAESARLKPDLIPSDYIRVPV----PLWRAWLRWHGCALTVD 402

  Fly   442 SVSTPVAVTSELGGPISGDGGETATAMGQPTSKVTVRGAHSNRQPIECDSVVLTNKASKDATTAA 506
            |..|    ...|.|....|        .:|..::         .|:|...:....|.|:|.|
Worm   403 SQFT----RKYLDGEFFED--------NKPALEL---------YPLEILLLGHDRKKSQDGT--- 443

  Fly   507 TPTVATATATHTPATSSVSTVTVTAAAPNSASDSVSRSLARSPISSTLARSGTGSSSTARSVLPP 571
                     .:||     .::|..|.|..|.|.:|...||   :..|..|.|.|
Worm   444 ---------ENTP-----RSLTSWACAQVSRSMTVDELLA---LCKTELRLGDG----------- 480

  Fly   572 MTPTSSRYWD-----------RDSGTSR-----SSIGTSSALNS----------------SSLKH 604
                .:|.|.           .|.|...     ||:|.:..:|.                ..|:.
Worm   481 ----DARLWQVVKENEEGNVLLDDGAQNLHQLYSSLGKTKKVNKMKLLLEVRERGTGVWPEELRA 541

  Fly   605 NSDDGYKTASSSRDEKSE--------GLCGLRNIGNTCFMNSVIQCLSHTQELTRFLRSHHGSRS 661
            :......||:|:....::        |..||.|.||.|:.|:.||||:....||::........:
Worm   542 SLSGKQITAASTLSSNAQLSDSSGRPGAVGLVNYGNFCYRNAGIQCLARVSPLTQYFLDEDNLDA 606

  Fly   662 LSTKD------QQILHEFAKLIQEMWTANVHTVTPMELKRAFSTKHRMYSDYNQQDAQEFLRFFL 720
            :...:      .:...|:|||::|||.|....:.|.:...|......|:....|.|.|||:.|.|
Worm   607 IKRGNLRRGDAAETTIEYAKLLREMWAAKKKNIAPNDFNDAIRLSSDMFECSEQHDCQEFVAFLL 671

  Fly   721 DSLHSALNSGVKG------ETLNIDDN-LSDN-------------KKADLTWEWYTRHENSLVRD 765
            |.||:::....|.      |:...|.| |||:             :||:.:|..|.:...|||..
Worm   672 DQLHTSMYESNKSLHPSPEESEGTDSNKLSDSSKKKEADKEEADEEKAERSWTEYEKQNESLVTQ 736

  Fly   766 LFVGQLKSTLKCTTCGNTSVTFDPFWDLSVPL--------------------------------- 797
            ||.|||:|.|.|.||.::|..|:||..||:|:
Worm   737 LFTGQLRSRLICRTCQSSSSVFEPFTSLSLPIGFEDVDLYQVIVVHRDGRIPRRYGFRLSRDSKV 801

  Fly   798 --------------------------------------------------PSSSR---------- 802
                                                              ||.:|
Worm   802 GNLREVVAVSSGISMSHLTIQCMSSKGTLMSRSPNHRSSNLRDELPLSSFPSGARLYALELPEST 866

  Fly   803 ----------------------------------------------------------------- 802

Worm   867 GEDQWRVAMHRKLQYNHEPYILGSTAGFIVSRFGLPLIVGLDEEVTGKKLYEDVMYQMHRFMEHS 931

  Fly   803 -----------------------------------------CK---------------------- 804
                                                     |:
Worm   932 VNSSSSRAHDPCEDENSGYPFTLCLVDPNYEWCGQCPALRFCRGCPIRPDESKVFIPANCPIAVD 996

  Fly   805 ------------------------------------LEACLDLFIREEVLDGDEMPTCAKCKTRR 833
                                                ||.|::.|...|.||.  ...|.:|:.:.
Worm   997 WLPIALYLRYNHSQEQACEDDPSVAETWSRHFAPSSLEHCIEKFSCPETLDA--AIQCDRCEKKT 1059

  Fly   834 KCTKSFTIQRFPKYLVIHLKRF----SETRWSKLSNIVEFPTSDSELNMGSYGANSNSNVHYSLY 894
            ...|..||.:.||||:||||||    .:.|..|....|.||.  ...:...:....:.|. |...
Worm  1060 MRDKVMTIWKLPKYLIIHLKRFEFLREQGRMGKCKRTVNFPL--KHFDPAPFVDKPDGNT-YECI 1121

  Fly   895 AISNHMGSTAGGHYVALCKHPVSRKWHEFNDNIVSDALSENHLVSSSAYILFYER 949
            |::||.|..:.||::|..|.. ..||...||..|.: :||..:....||:|||||
Worm  1122 ALANHYGQLSCGHFIAYAKSN-EDKWLLLNDCSVRE-VSEEEVDKQGAYLLFYER 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	116/609 (19%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	117/608 (19%)
cyk-3	NP_001022992.1	EFh_PEF	23..201	CDD:330173
		EF-hand_7	177..241	CDD:316058	2/8 (25%)
		Peptidase_C19	322..1175	CDD:321984	184/936 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.040